Degalactotigonin

Cat. No.: HY-N9684: Data Sheet Handling Instructions
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Degalactotigonin is a saponin-selective inhibitor targeting the EGFR, GSK3β and Hedgehog/Gli1 pathways and can be isolated from Solanum nigrum (Solanum nigrum). Degalactotigonin inhibits EGFR phosphorylation and the downstream Akt/ERK signaling pathway, and at the same time inhibits the Hedgehog/Gli1 pathway through GSK3β inactivation, thereby inducing cancer cell apoptosis, arresting the cell cycle, and inhibiting migration and invasion. Degalactotigonin can be used in targeted research on malignant tumors such as pancreatic cancer and osteosarcoma.

For research use only. We do not sell to patients.

Degalactotigonin Chemical Structure

CAS No. : 39941-51-0

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•Related Small Molecules:

•Related Proteins:

View All EGFR Isoform Specific Products:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Akt Akt1 Akt2 Akt3

View All GSK-3 Isoform Specific Products:

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GSK-3 GSK-3α GSK-3β

View All ERK Isoform Specific Products:

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ERK ERK1 ERK2 ERK5 ERK8

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

GSK-3β

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	15.44 μM Compound: DGT	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay	10.1039/C5MD00502G
HepG2	IC₅₀	0.25 μM Compound: 1, degalactotigonin	Cytotoxicity against human Hep G2 after 48 hrs by MTT assay Cytotoxicity against human Hep G2 after 48 hrs by MTT assay	[PMID: 16933867]
MCF7	IC₅₀	1.57 μM Compound: 1, degalactotigonin	Cytotoxicity against human MCF7 after 48 hrs by MTT assay Cytotoxicity against human MCF7 after 48 hrs by MTT assay	[PMID: 16933867]
MCF7	IC₅₀	8.27 μM Compound: DGT	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	10.1039/C5MD00502G
MOLT-4	IC₅₀	11.72 μM Compound: DGT	Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay	10.1039/C5MD00502G
NCI-H460	IC₅₀	4.49 μM Compound: 1, degalactotigonin	Cytotoxicity against human NCI-H460 after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 after 48 hrs by MTT assay	[PMID: 16933867]
SF-268	IC₅₀	3.19 μM Compound: 1, degalactotigonin	Cytotoxicity against human SF-268 after 48 hrs by MTT assay Cytotoxicity against human SF-268 after 48 hrs by MTT assay	[PMID: 16933867]
SK-BR-3	IC₅₀	9.33 μM Compound: DGT	Cytotoxicity against human SKBR3 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human SKBR3 cells assessed as reduction in cell viability after 72 hrs by MTT assay	10.1039/C5MD00502G

Molecular Weight

1035.17

Formula

C₅₀H₈₂O₂₂

CAS No.

39941-51-0

SMILES

C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@H](CO4)C)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6([C@@](C[C@H](CC6)O[C@]7([H])O[C@@H]([C@@H]([C@@H]([C@H]7O)O)O[C@@]8([H])[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O[C@@]9([H])[C@@H]([C@H]([C@@H](CO9)O)O)O)O[C@]%10([H])O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)CO)CO)([H])CC5)C)([H])CC2

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tuan Anh HL, et al. Degalactotigonin, a Steroidal Glycoside from Solanum nigrum, Induces Apoptosis and Cell Cycle Arrest via Inhibiting the EGFR Signaling Pathways in Pancreatic Cancer Cells. Biomed Res Int. 2018 Dec 16;2018:3120972. [Content Brief]

[2]. Zhao Z, et al. Degalactotigonin, a Natural Compound from Solanum nigrum L., Inhibits Growth and Metastasis of Osteosarcoma through GSK3β Inactivation-Mediated Repression of the Hedgehog/Gli1 Pathway. Clin Cancer Res. 2018 Jan 1;24(1):130-144. [Content Brief]