1. Stem Cell/Wnt
  2. Hedgehog
  3. RU-SKI 43

RU-SKI 43 

Cat. No.: HY-18366
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RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.

For research use only. We do not sell to patients.

RU-SKI 43 Chemical Structure

RU-SKI 43 Chemical Structure

CAS No. : 1043797-53-0

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Description

RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. IC50 value: Target: Hhat inhibitor RU-SKI 43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR.

Molecular Weight

386.55

Formula

C₂₂H₃₀N₂O₂S

CAS No.

1043797-53-0

SMILES

O=C(CNCC(C)CC)N1CCC2=C(C=CS2)C1COC3=CC=CC(C)=C3

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RU-SKI 43
Cat. No.:
HY-18366
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