1. Stem Cell/Wnt
  2. Hedgehog
  3. RU-SKI 43

RU-SKI 43 

Cat. No.: HY-18366
Handling Instructions

RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.

For research use only. We do not sell to patients.

RU-SKI 43 Chemical Structure

RU-SKI 43 Chemical Structure

CAS No. : 1043797-53-0

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Description

RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. IC50 value: Target: Hhat inhibitor RU-SKI 43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

386.55

Formula

C₂₂H₃₀N₂O₂S

CAS No.

1043797-53-0

SMILES

O=C(CNCC(C)CC)N1CCC2=C(C=CS2)C1COC3=CC=CC(C)=C3

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Product Name:
RU-SKI 43
Cat. No.:
HY-18366
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RU-SKI 43

Cat. No.: HY-18366