1043797-53-0
1043797-53-0
Chemical Structure
RU-SKI 43
- CAS No.: 1043797-53-0
- Formula:C22H30N2O2S
- Molecular Weight:386.55
IUPAC Name: 2-((2-methylbutyl)amino)-1-(4-((m-tolyloxy)methyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethan-1-one
InChIKey: AEENEMOEBJOKGN-UHFFFAOYSA-N
SMILES: O=C(CNCC(C)CC)N1CCC2=C(C=CS2)C1COC3=CC=CC(C)=C3
Biological Activity: RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity[1].
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RU-SKI 43 | RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity. | |||||||||||||||||||||
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