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Pathways Recommended:	Neuronal Signaling JAK/STAT Signaling

Results for "

hedgehog signaling

" in MedChemExpress (MCE) Product Catalog:

標的別:	Hedgehog (51) Akt (1) Antibiotic (10) Apoptosis (5) ATM/ATR (2) Autophagy (5) Bacterial (8) Biochemical Assay Reagents (1) Caspase (2) CDK (3) Cytochrome P450 (5) EGFR (1) Endogenous Metabolite (8) ERK (1) Fluorescent Dye (1) Fungal (5) Gli (4) Glucocorticoid Receptor (2) GSK-3 (1) HSP (1) Interleukin Related (1) Isotope-Labeled Compounds (5) LDLR (1) Microsomal Triglyceride Transfer Protein (MTP) (1) Parasite (4) Phosphodiesterase (PDE) (1) PPAR (5) RAR/RXR (1) Reference Standards (9) Smo (33) STAT (3) TNF Receptor (1)
研究分野別:	Cancer (61) Cardiovascular Disease (3) Endocrinology (2) Infection (12) Inflammation/Immunology (8) Neurological Disease (1)
クリックケミストリー:	Azide (1)

阻害剤およびアゴニスト

スクリーニングライブラリ

蛍光色素

生化学アッセイ試薬

ペプチド

天然物

同位体標識化合物

クリックケミストリー

Targets Recommended: Hedgehog RGS Protein

製品番号	製品名	Target	研究分野	構造式

HY-12848

SAG Maximum Cited Publications 37 Publications Verification	Smo	Cancer
SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-17514

Itraconazole Maximum Cited Publications 24 Publications Verification R51211	Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial	Infection Cancer
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-100224

SANT-1 4 Publications Verification	Smo Hedgehog	Cancer
SANT-1, a potent Smo antagonist, inhibits *Hedgehog* signaling. SANT-1 shows IC₅₀s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively .

HY-122632

Ciliobrevin D 4 Publications Verification	Hedgehog	Cancer
Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro .

HY-12848B

SAG hydrochloride Maximum Cited Publications 37 Publications Verification	Smo	Cancer
SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-113081

1-Methyladenosine 4 Publications Verification	Endogenous Metabolite PPAR Hedgehog	Cancer
1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates *Hedgehog* signaling pathway, driving liver tumorigenesis .

HY-100535

KAAD-Cyclopamine 2 Publications Verification Cyclopamine-KAAD	Smo	Cancer
KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist .

HY-N0247

Saikosaponin B1 2 Publications Verification	Hedgehog Smo STAT Interleukin Related TNF Receptor	Inflammation/Immunology Cancer
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the 5-HT_2C receptor with an EC₅₀ of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer activities thus can be studies in research for cancers such as Medulloblastoma (MB) .

HY-16587

Saridegib IPI-926; Patidegib	Smo	Cancer
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

HY-B0603

Fluticasone	Smo Glucocorticoid Receptor	Infection Inflammation/Immunology Endocrinology
Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC₅₀ value of 99 nM. Fluticasone activates *Hedgehog* signaling and promotes the proliferation of primary neuronal stem or precursor cells .

HY-12848C

SAG dihydrochloride Maximum Cited Publications 37 Publications Verification	Smo	Cancer
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-100790

Ciliobrevin A 3 Publications Verification HPI-4	Hedgehog	Cancer
Ciliobrevin A (HPI-4) is a *hedgehog* (Hh) signaling pathway inhibitor with median inhibitory concentration (IC₅₀) less than 10 μM .

