1. Stem Cell/Wnt
  2. Hedgehog
  3. Robotnikinin

Robotnikinin 

Cat. No.: HY-100515
Handling Instructions

Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo.

For research use only. We do not sell to patients.

Robotnikinin Chemical Structure

Robotnikinin Chemical Structure

CAS No. : 1132653-79-2

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Description

Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo[1][2].

In Vitro

Robotnikinin demonstrates ShhN-binding capacity at concentrations between 1.56 μM and 25 μM, with a KD of 3.1 μM derived from kinetic data[2].
Robotnikinin (50 µM) prevents the ShhN-induced LC3-II increase[3].
Robotnikinin (5 μM) downregulates classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells, suggesting a link between Hh signaling and the NF-κB pathway in MM[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[4]

Cell Line: NCI-H929 or U266 cells.
Concentration: 5 μM.
Incubation Time: 48 h.
Result: Downregulated classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells.
Molecular Weight

454.95

Formula

C₂₅H₂₇ClN₂O₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Robotnikinin
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HY-100515
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