2. Stem Cell/Wnt Apoptosis
  3. Hedgehog Smo Apoptosis
  4. CUR61414

CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC50 =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a Ki  value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.

For research use only. We do not sell to patients.

CUR61414 Chemical Structure

CUR61414 Chemical Structure

CAS No. : 334998-36-6

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 154 In-stock
Solution
10 mM * 1 mL in DMSO USD 154 In-stock
Solid
5 mg USD 140 In-stock
10 mg USD 230 In-stock
50 mg USD 820 In-stock
100 mg USD 1350 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

CUR61414 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE CUR61414

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC50 =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a Ki  value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells[1][2].

IC50 & Target

Hedgehog inhibitor[1]
In Vitro

CUR61414 is able to arrest proliferation of basal cells within the BCC-like lesions and induce cells to undergo apoptosis resulting in complete regression of the lesions, without affecting neighboring skin cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CUR61414 Related Antibodies
In Vivo

CUR61414 cause regression of these lesions in the mice, which are exposed to UV light irradiation for 6-9 months, producing many microscopic BCC-like basaloid lesions throughout their skin. Moreover,a significant increase in apoptotic nuclei can be seen in basaloid nests after CUR61414 treatment and no overt toxicity is observed in the skin surrounding the lesions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

550.69

Formula

C31H42N4O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C)(C)CC(N([C@@H]1CN(CC2=CC=C(OCO3)C3=C2)[C@H](C(N4CCNCC4)=O)C1)CC5=CC=CC(OC)=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (181.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8159 mL 9.0795 mL 18.1590 mL
5 mM 0.3632 mL 1.8159 mL 3.6318 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.04%

COA (256 KB) HNMR (284 KB) LCMS (260 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8159 mL 9.0795 mL 18.1590 mL 45.3976 mL
5 mM 0.3632 mL 1.8159 mL 3.6318 mL 9.0795 mL
10 mM 0.1816 mL 0.9080 mL 1.8159 mL 4.5398 mL
15 mM 0.1211 mL 0.6053 mL 1.2106 mL 3.0265 mL
20 mM 0.0908 mL 0.4540 mL 0.9080 mL 2.2699 mL
25 mM 0.0726 mL 0.3632 mL 0.7264 mL 1.8159 mL
30 mM 0.0605 mL 0.3027 mL 0.6053 mL 1.5133 mL
40 mM 0.0454 mL 0.2270 mL 0.4540 mL 1.1349 mL
50 mM 0.0363 mL 0.1816 mL 0.3632 mL 0.9080 mL
60 mM 0.0303 mL 0.1513 mL 0.3027 mL 0.7566 mL
80 mM 0.0227 mL 0.1135 mL 0.2270 mL 0.5675 mL
100 mM 0.0182 mL 0.0908 mL 0.1816 mL 0.4540 mL
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CUR61414 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CUR61414334998-36-6CUR 61414CUR-61414HedgehogSmoApoptosisSmoothenedBCCbasal cell carcinoma,Inhibitorinhibitorinhibit

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