HY-B0877

Halcinonide 1 Publications Verification SQ-18566	Smo Caspase RAR/RXR CDK	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Halcinonide (SQ-18566) is an orally active Smoothened (Smo) agonist. Halcinonide activates the *Hedgehog* signaling pathway by binding to Smo and promoting its internalization and expression, thereby activating Gli transcription factors. Halcinonide not only stimulates cell proliferation, increases the expression of cyclin D2/CDK6 and inhibits the degradation of caspase-3, but also suppresses Bcl-2/Bax-mediated apoptosis, oxidative stress and inflammatory responses. Halcinonide activates RxRγ to upregulate the expression of myelin genes, thereby reducing cerebral infarction and improving behavioral deficits. Halcinonide has been used in studies related to multiple sclerosis and ischemic stroke .

HY-B0508

Ornidazole 2 Publications Verification Ro 7-0207	Bacterial Parasite Antibiotic Hedgehog	Infection Cancer
Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease .

HY-100515

Robotnikinin 3 Publications Verification	Hedgehog	Inflammation/Immunology
Robotnikinin is a small molecule capable of binding to and inhibiting the activity of *Sonic Hedgehog* (Shh)** signaling up stream of Smo .

HY-18366A

RU-SKI 43 hydrochloride 2 Publications Verification	Hedgehog	Cancer
RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity .

HY-17514S

Itraconazole-d5 R51211-d₅	Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic	Infection Cancer
Itraconazole-d₅ is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects .

HY-N6954

Garcinone C 2 Publications Verification	ATM/ATR STAT CDK Hedgehog	Inflammation/Immunology Cancer
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of *Hedgehog* signaling pathway. Garcinone C is orally active .

HY-12317

GSA-10	Smo Hedgehog	Cancer
GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development .

HY-113081R

1-Methyladenosine (Standard)	Reference Standards Endogenous Metabolite PPAR Hedgehog	Cancer
1-Methyladenosine (Standard) is the analytical standard of 1-Methyladenosine. This product is intended for research and analytical applications. 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates *Hedgehog* signaling pathway, driving liver tumorigenesis . In Vitro:Compared to surrounding tumor tissues, 1-methyladenosine methylation in RNA is aberrantly elevated in hepatocellular carcinoma (HCC) cell lines and liver cancer stem cells (CSCs). Methylated 1-methyladenosine can promote cholesterol synthesis and activate the Hedgehog signaling pathway by enhancing the translation of PPARδ in liver CSCs, ultimately driving the self-renewal and tumorigenesis of liver cancer stem cells .

HY-17514S1

Itraconazole-d3 R51211-d₃	Antibiotic Autophagy Bacterial Cytochrome P450 Fungal Hedgehog	Infection Cancer
Itraconazole-d₃ (R51211-d₃) is the deuterium labeled Itraconazole (HY-17514) . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.

HY-107551

Hh Pathway-IN-1	Hedgehog Gli	Cancer
Hh Pathway-IN-1, a Hedgehog (Hh) pathway inhibitor, is a potent Gli antagonist. Hh Pathway-IN-1 inhibits Hh pathway functional with an IC₅₀ value of 1.1 µM in C3H10T1/2 cells. Hh Pathway-IN-1 does not inhibit Wnt signaling. Hh Pathway-IN-1 shows anti-proliferative activity. Hh Pathway-IN-1 decreases the GLI1 mRNA expression. Hh Pathway-IN-1 inhibits colony formation in a dose-dependent manner .

HY-177291

LAB687	Microsomal Triglyceride Transfer Protein (MTP) Smo Hedgehog LDLR	Cardiovascular Disease Cancer
LAB687 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC₅₀ of 0.9 nM for apolipoprotein B (apoB) secretion in HepG2 cells. LAB687 also acts as a Smoothened (Smo) antagonist, with IC₅₀ values of 2.48 μM and 3.42 μM against mouse and human Smo receptors, respectively. LAB687 reduces triglyceride and low-density lipoprotein cholesterol (LDL-C) levels, and inhibits the *Hedgehog* signaling pathway. LAB687 can be used in studies related to Hedgehog-dependent cancers .

