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Cat. No.: HY-13654

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IPI-269609

IPI-269609 is an orally effective Smoothed (SMO) inhibitor that targets the Hedgehog (Hh) signaling pathway. IPI-269609 specifically reduces the ALDH-bright (high aldehyde dehydrogenase activity) cell subset, which is considered the "cancer stem cells" in pancreatic cancer. IPI-269609 significantly inhibits the migration and colony formation of pancreatic cancer cells. IPI-269609 effectively inhibits pancreatic cancer metastasis in a mouse model. IPI-269609 can be used for pancreatic cancer research.

For research use only. We do not sell to patients.

CAS No.: 878204-96-7
Formula: C₂₈H₄₁NO₂
Molecular Weight:423.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

IPI-269609 Chemical Structure

CAS No.: 878204-96-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
C3H 10T1/2	EC₅₀	0.2 μM Compound: 9	Inhibition of Hedgehog pathway-dependent oxysterol-induced mouse C3 H10T1/2 cell differentiation assessed as alkaline phosphatase production after 72 hrs Inhibition of Hedgehog pathway-dependent oxysterol-induced mouse C3 H10T1/2 cell differentiation assessed as alkaline phosphatase production after 72 hrs	[PMID: 18842035]
C3H 10T1/2	EC₅₀	0.3 μM Compound: 2, IPI-269609	Inhibition of HedgeHog pathway in mouse C3H10T1/2 cells assessed as inhibition of 20-(S)-hydroxysterol/22-(S)-hydroxysterol-induced osteoblastic differentiation after 72 hrs by Gli-luc reporter assay Inhibition of HedgeHog pathway in mouse C3H10T1/2 cells assessed as inhibition of 20-(S)-hydroxysterol/22-(S)-hydroxysterol-induced osteoblastic differentiation after 72 hrs by Gli-luc reporter assay	[PMID: 19522463]
C3H 10T1/2	EC₅₀	200 nM Compound: 18, (IPI-269609/IPI-609)	Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assay Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assay	[PMID: 19309080]
C3H 10T1/2	EC₅₀	200 nM Compound: 7, IPI-609	Inhibition of SHH-mediated mouse C3H10T1/2 cell differentiation to osteoblasts Inhibition of SHH-mediated mouse C3H10T1/2 cell differentiation to osteoblasts	10.1039/C3MD00334E

Chemical Information

CAS No. 878204-96-7
Molecular Weight 423.63
Formula C₂₈H₄₁NO₂
SMILES

O=C1CC[C@]2(C)[C@@]3([H])CC4=C(C)C[C@]([C@@H]5C)(CC[C@@]4([H])[C@]3([H])CCC2=C1)O[C@@]6([H])[C@@]5([H])NC[C@@H](C)C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Feldmann G, et al. An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. Mol Cancer Ther. 2008 Sep;7(9):2725-35. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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