1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis

Nedaplatin 

Cat. No.: HY-13700 Purity: >98.0%
Data Sheet SDS Handling Instructions

Nedaplatin is a derivative of cisplatin and DNA damage agent.

For research use only. We do not sell to patients.
Nedaplatin Chemical Structure

Nedaplatin Chemical Structure

CAS No. : 95734-82-0

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50 mg USD 480 In-stock
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Description

Nedaplatin is a derivative of cisplatin and DNA damage agent. Target: Others Nedaplatin(NDP) is a derivative of cisplatin which produced less nausea & vomiting and nephrotoxicity. the effect of NDP on the 7-ethyl-1-hydroxy-CPT (the active form of CPT-11)-induced inhibitory effect on DNA topoisomerase I was examined. The topoisomerase I-inhibitory effect of 7-ethyl-1-hydroxy-CPT was enhanced 10-fold in the presence of NDP at microgram/milliliter concentrations [1]. NDP was developed as a second generation platinum complex. Because it has greater antitumour activity and lower nephrotoxicity than cisplatin (CDDP). At the high-dose of NDP in FN therapy, a reduction of tumour size and long-term tumour-free survival were frequently observed. The survival effect of the combinations of NDP with 5-FU was superior to those of the combination of CDDP with 5-FU. In conclusion, the sequence-dependent antitumour efficacy and toxicity of the combination of NDP or CDDP with 5-FU was demonstrated in this study, and FN therapy appeared to be the most efficient regimen as a clinical therapy [2].

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References
Molecular Weight

303.18

Formula

C₂H₈N₂O₃Pt

CAS No.

95734-82-0

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: <1 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Nedaplatin
Cat. No.:
HY-13700
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