2. Robotnikinin

Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo.

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Robotnikinin Chemical Structure

Robotnikinin Chemical Structure

CAS No. : 1132653-79-2

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Based on 3 publication(s) in Google Scholar

Robotnikinin Related Antibodies

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Description

Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo[1][2].

In Vitro

Robotnikinin demonstrates ShhN-binding capacity at concentrations between 1.56 μM and 25 μM, with a KD of 3.1 μM derived from kinetic data[2].
Robotnikinin (50 µM) prevents the ShhN-induced LC3-II increase[3].
Robotnikinin (5 μM) downregulates classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells, suggesting a link between Hh signaling and the NF-κB pathway in MM[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Robotnikinin Related Antibodies

RT-PCR[4]

Cell Line: NCI-H929 or U266 cells.
Concentration: 5 μM.
Incubation Time: 48 h.
Result: Downregulated classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells.
Molecular Weight

454.95

Formula

C25H27ClN2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1=CC=C(Cl)C=C1)C[C@H](C/C=C/CC2)C(NC[C@@H](C3=CC=CC=C3)OC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Robotnikinin1132653-79-2Inhibitorinhibitorinhibit

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HY-100515
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