KAAD-Cyclopamine
Based on 2 publication(s) in Google Scholar
KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist.
For research use only. We do not sell to patients.
- Purity: 95%
- CAS No.: 306387-90-6
- Formula: C44H63N3O4
- Molecular Weight:697.99
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) KAAD-Cyclopamine
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Biological Activity
KAAD-Cyclopamine inhibits pathway activation induced by 1 μM purmorphamine with an IC50 of 3 nM, wheras this cyclopamine derivative has an IC50 of 100 nM in Shh-LIGHT2 cells stimulated with 10 μM purmorphamine[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 306387-90-6
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Appearance Solid
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Molecular Weight 697.99
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Formula C44H63N3O4
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Color White to light yellow
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SMILES
C[C@H]([C@@](N1CCNC(CCCCCNC(CCC2=CC=CC=C2)=O)=O)([H])[C@](C[C@H](C)C1)([H])O3)[C@@]43C(C)=C(C[C@@]5([H])[C@@]6([H])CC=C(C7)[C@@]5(CCC7=O)C)[C@@]6([H])CC4
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Synonyms
Cyclopamine-KAAD
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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J Mol Histol
Identification of the oncogenic role of centromere protein M in non-small cell lung cancer via CDC20/MYBL2/Wnt signaling pathways. [Abstract]2025 Apr 26;56(3):144. PMID: 40285932 -
Solvent & Solubility
DMSO : 5 mg/mL (7.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Surajit Sinha, et al. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol. 2006 Jan;2(1):29-30. [Content Brief]
[2]. Xiaoli Ma, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. 2005 Oct;26(10):1698-705. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4327 mL | 7.1634 mL | 14.3269 mL | 35.8171 mL |
| 5 mM | 0.2865 mL | 1.4327 mL | 2.8654 mL | 7.1634 mL |
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