1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Tripamide

Tripamide 

Cat. No.: HY-106570
Handling Instructions

Tripamide is an orally active sulfonamide-derived diuretic antihypertensive agent.

For research use only. We do not sell to patients.

Tripamide Chemical Structure

Tripamide Chemical Structure

CAS No. : 73803-48-2

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Description

Tripamide is an orally active sulfonamide-derived diuretic antihypertensive agent[1].

In Vitro

Tripamide (less than 10 μg/ml) does not modify the membrane potential and resistance, but does suppress the spike evoked by outward current pulses in the presence of 3-5 mM TEA[1].
In the mesenteric artery, Tripamide suppresses the amplitude of e.j.ps evoked by perivascular nerve stimulation. However, the facilitation process produced by repetitive stimulation is less affected by Tripamide[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In rats loaded orally with 25 ml/kg of normal saline, Tripamide (0.6-160 mg/kg) increases urine volume and sodium and chloride excretion in a dose-dependent fashion. Only at a dose of 160 mg/kg, there an increase in potassiumexcretion in rats[2].
Tripamide has anti-hypertensive effects, during administration to spontaneously hypertensive rats at a dose of 10 mg/kg/day for 4 weeks, tripamide doubled urine volume and sodium excretion, while potassium excretion is increased by <50% in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

369.87

Formula

C₁₆H₂₀ClN₃O₃S

CAS No.
SMILES

O=C(C(C=C1)=CC([S](N)(=O)=O)=C1Cl)NN2C[[email protected]@]3([H])[[email protected]](C2)([H])[[email protected]@H]4C[[email protected]]3CC4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TripamidePotassium ChannelKcsAAntihypertensivediureticprimary hypertensionpotassium excretionInhibitorinhibitorinhibit

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Tripamide
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