Metoserpate hydrochloride

Metoserpate hydrochloride (4 mg/kg on day 1; 2 mg/kg on day 5 and day 9; administered via drinking water; observed for 21 days) controls hysteria in 11 out of 15 pullet flocks, corresponding to 73% of the flocks and 66% of the tested chickens^[2].
Metoserpate hydrochloride (4 mg/kg; administered via drinking water) exerts significant sedative effects approximately 2 h after the initial administration, characterized by reduced activity and drowsiness. The observable sedative effects resolve within 24 h, and no obvious adverse reactions are reported^[2].
Metoserpate hydrochloride (2 mg/kg; subcutaneous injection; single administration 1 h prior to acquisition training) reduces the initiation and running speeds of White Leghorn chicks treated within the first 48 h post-hatch during imprinting acquisition, and this behavioral inhibitory effect remains detectable in drug-free tests at 144 h of age^[4].
Metoserpate hydrochloride reduces the susceptibility of young chickens to tonic immobility and dose-dependently shortens the duration of immobility, with the immobility duration of the control group being more than 3 times that of the optimal dose group^[3].
The acute oral LD₅₀ of Metoserpate hydrochloride is 100 mg/kg in both red-winged blackbirds and starlings. In red-winged blackbirds, its R₅₀ is 0.153%, corresponding to 11.8 mg/kg, with a hazard factor of 0.118^[1].