HY-P10875

HL2-m5	Hedgehog	Cancer
HL2-m5 is the inhibitor for the interaction between *sonic hedgehog/patched (Shh/PTCH1)* with K_d of 170 nM for Shh. HL2-m5 inhibits activation of *Hedgehog* signaling pathway and transcription of Gli-controlled gene with an IC₅₀ of 230 nM .

HY-158059

DS-1-38	Hedgehog	Cancer
DS-1-38 is an EYA1 antagonist that blocks Sonic Hedgehog (SHH) signaling. EYA1 is a haloacid dehalogenase phosphatase and transcription factor that regulates tumorigenesis and proliferation in SHH medulloblastoma (SHH-MB) .

HY-12848R

SAG (Standard)	Smo Reference Standards	Cancer
SAG (Standard) is the analytical standard of SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-113965

CUR61414 1 Publications Verification	Hedgehog Smo Apoptosis	Inflammation/Immunology
CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC₅₀ =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a K_i value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells .

HY-12848G

SAG	Smo	Cancer
SAG (GMP) is SAG (HY-12848) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-17514R

Itraconazole (Standard) R51211 (Standard)	Reference Standards Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial	Infection Cancer
Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-18366

RU-SKI 43	Hedgehog	Cancer
RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity .

HY-113081S1

1-Methyladenosine-d3 hydriodide	Isotope-Labeled Compounds Endogenous Metabolite PPAR Hedgehog	Cancer
1-Methyladenosine-d3 hydriodide is the deuterium labeled 1-Methyladenosine (HY-113081). 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis .

HY-16475

TAK-441	Hedgehog	Cancer
TAK-441 is a highly potent and orally active **hedgehog (Hh) signaling inhibitor with an IC₅₀**value of 4.4 nM. TAK-441 has strong antitumor activity in solid tumors .

HY-100224G

SANT-1	Smo Hedgehog	Cancer
SANT-1 (GMP) is SANT-1 (HY-100224) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SANT-1, a potent Smo antagonist, inhibits *Hedgehog* signaling .

HY-12848A

(Rac)-SAG	Smo	Cancer
(Rac)-SAG is an isoform of SAG (HY-12848). SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-123781A

RUSKI-201 dihydrochloride	Hedgehog	Cancer
RUSKI-201 dihydrochloride is a potent and specific Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 0.20 μM. RUSKI-201 dihydrochloride is able to block Hh signaling from Shh overexpressing cells and inhibits Hh palmitoylation. RUSKI-201 dihydrochloride is potential Hhat chemical probe in cells and can used in studies of Hhat catalytic function .

HY-12316R

20(S)-Hydroxycholesterol (Standard) 3 Publications Verification 20α-Hydroxycholesterol (Standard)	Reference Standards Smo Endogenous Metabolite	Cancer
20(S)-Hydroxycholesterol (Standard) is the analytical standard of 20(S)-Hydroxycholesterol. This product is intended for research and analytical applications. 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀ of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

HY-113081AS

1-Methyladenosine-d3 hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite PPAR Hedgehog	Cancer
1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium labeled 1-Methyladenosine (HY-113081). 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates *Hedgehog* signaling pathway, driving liver tumorigenesis .

HY-143400

HSP70-IN-3	HSP Hedgehog	Cancer
HSP70-IN-3 is a potent HSP70 inhibitor (IC₅₀s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1 .

HY-17514S2

Itraconazole-d9 R51211-d₉	Fungal Hedgehog Bacterial Autophagy Cytochrome P450 Antibiotic	Infection
Itraconazole-d₉ is the deuterium labeled Itraconazole . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-162274

Oxazepine	Hedgehog Antibiotic	Infection Cancer
Oxazepine (compound 4a) has antimicrobial viability via binding OMPA/ exo-1,3-beta-glucanase proteins. Oxazepine is a *hedgehog* signaling inhibitor with antitumor viability .

