1. Stem Cell/Wnt
    Apoptosis
  2. Hedgehog
    Smo
    Apoptosis
  3. CUR61414

CUR61414 

Cat. No.: HY-113965 Purity: >99.0%
Handling Instructions

CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC50 =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a Ki  value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.

For research use only. We do not sell to patients.

CUR61414 Chemical Structure

CUR61414 Chemical Structure

CAS No. : 334998-36-6

Size Stock
1 mg   Get quote  
5 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC50 =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a Ki  value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells[1][2].

IC50 & Target

Hedgehog inhibitor[1]

In Vitro

CUR61414 is able to arrest proliferation of basal cells within the BCC-like lesions and induce cells to undergo apoptosis resulting in complete regression of the lesions, without affecting neighboring skin cells[1].

In Vivo

CUR61414 cause regression of these lesions in the mice, which are exposed to UV light irradiation for 6-9 months, producing many microscopic BCC-like basaloid lesions throughout their skin. Moreover,a significant increase in apoptotic nuclei can be seen in basaloid nests after CUR61414 treatment and no overt toxicity is observed in the skin surrounding the lesions[1].

Molecular Weight

550.69

Formula

C₃₁H₄₂N₄O₅

CAS No.

334998-36-6

SMILES

CC(C)(C)CC(N([[email protected]@H]1CN(CC2=CC=C(OCO3)C3=C2)[[email protected]](C(N4CCNCC4)=O)C1)CC5=CC=CC(OC)=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CUR61414CUR 61414CUR-61414HedgehogSmoApoptosisSmoothenedBCCbasal cell carcinoma,Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
CUR61414
Cat. No.:
HY-113965
Quantity:
MCE Japan Authorized Agent: