131-01-1
131-01-1
Chemical Structure
Deserpidine
Synonym(s): Harmonyl
- CAS No.: 131-01-1
- Formula:C32H38N2O8
- Molecular Weight:578.65
IUPAC Name: methyl (1S,2R,3R,4aS,13bR,14aS)-2-methoxy-3-((3,4,5-trimethoxybenzoyl)oxy)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
InChIKey: CVBMAZKKCSYWQR-WCGOZPBSSA-N
SMILES: COC([C@H]1[C@@]2([H])C[C@]3([H])C4=C(CCN3C[C@@]2([H])C[C@@H](OC(C5=CC(OC)=C(OC)C(OC)=C5)=O)[C@@H]1OC)C6=CC=CC=C6N4)=O
Biological Activity: Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Deserpidine | 98.37% | Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Deserpidine (Standard) | ≥98% | Deserpidine (Standard) is the analytical standard of Deserpidine. This product is intended for research and analytical applications. Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Deserpidine hydrochloride | Deserpidine hydrochloride (Harmonyl hydrochloride) is an antihypertensive compound that competitively inhibits the activity of angiotensin converting enzyme (ACE). Deserpidine hydrochloride competes with angiotensin I for ACE, preventing the conversion of angiotensin I to angiotensin II, thereby lowering blood pressure. Deserpidine hydrochloride can also reduce angiotensin II-induced aldosterone secretion from the adrenal cortex. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Methyl reserpate | Methyl reserpate (NSC 81464) is a Yohimbine (HY-12715) type alkaloid that can be isolated from Rauwolfia vomitoria roots and leaves. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Metoserpate hydrochloride | Metoserpate hydrochloride is a reserpine-type sedative for poultry. Metoserpate hydrochloride reduces fear-related tonic immobility responses in chicks, inhibits neonatal imprinting approach behavior in an age-dependent manner, and controls hysteria in pullet flocks after administration via drinking water. Metoserpate hydrochloride can be used in studies related to avian fear, stress, imprinting learning and behavioral regulation. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Methoserpidine | Methoserpidine is an active compound. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Bishomoreserpine | Bishomoreserpine is a reserpine analog with potent inhibitory effect. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Rescinnamine | 95.83% | Rescinnamine is a derivative of the indole alkaloid reserpine. Rescinnamine shows sedative effects. Rescinnamine can be used for hypertension research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Reserpine hydrochloride | 99.85% | Reserpine hydrochloride is an inhibitor of the vesicular monoamine transporter 2 (VMAT2). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Reserpine (Standard) | 99.46% | Reserpine (Standard) is the analytical standard of Reserpine. This product is intended for research and analytical applications. Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Reserpine-d9 | 96.84% | Reserpine-d9 is the deuterium labeled Reserpine. Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Syrosingopine | 99.52% | Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Varchi G, et al. Synthesis of deserpidine from reserpine. J Nat Prod. 2005 Nov;68(11):1629-31. [Content Brief]
- [2]. Zhang H, et al. Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):3221-5. [Content Brief]
- [3]. Fulton SC, et al. Comparison of the effectiveness of deserpidine, reserpine, and alpha-methyltyrosine on brain biogenic amines. Fed Proc. 1976 Dec;35(14):2558-62. [Content Brief]
