1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Nedaplatin

Nedaplatin  (Synonyms: NSC 375101D)

Cat. No.: HY-13700 Purity: ≥98.0%
COA Handling Instructions

Nedaplatin (NSC 375101D) is a derivative of cisplatin and DNA damage agent.

For research use only. We do not sell to patients.

Nedaplatin Chemical Structure

Nedaplatin Chemical Structure

CAS No. : 95734-82-0

Size Price Stock Quantity
5 mg USD 32 In-stock
10 mg USD 46 In-stock
25 mg USD 96 In-stock
50 mg USD 155 In-stock
100 mg USD 248 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Nedaplatin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nedaplatin (NSC 375101D) is a derivative of cisplatin and DNA damage agent.

In Vitro

Nedaplatin (NSC 375101D, NDP) is a derivative of cisplatin which produced less nausea & vomiting and nephrotoxicity. the effect of NDP on the 7-ethyl-1-hydroxy-CPT (the active form of CPT-11)-induced inhibitory effect on DNA topoisomerase I was examined. The topoisomerase I-inhibitory effect of 7-ethyl-1-hydroxy-CPT was enhanced 10-fold in the presence of Nedaplatin (NSC 375101D, NDP) at microgram/milliliter concentrations[1]. Nedaplatin (NSC 375101D, NDP) was developed as a second generation platinum complex. Because it has greater antitumour activity and lower nephrotoxicity than cisplatin (CDDP). At the high-dose of Nedaplatin (NSC 375101D, NDP) in FN therapy, a reduction of tumour size and long-term tumour-free survival were frequently observed. The survival effect of the combinations of Nedaplatin (NSC 375101D, NDP) with 5-FU was superior to those of the combination of CDDP with 5-FU. In conclusion, the sequence-dependent antitumour efficacy and toxicity of the combination of NDP or CDDP with 5-FU was demonstrated in this study, and FN therapy appeared to be the most efficient regimen as a clinical therapy[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

303.18

Formula

C2H8N2O3Pt

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C[O-][Pt+2](N)(N)[O-]1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 8.33 mg/mL (27.48 mM; ultrasonic and warming and heat to 60°C; DMSO can inactivate Nedaplatin's activity)

DMF : < 1 mg/mL (insoluble; DMSO can inactivate Nedaplatin's activity)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2984 mL 16.4919 mL 32.9837 mL
5 mM 0.6597 mL 3.2984 mL 6.5967 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 7.14 mg/mL (23.55 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.2984 mL 16.4919 mL 32.9837 mL 82.4593 mL
5 mM 0.6597 mL 3.2984 mL 6.5967 mL 16.4919 mL
10 mM 0.3298 mL 1.6492 mL 3.2984 mL 8.2459 mL
15 mM 0.2199 mL 1.0995 mL 2.1989 mL 5.4973 mL
20 mM 0.1649 mL 0.8246 mL 1.6492 mL 4.1230 mL
25 mM 0.1319 mL 0.6597 mL 1.3193 mL 3.2984 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nedaplatin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nedaplatin
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