1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. (S)-Carvedilol

(S)-Carvedilol (Synonyms: (S)-BM 14190)

Cat. No.: HY-B0006B Purity: 99.25% ee.: 98.23%
Handling Instructions

(S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).

For research use only. We do not sell to patients.

(S)-Carvedilol Chemical Structure

(S)-Carvedilol Chemical Structure

CAS No. : 95094-00-1

Size Price Stock Quantity
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 820 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (S)-Carvedilol:

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Description

(S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX)[1].

IC50 & Target

β/α-1 adrenergic receptor[1]

In Vitro

The β-receptor blocking activity of (S)-Carvedilol is about 100 times greater than that of (R)-Carvedilol, whereas both enantiomers show equipotent potency as α-blockers[1].
(S)-Carvedilol significantly attenuates Doxorubicin (DOX)-induced cell death, apoptotic morphological changes, decrease the mitochondrial membrane potential and oxidative stress responses by increasing the superoxide dismutase and catalase activities, and decreasing malondialdehyde contents and reactive oxygen species levels via the PI3K/AKT/eNO synthase pathway in vitro[1].
(S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

406.47

Formula

C₂₄H₂₆N₂O₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (492.04 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4602 mL 12.3010 mL 24.6021 mL
5 mM 0.4920 mL 2.4602 mL 4.9204 mL
10 mM 0.2460 mL 1.2301 mL 2.4602 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (12.30 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 5 mg/mL (12.30 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (12.30 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
(S)-Carvedilol
Cat. No.:
HY-B0006B
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