1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. Methyclothiazide

Methyclothiazide 

Cat. No.: HY-B0562 Purity: 99.72%
Handling Instructions

Methyclothiazide is an orally active antihypertensive agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine (HY-13715). Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro.

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Methyclothiazide Chemical Structure

Methyclothiazide Chemical Structure

CAS No. : 135-07-9

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 74 In-stock
Estimated Time of Arrival: December 31
10 mg USD 67 In-stock
Estimated Time of Arrival: December 31
25 mg USD 135 In-stock
Estimated Time of Arrival: December 31
50 mg USD 230 In-stock
Estimated Time of Arrival: December 31
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Description

Methyclothiazide is an orally active antihypertensive agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine (HY-13715). Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro[1][2][3].

IC50 & Target

IC50: voltage-dependent Ca-channel (VDCC)

In Vitro

Methyclothiazide (0-100 μM) induces endothelium-dependent inhibition of the vasoconstrictor responses to NE and AVP only in aortas from SHR, and the maximal vasoconstrictive effect of Norepinephrine (HY-13715) and arginine vasopressin (AVP) is decreased by 59% and 32.3 %, respectively[1].
Methyclothiazide (0-100 μM) induces inhibitory effect on the contractile response to Norepinephrine (HY-13715) is abolished by N-nitro-L-arginine (NOLA) but not indomethacin[1].
Methyclothiazide (100 μM) affects the vascular responses to extracellular Ca2+ under high-K+ depolarizing conditions. It can reduce Ca2+ contracture in a high-K+, Ca2+-free solution. The maximal contracture is reduced by 90.4%[1].

Molecular Weight

360.24

Formula

C₉H₁₁Cl₂N₃O₄S₂

CAS No.

135-07-9

SMILES

O=S(C1=C(Cl)C=C(C2=C1)NC(CCl)N(C)S2(=O)=O)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 72 mg/mL (199.87 mM; Need ultrasonic and warming)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7759 mL 13.8796 mL 27.7593 mL
5 mM 0.5552 mL 2.7759 mL 5.5519 mL
10 mM 0.2776 mL 1.3880 mL 2.7759 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

MethyclothiazideCarbonic AnhydraseCarbonate dehydratasehighbloodpressure?stroke,?heart attack,thiazide diureticsedemaInhibitorinhibitorinhibit

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Methyclothiazide
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HY-B0562
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