HY-13654

IPI-269609	Smo Hedgehog	Cancer
IPI-269609 is an orally effective Smoothed (SMO) inhibitor that targets the Hedgehog (Hh) signaling pathway. IPI-269609 specifically reduces the ALDH-bright (high aldehyde dehydrogenase activity) cell subset, which is considered the "cancer stem cells" in pancreatic cancer. IPI-269609 significantly inhibits the migration and colony formation of pancreatic cancer cells. IPI-269609 effectively inhibits pancreatic cancer metastasis in a mouse model. IPI-269609 can be used for pancreatic cancer research .

HY-148440

RL-0070933	Hedgehog Smo	Cancer
RL-0070933 is a potent smo cilial modulator with an EC₅₀ value of 0.02 µM. RL-0070933 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway .

HY-B0508S1

Ornidazole-13C2,15N2 Ro 7-0207-¹³C₂,¹⁵N₂	Isotope-Labeled Compounds Bacterial Parasite Antibiotic Hedgehog	Infection
Ornidazole- ¹³C₂, ¹⁵N₂ is the ¹³C, ¹⁵N labeled Ornidazole. Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease .

HY-113081S

1-Methyladenosine-d3	Isotope-Labeled Compounds Endogenous Metabolite PPAR Hedgehog	Cancer
1-Methyl Adenosine-d3 is the deuterium labeled 1-Methyladenosine. 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis .

HY-18287A

MRT-83 hydrochloride	Smo	Cancer
MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease .

HY-N0247R

Saikosaponin B1 (Standard)	Reference Standards Smo	Cancer
Saikosaponin B1 (Standard) is the analytical standard of Saikosaponin B1. This product is intended for research and analytical applications. Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the 5-HT_2C receptor with an EC₅₀ of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer activities thus can be studies in research for cancers such as Medulloblastoma (MB) .

HY-W838042

Hedgehog IN-8	Hedgehog Phosphodiesterase (PDE)	Others
Hedgehog IN-8 effectively inhibits hedgehog signaling and phosphodiesterase activity.

HY-159511

Hedgehog IN-7	Hedgehog	Cancer
Hedgehog IN-7 (Compound 8g), a purine derivative, acts as an inhibitor of *Hedgehog, capable of reducing the expression of Hedgehog* genes and inhibiting *Hedgehog* signaling. Hedgehog IN-7 has significant cytotoxicity and selectivity towards the *Hedgehog* pathway-dependent pancreatic cancer cell Mia-PaCa-2 cells and can be used in the research of pancreatic cancer .

HY-16587A

Saridegib hydrochloride IPI 926 hydrochloride; Patidegib hydrochloride	Smo	Cancer
Saridegib hydrochloride is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

HY-18287

MRT-83	Smo	Cancer
MRT-83 is a potent antagonist of Smo, with an IC₅₀ in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling.

製品番号	製品名

HY-L020

Wnt/Hedgehog/Notch Compound Library

601 compounds

The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development.

MCE designs a unique collection of 601 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.

HY-L017

Stem Cell Signaling Compound Library

2,723 compounds

Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy.

MCE owns a unique collection of 2,723 compounds that can be used for stem cell regulatory and signaling pathway research.

HY-L124

Anti-Prostate Cancer Compound Library

3,419 compounds

Cancer is one of the leading causes of mortality amongst world’s population, in which prostate cancer (PCa) is one of the most encountered malignancies among men. Several molecular mechanisms are involved in prostate cancer development and progression. These include common survival factors in prostate cancer (IGF-1), growth factors (TGF-α, EGF), Wnt, Hedgehog, NF-κB, and mTOR and other signaling pathways. These provide potential therapeutic target in prostate cancer treatment.

MCE offers a unique collection of 3,419 compounds with identified and potential anti-prostate cancer activity. MCE Anti-Prostate Cancer Compound Library is a useful tool for anti-prostate cancer drugs screening and other related research.

HY-L039

Reprogramming Compound Library

3,086 compounds

Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells.

