1. Stem Cell/Wnt
  2. Hedgehog

RU-SKI 43 hydrochloride (Synonyms: Hhat Inhibitor)

Cat. No.: HY-18366A Purity: >98.0%
Handling Instructions

RU-SKI 43 Hcl is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.

For research use only. We do not sell to patients.

RU-SKI 43 hydrochloride Chemical Structure

RU-SKI 43 hydrochloride Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
5 mg USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 192 In-stock
Estimated Time of Arrival: December 31
50 mg USD 828 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of RU-SKI 43 hydrochloride:

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  • Technical Information

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  • References

Description

RU-SKI 43 Hcl is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. IC50 value: Target: Hhat inhibitor RU-SKI 43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 51 mg/mL (120.56 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3640 mL 11.8201 mL 23.6401 mL
5 mM 0.4728 mL 2.3640 mL 4.7280 mL
10 mM 0.2364 mL 1.1820 mL 2.3640 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

423.01

Formula

C₂₂H₃₁ClN₂O₂S

SMILES

[H]Cl.O=C(CNCC(C)CC)N1CCC2=C(C=CS2)C1COC3=CC=CC(C)=C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
RU-SKI 43 hydrochloride
Cat. No.:
HY-18366A
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RU-SKI 43 hydrochloride

Cat. No.: HY-18366A