Synthesis of deserpidine from reserpine

  • J Nat Prod. 2005 Nov;68(11):1629-31. doi: 10.1021/np050179x.
Greta Varchi  1 ,  Arturo Battaglia ,  Cristian Samorì ,  Eleonora Baldelli ,  Bruno Danieli ,  Gabriele Fontana ,  Andrea Guerrini ,  Ezio Bombardelli
Affiliations
  • 1. Istituto CNR per la Sintesi Organica e Fotoreattività ISOF, Area della Ricerca di Bologna, Via P., Gobetti 101, 40129 Bologna, Italy. [email protected]
PMID: 16309312 DOI: 10.1021/np050179x
Abstract

The Rauwolfia Alkaloids reserpine (1) and deserpidine (2), two Alkaloids from Rauwolfia species, have been widely used for their antihypertensive action. Deserpidine (2) is a compound with limited availability from natural sources, and its synthesis from 1 in six steps (41% overall yield) is reported here.

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