1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. (S)-Carvedilol

(S)-Carvedilol (Synonyms: (S)-BM 14190)

Cat. No.: HY-B0006B
Handling Instructions

(S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).

For research use only. We do not sell to patients.

(S)-Carvedilol Chemical Structure

(S)-Carvedilol Chemical Structure

CAS No. : 95094-00-1

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Description

(S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX)[1].

IC50 & Target

β/α-1 adrenergic receptor[1]

In Vitro

The β-receptor blocking activity of (S)-Carvedilol is about 100 times greater than that of (R)-Carvedilol, whereas both enantiomers show equipotent potency as α-blockers[1].
(S)-Carvedilol significantly attenuates Doxorubicin (DOX)-induced cell death, apoptotic morphological changes, decrease the mitochondrial membrane potential and oxidative stress responses by increasing the superoxide dismutase and catalase activities, and decreasing malondialdehyde contents and reactive oxygen species levels via the PI3K/AKT/eNO synthase pathway in vitro[1].
(S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs[1].

Molecular Weight

406.47

Formula

C₂₄H₂₆N₂O₄

CAS No.

95094-00-1

SMILES

O[[email protected]@H](CNCCOC1=CC=CC=C1OC)COC2=CC=CC(N3)=C2C4=C3C=CC=C4

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(S)-Carvedilol(S)-BM 14190Adrenergic ReceptorBeta Receptorβ/α-1vascularcardiactoxicityDoxorubicinDOXInhibitorinhibitorinhibit

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