Degalactotigonin
Degalactotigonin is a saponin-selective inhibitor targeting the EGFR, GSK3β and Hedgehog/Gli1 pathways and can be isolated from Solanum nigrum (Solanum nigrum). Degalactotigonin inhibits EGFR phosphorylation and the downstream Akt/ERK signaling pathway, and at the same time inhibits the Hedgehog/Gli1 pathway through GSK3β inactivation, thereby inducing cancer cell apoptosis, arresting the cell cycle, and inhibiting migration and invasion. Degalactotigonin can be used in targeted research on malignant tumors such as pancreatic cancer and osteosarcoma.
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- CAS No.: 39941-51-0
- Formule: C50H82O22
- Masse moléculaire:1035.17
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Activité biologique
Description
IC50 & Target
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GSK-3β |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
15.44 μM
Compound: DGT
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Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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10.1039/C5MD00502G |
| HepG2 | IC50 |
0.25 μM
Compound: 1, degalactotigonin
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Cytotoxicity against human Hep G2 after 48 hrs by MTT assay
Cytotoxicity against human Hep G2 after 48 hrs by MTT assay
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[PMID: 16933867] |
| MCF7 | IC50 |
1.57 μM
Compound: 1, degalactotigonin
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Cytotoxicity against human MCF7 after 48 hrs by MTT assay
Cytotoxicity against human MCF7 after 48 hrs by MTT assay
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[PMID: 16933867] |
| MCF7 | IC50 |
8.27 μM
Compound: DGT
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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10.1039/C5MD00502G |
| MOLT-4 | IC50 |
11.72 μM
Compound: DGT
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Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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10.1039/C5MD00502G |
| NCI-H460 | IC50 |
4.49 μM
Compound: 1, degalactotigonin
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Cytotoxicity against human NCI-H460 after 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 after 48 hrs by MTT assay
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[PMID: 16933867] |
| SF-268 | IC50 |
3.19 μM
Compound: 1, degalactotigonin
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Cytotoxicity against human SF-268 after 48 hrs by MTT assay
Cytotoxicity against human SF-268 after 48 hrs by MTT assay
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[PMID: 16933867] |
| SK-BR-3 | IC50 |
9.33 μM
Compound: DGT
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Cytotoxicity against human SKBR3 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human SKBR3 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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10.1039/C5MD00502G |
Chemical Information
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CAS No. 39941-51-0
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Masse moléculaire 1035.17
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Formule C50H82O22
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SMILES
C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@H](CO4)C)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6([C@@](C[C@H](CC6)O[C@]7([H])O[C@@H]([C@@H]([C@@H]([C@H]7O)O)O[C@@]8([H])[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O[C@@]9([H])[C@@H]([C@H]([C@@H](CO9)O)O)O)O[C@]%10([H])O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)CO)CO)([H])CC5)C)([H])CC2
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Tuan Anh HL, et al. Degalactotigonin, a Steroidal Glycoside from Solanum nigrum, Induces Apoptosis and Cell Cycle Arrest via Inhibiting the EGFR Signaling Pathways in Pancreatic Cancer Cells. Biomed Res Int. 2018 Dec 16;2018:3120972. [Content Brief]
[2]. Zhao Z, et al. Degalactotigonin, a Natural Compound from Solanum nigrum L., Inhibits Growth and Metastasis of Osteosarcoma through GSK3β Inactivation-Mediated Repression of the Hedgehog/Gli1 Pathway. Clin Cancer Res. 2018 Jan 1;24(1):130-144. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Degalactotigonin Related Classifications
HY-N9684 Related Classifications
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