1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Deserpidine

Deserpidine (Synonyms: Harmonyl)

Cat. No.: HY-107339 Purity: 98.82%
Handling Instructions

Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex.

For research use only. We do not sell to patients.

Deserpidine Chemical Structure

Deserpidine Chemical Structure

CAS No. : 131-01-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 210 In-stock
Estimated Time of Arrival: December 31
5 mg USD 165 In-stock
Estimated Time of Arrival: December 31
10 mg USD 270 In-stock
Estimated Time of Arrival: December 31
25 mg USD 540 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex[1][2][3].

IC50 & Target

Angiotensin converting enzyme (ACE)[3]

In Vitro

Deserpidine is an effective ganglionic blocking agent, which differs from Reserpine only by the absence of a methoxy group at C-11. Deserpidine has been used in the treatment of hypertension and psychosis. In addition, Deserpidine appears to act as a controller of other cardiac disorders[1][2].

Molecular Weight

578.65

Formula

C₃₂H₃₈N₂O₈

CAS No.

131-01-1

SMILES

COC([[email protected]]1[[email protected]@]2([H])C[[email protected]]3([H])C4=C(CCN3C[[email protected]@]2([H])C[[email protected]@H](OC(C5=CC(OC)=C(OC)C(OC)=C5)=O)[[email protected]@H]1OC)C6=CC=CC=C6N4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (172.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7282 mL 8.6408 mL 17.2816 mL
5 mM 0.3456 mL 1.7282 mL 3.4563 mL
10 mM 0.1728 mL 0.8641 mL 1.7282 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.32 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.82%

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Keywords:

DeserpidineHarmonylAngiotensin-converting Enzyme (ACE)AlkaloidReserpineantihypertensivetranquilizeradrenalcortexInhibitorinhibitorinhibit

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Deserpidine
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HY-107339
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