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Cat. No.: HY-153500

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Hedgehog IN-4

Hedgehog IN-4 is a benzamide derivative and also an inhibitor of the Hedgehog signaling pathway, with an IC₅₀ of 0.050 nM.

For research use only. We do not sell to patients.

CAS No.: 1616368-12-7
Formula: C₃₀H₃₀FN₅O₂
Molecular Weight:511.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hedgehog IN-4 Chemical Structure

CAS No.: 1616368-12-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

Hedgehog IN-4 is a benzamide derivative and also an inhibitor of the Hedgehog signaling pathway, with an IC₅₀ of 0.050 nM^[1].

In Vitro

Hedgehog IN-4 (compound 15h) potently inhibits the Hedgehog signaling pathway in NIH3T3 Gli-luciferase reporter cells, with an IC₅₀ of 0.050 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1616368-12-7
Molecular Weight 511.60
Formula C₃₀H₃₀FN₅O₂
SMILES

O=C(NC1=CC(=CC=C1C)CN2CCOCC2)C3=CC=C(NC4=NC=C(C(=N4)C=5C=CC=CC5)C)C(F)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xin M, et al. Introduction of fluorine to phenyl group of 4-(2-pyrimidinylamino)benzamides leading to a series of potent hedgehog signaling pathway inhibitors. Bioorg Med Chem Lett. 2017;27(15):3259-3263. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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