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Results for "

stress resistance

" in MedChemExpress (MCE) Product Catalog:

54

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2

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1

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2

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4

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20

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2

Isotope-Labeled Compounds

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13817
    IU1
    20+ Cited Publications

    		 Deubiquitinase Autophagy Apoptosis Cardiovascular Disease Neurological Disease Endocrinology Cancer
    IU1 is a selective, reversible USP14 inhibitor with an IC50 of 4-5 μM. IU1 binds USP14’s catalytic cleft to block deubiquitinase activity. IU1 induces calpain-dependent Tau cleavage, causes ATP deficits, reduces E1~Ub thioester levels and 26S proteasome assembly. IU1 enhances 26S proteasome chymotrypsin-like activity, modulates LC3B-dependent autophagy flux, reduces cancer cell proliferation and migration, and blocks G0/G1 to S phase cell cycle transition in follicular thyroid cancer cells. IU1 activates autophagy-lysosomal and ubiquitin-proteasome pathways, triggers apoptosis, and reduces cervical cancer cell growth. IU1 enhances degradation of proteasome substrates linked to neurodegenerative disease, accelerates oxidized protein degradation, and increases oxidative stress resistance. IU1 can be used for the research of Alzheimer’s disease, follicular thyroid cancer, ischemic stroke, cervical cancer, and neurodegenerative disease .
    IU1
  • HY-122464
    (±)-Jasmonic acid

    		Herbicide Others
    (±)-Jasmonic acid is an endogenous growth regulator closely related to plant resistance to abiotic stresses, used to activate defense responses to wounding, herbivory, and pathogen attacks. (±)-Jasmonic acid does not play an independent regulatory role, but works in a complex signaling network with other plant hormone signaling pathways. In addition, (±)-Jasmonic acid can also reduce chlorophyll levels in green and etiolated barley leaf segments and inhibit the elongation of rice seedlings .
    (±)-Jasmonic acid
  • HY-W012722
    4-Methyl-2-oxopentanoic acid
    1 Publications Verification

    α-Ketoisocaproic acid

    		 Endogenous Metabolite Autophagy mTOR SOD Neurological Disease Metabolic Disease
    4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid also causes oxidative damage, leading to cognitive deficits, inhibits α-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis. 4-Methyl-2-oxopentanoic acid can be used in the study of maple syrup urine disease .
    4-Methyl-2-oxopentanoic acid
  • HY-125848
    Ginsenoside F2

    		Apoptosis AMPK PPAR p38 MAPK PI3K Akt GSK-3 Reactive Oxygen Species (ROS) SOD Caspase Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Ginsenoside F2 is an orally active bioactive compound that participates in the regulation of metabolism and inflammation. Ginsenoside F2 promotes the phosphorylation of AMPK and ACC, binds to PPARγ, inhibits the phosphorylation of MAPK, activates the PI3K/AKT/GSK-3β pathway, reduces GLRX expression, and regulates lipid metabolism. Ginsenoside F2 reduces ROS production and MDA levels, restores SOD activity in cells, and alleviates oxidative stress. Ginsenoside F2 induces cell apoptosis (Apoptosis) and increases the number of cleaved caspase-3-positive cells. Ginsenoside F2 reduces body weight gain, adipose tissue weight and serum lipid levels in obese mice, and activates the hepatic AMPK signaling pathway and the expression of antioxidant enzymes. Ginsenoside F2 alleviates atopic dermatitis in mice by inhibiting inflammation and reshaping the gut microbiota . Ginsenoside F2 is applicable to research related to insulin resistance, obesity, atopic dermatitis, liver cancer, glioblastoma and glioma .
    Ginsenoside F2
  • HY-B0633C
    Hyaluronic acid (Mw:1000-2000Da)

    		Biochemical Assay Reagents Interleukin Related Atg8/LC3 Inflammation/Immunology
    Hyaluronic acid (Mw: 1000-2000 Da) is a long-chain unbranched polysaccharide with a molecular weight of 1000-2000 Da. Hyaluronic acid (Mw: 2000 Da) inhibits IL-1β expression and increases LC3-II. Hyaluronic acid (Mw: 1000-2000Da) can regulate tissue homeostasis and stress resistance, promote angiogenesis and tissue remodeling. Hyaluronic acid (Mw: 1000-2000 Da) has good biocompatibility and biodegradability, and can be used in drug delivery systems and tissue engineering. Hyaluronic acid (Mw: 2000 Da) can reduce facial skin blemishes and sagging .
    Hyaluronic acid (Mw:1000-2000Da)
  • HY-N2468
    Xylobiose

    1,4-β-D-Xylobiose; 1,4-D-Xylobiose

    		 TNF Receptor Claudin HSP Metabolic Disease Inflammation/Immunology
    Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .
    Xylobiose
  • HY-N3021
    D-chiro-Inositol