MCE Reprogramming Compound Library contains a unique collection of 3,086 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

製品番号	製品名	Type

HY-12848G

SAG	蛍光色素
SAG (GMP) is SAG (HY-12848) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-100224G

SANT-1	蛍光色素
SANT-1 (GMP) is SANT-1 (HY-100224) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SANT-1, a potent Smo antagonist, inhibits *Hedgehog* signaling .

製品番号	製品名	Type

HY-12848G

SAG	生化学アッセイ試薬
SAG (GMP) is SAG (HY-12848) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-100224G

SANT-1	生化学アッセイ試薬
SANT-1 (GMP) is SANT-1 (HY-100224) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SANT-1, a potent Smo antagonist, inhibits *Hedgehog* signaling .

HY-W414581

7-Keto-27-hydroxycholesterol 3ß,27-Dihydroxy-5-cholesten-7-one	生化学アッセイ試薬
7-Keto-27-hydroxycholesterol (3?,27-Dihydroxy-5-cholesten-7-one) is an important bioactive compound that agonizes the activity of smoothened (SMO) protein in the Hedgehog (Hh) signaling pathway, which is essential for proper cell differentiation in embryonic tissues.

製品番号	製品名	Target	研究分野

HY-P10875

HL2-m5	Hedgehog	Cancer
HL2-m5 is the inhibitor for the interaction between *sonic hedgehog/patched (Shh/PTCH1)* with K_d of 170 nM for Shh. HL2-m5 inhibits activation of *Hedgehog* signaling pathway and transcription of Gli-controlled gene with an IC₅₀ of 230 nM .

製品番号	製品名	Category	Target	構造式

HY-17514

Itraconazole Maximum Cited Publications 24 Publications Verification R51211	Microorganisms Source Classification	Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-113081

1-Methyladenosine 4 Publications Verification	Alkaloids Microorganisms Immune System Disorder Classification of Application Fields Disease markers Other Diseases Endogenous metabolite Disease Research Fields Cancer Source Classification	Endogenous Metabolite PPAR Hedgehog
1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates *Hedgehog* signaling pathway, driving liver tumorigenesis .

HY-N0247

Saikosaponin B1 2 Publications Verification	Structural Classification Classification of Application Fields Umbelliferae Plants Disease Research Fields Saccharides Monosaccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification Cancer	Hedgehog Smo STAT Interleukin Related TNF Receptor
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the 5-HT_2C receptor with an EC₅₀ of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer activities thus can be studies in research for cancers such as Medulloblastoma (MB) .

HY-B0508

Ornidazole 2 Publications Verification Ro 7-0207	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Parasite Antibiotic Hedgehog
Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease .

HY-N6954

Garcinone C 2 Publications Verification	other families Xanthones Classification of Application Fields Garcinia oblongifolia Champ. ex Benth. Guttiferae Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	ATM/ATR STAT CDK Hedgehog
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of *Hedgehog* signaling pathway. Garcinone C is orally active .

HY-113081R

1-Methyladenosine (Standard)	Alkaloids Structural Classification Microorganisms Immune System Disorder Disease markers Endogenous metabolite Cancer Source Classification	Reference Standards Endogenous Metabolite PPAR Hedgehog
1-Methyladenosine (Standard) is the analytical standard of 1-Methyladenosine. This product is intended for research and analytical applications. 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates *Hedgehog* signaling pathway, driving liver tumorigenesis . In Vitro:Compared to surrounding tumor tissues, 1-methyladenosine methylation in RNA is aberrantly elevated in hepatocellular carcinoma (HCC) cell lines and liver cancer stem cells (CSCs). Methylated 1-methyladenosine can promote cholesterol synthesis and activate the Hedgehog signaling pathway by enhancing the translation of PPARδ in liver CSCs, ultimately driving the self-renewal and tumorigenesis of liver cancer stem cells .

