1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis

Nedaplatin 

Cat. No.: HY-13700 Purity: >98.0%
Handling Instructions

Nedaplatin is a derivative of cisplatin and DNA damage agent.

For research use only. We do not sell to patients.

Nedaplatin Chemical Structure

Nedaplatin Chemical Structure

CAS No. : 95734-82-0

Size Price Stock Quantity
10 mM * 1 mL in Water USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Nedaplatin is a derivative of cisplatin and DNA damage agent. Target: Others Nedaplatin(NDP) is a derivative of cisplatin which produced less nausea & vomiting and nephrotoxicity. the effect of NDP on the 7-ethyl-1-hydroxy-CPT (the active form of CPT-11)-induced inhibitory effect on DNA topoisomerase I was examined. The topoisomerase I-inhibitory effect of 7-ethyl-1-hydroxy-CPT was enhanced 10-fold in the presence of NDP at microgram/milliliter concentrations [1]. NDP was developed as a second generation platinum complex. Because it has greater antitumour activity and lower nephrotoxicity than cisplatin (CDDP). At the high-dose of NDP in FN therapy, a reduction of tumour size and long-term tumour-free survival were frequently observed. The survival effect of the combinations of NDP with 5-FU was superior to those of the combination of CDDP with 5-FU. In conclusion, the sequence-dependent antitumour efficacy and toxicity of the combination of NDP or CDDP with 5-FU was demonstrated in this study, and FN therapy appeared to be the most efficient regimen as a clinical therapy [2].

Clinical Trial
Solvent & Solubility
In Vitro: 

H2O : 13.6 mg/mL (44.86 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2984 mL 16.4919 mL 32.9837 mL
5 mM 0.6597 mL 3.2984 mL 6.5967 mL
10 mM 0.3298 mL 1.6492 mL 3.2984 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

303.18

Formula

C₂H₈N₂O₃Pt

CAS No.

95734-82-0

SMILES

O=C1C[O-][Pt+2]([NH3])([NH3])[O-]1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Nedaplatin
Cat. No.:
HY-13700
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Nedaplatin

Cat. No.: HY-13700