1. GPCR/G Protein
    Neuronal Signaling
    Autophagy
  2. Adrenergic Receptor
    Autophagy
  3. Carvedilol phosphate hemihydrate

Carvedilol phosphate hemihydrate (Synonyms: BM 14190 phosphate hemihydrate)

Cat. No.: HY-B0006A
Handling Instructions

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker. Carvedilol phosphate hemihydrate inhibits lipid peroxidation with an IC50 of 5 μM. Carvedilol phosphate hemihydrate is a multiple action antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol phosphate hemihydrate is an autophagy inducer that inhibits the NLRP3 inflammasome.

For research use only. We do not sell to patients.

Carvedilol phosphate hemihydrate Chemical Structure

Carvedilol phosphate hemihydrate Chemical Structure

CAS No. : 610309-89-2

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Description

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker[1]. Carvedilol phosphate hemihydrate inhibits lipid peroxidation with an IC50 of 5 μM. Carvedilol phosphate hemihydrate is a multiple action antihypertensive agent with potential use in angina and congestive heart failure[2]. Carvedilol phosphate hemihydrate is an autophagy inducer that inhibits the NLRP3 inflammasome[3].

IC50 & Target

β/α-1 adrenergic receptor[1]
IC50: 5 μM (lipid peroxidation)[2]
Autophagy[3]

In Vitro

Superoxide generation by activated human neutrophils in vitro is inhibited by Carvedilol with an IC50 of 28 μM. Carvedilol is shown to scavenge oxygen free radicals in a cell-free system with an IC50 of 25 μM[2].

Clinical Trial
Molecular Weight

513.48

Formula

C₂₄H₂₆N₂O₄ . H₃PO₄ .₁/₂H₂O

CAS No.

610309-89-2

SMILES

O=P(OO)=O.OC(CNCCOC1=CC=CC=C1OC)COC2=CC=CC(N3)=C2C4=C3C=CC=C4.[HH].[0.5H2O]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Carvedilol phosphate hemihydrateBM 14190 phosphate hemihydrateAdrenergic ReceptorAutophagyBeta Receptorβ/α-1blockerlipidperoxidationantihypertensiveanginacongestiveheartfailureNLRP3inflammasomeInhibitorinhibitorinhibit

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Carvedilol phosphate hemihydrate
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HY-B0006A
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