HY-17514R

Itraconazole (Standard) R51211 (Standard)	Microorganisms Source Classification	Reference Standards Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial
Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-12316R

20(S)-Hydroxycholesterol (Standard) 3 Publications Verification 20α-Hydroxycholesterol (Standard)	Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Reference Standards Smo Endogenous Metabolite
20(S)-Hydroxycholesterol (Standard) is the analytical standard of 20(S)-Hydroxycholesterol. This product is intended for research and analytical applications. 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀ of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

HY-N0247R

Saikosaponin B1 (Standard)	Structural Classification Umbelliferae Plants Saccharides Monosaccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Reference Standards Smo
Saikosaponin B1 (Standard) is the analytical standard of Saikosaponin B1. This product is intended for research and analytical applications. Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the 5-HT_2C receptor with an EC₅₀ of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer activities thus can be studies in research for cancers such as Medulloblastoma (MB) .

HY-B0508R

Ornidazole (Standard) Ro 7-0207 (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Parasite Antibiotic Hedgehog
Ornidazole (Standard) is the analytical standard of Ornidazole. This product is intended for research and analytical applications. Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease .

HY-N8270

Physalin H	Cardiacglycosides Solanum nigrum Linn. Plants Solanaceae Steroids Source Classification	Hedgehog Endogenous Metabolite
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively .

HY-N6954R

Garcinone C (Standard)	Structural Classification other families Xanthones Garcinia oblongifolia Champ. ex Benth. Guttiferae Phenols Polyphenols Plants Source Classification	Reference Standards ATM/ATR STAT CDK Hedgehog
Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of *Hedgehog* signaling pathway. Garcinone C is orally active .

HY-N9684

Degalactotigonin	Plantaginaceae Digitalis purpurea L. Structural Classification 天然物 Plants Source Classification	EGFR GSK-3 Hedgehog Akt ERK Apoptosis
Degalactotigonin is a saponin-selective inhibitor targeting the EGFR, GSK3β and *Hedgehog/Gli1* pathways and can be isolated from Solanum nigrum (Solanum nigrum). Degalactotigonin inhibits EGFR phosphorylation and the downstream Akt/ERK signaling pathway, and at the same time inhibits the Hedgehog/Gli1 pathway through GSK3β inactivation, thereby inducing cancer cell apoptosis, arresting the cell cycle, and inhibiting migration and invasion. Degalactotigonin can be used in targeted research on malignant tumors such as pancreatic cancer and osteosarcoma .

製品番号	製品名	構造式

HY-17514S

Itraconazole-d5

Itraconazole-d₅ is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects .

HY-17514S1

Itraconazole-d3

Itraconazole-d₃ (R51211-d₃) is the deuterium labeled Itraconazole (HY-17514) . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.

HY-113081S1

1-Methyladenosine-d3 hydriodide

1-Methyladenosine-d3 hydriodide is the deuterium labeled 1-Methyladenosine (HY-113081). 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis .

HY-113081AS

1-Methyladenosine-d3 hydrochloride

1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium labeled 1-Methyladenosine (HY-113081). 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis .

HY-17514S2

Itraconazole-d9

Itraconazole-d₉ is the deuterium labeled Itraconazole . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-B0508S1

Ornidazole-13C2,15N2
Ornidazole- ¹³C₂, ¹⁵N₂ is the ¹³C, ¹⁵N labeled Ornidazole. Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease .

HY-113081S

1-Methyladenosine-d3
1-Methyl Adenosine-d3 is the deuterium labeled 1-Methyladenosine. 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis .

HY-B0508S

Ornidazole-d5
Ornidazole-d₅ is deuterium labeled Ornidazole. Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease .

製品番号	製品名		Classification

HY-159511

Hedgehog IN-7		Azide
Hedgehog IN-7 (Compound 8g), a purine derivative, acts as an inhibitor of *Hedgehog, capable of reducing the expression of Hedgehog* genes and inhibiting *Hedgehog* signaling. Hedgehog IN-7 has significant cytotoxicity and selectivity towards the *Hedgehog* pathway-dependent pancreatic cancer cell Mia-PaCa-2 cells and can be used in the research of pancreatic cancer .

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