    		Endogenous Metabolite NF-κB TNF Receptor FOXO Microtubule/Tubulin Metabolic Disease
    D-chiro-Inositol is a stereoisomer of inositol that exhibits activities such as improving glucose metabolism, anti-tumor effects, anti-inflammatory properties, and antioxidant activity. D-chiro-Inositol effectively alleviates cholestasis by enhancing bile acid secretion and reducing oxidative stress. D-chiro-Inositol improves insulin resistance, lowers hyperglycemia and circulating insulin levels, reduces serum androgen levels, and ameliorates some metabolic abnormalities associated with X syndrome by mimicking the action of insulin. Additionally, D-chiro-Inositol can induce a reduction in pro-inflammatory factors (such as Nf-κB) and cytokines (such as TNF-α), thereby exerting anti-inflammatory effects. D-chiro-Inositol may be used in the study of liver cirrhosis, breast cancer, type 2 diabetes, and polycystic ovary syndrome .
    D-chiro-Inositol
  • HY-Y0399
    L-Norvaline

    Norvaline

    		 Amyloid-β TNF Receptor Arginase Neurological Disease Metabolic Disease
    L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease .
    L-Norvaline
  • HY-P10533
    Cysteine peptide

    		Tyrosinase Others
    Cysteine peptide is a tyrosinase inhibitor with skin-whitening, antioxidant and multi-regulatory activities. Cysteine peptide inhibits enzyme activity and blocks melanin transport, effectively reducing UV-B-induced skin erythema and pigmentation. Cysteine peptide synergistically maintains skin health by quenching ROS, resisting oxidative stress and promoting pheomelanin production. Cysteine peptide safely prevents daily ultraviolet damage and supports moderate sun exposure for vitamin D synthesis. Cysteine peptide also acts as a plant signaling factor to regulate vegetative growth, development and stress resistance responses .
    Cysteine peptide
  • HY-P1934
    Cyclo(Phe-Pro)
    5+ Cited Publications

    Cyclo(phenylalanylprolyl); A-64863

    		 HCV Bacterial Antibiotic Reactive Oxygen Species (ROS) Infection
    Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance .
    Cyclo(Phe-Pro)
  • HY-N9497
    Galactinol

    		Galectin Fungal Infection
    Galactinol is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot .
    Galactinol
  • HY-W116336D
    Zinc oxide, <100 nm particle size

    		Biochemical Assay Reagents Fungal Bacterial Infection Cancer
    Zinc oxide, <100 nm particle size is a nitrate reductase modulator and growth promoter with plant stress resistance activity and oral toxicity. Zinc oxide, <100 nm particle size acts as a nutrient source for maize plants. By enhancing nitrate reductase activity and reducing free proline levels, it significantly improves plant height, root length and dry matter weight of maize, and its growth-promoting effect is comparable to that of traditional zinc sulfate fertilizer. Zinc oxide, <100 nm particle size induces anemia-related and persistent tissue inflammatory damage, leading to obvious histopathological adverse reactions in the stomach, pancreas, eyes and prostate of rats. Zinc oxide, <100 nm particle size acts as a non-toxic antibacterial agent and selective cytotoxin against multiple bacteria, fungi and spores .
    Zinc oxide, <100 nm particle size
  • HY-N2392
    Kukoamine A
    1 Publications Verification

    		 Parasite Lipoxygenase Opioid Receptor Apoptosis Autophagy Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor PGE synthase COX Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Kukoamine A, a spermine alkaloid, is an orally active and brain-penetrant component found in the root barks of Lycium chinense (L. chinense) Miller. Kukoamine A inhibits purified Crithidia fasciculata trypanothione reductase and soybean lipoxygenase, activates μ-opioid receptor. Kukoamine A can inhibt cancer cell proliferation, migration and invasion, cause G0/G1 phase cell cycle arrest and induce apoptosis. Kukoamine A exerts neuroprotective effect and can induce autophagy . Kukoamine A inhibits LPS (HY-D1056)-induced NO, ROS, PGE2, TNF-α, IL-1β, IL-6 production and COX-2 activity. Kukoamine A reverses palmitic acid-induced insulin resistance, lipid accumulation, and oxidative stress via downregulation of Srebp-1c. Kukoamine A can be used for the research of cancer, infection, inflammation, metabolic and neurological disease, such as glioblastoma and Parkinson's disease .
    Kukoamine A
  • HY-114243
    DpC

    		NF-κB JNK Caspase Apoptosis Neurological Disease Cancer
    DpC is a selective, orally active iron chelator with anticancer activity. DpC acts on signaling pathway-related targets such as JNK, NF-κB, and its activity is competitively inhibited by another iron chelator Dp44mT (HY-18973). By chelating intracellular iron and copper ions in tumor cells to form redox-active complexes, DpC induces oxidative stress, activates the JNK, NF-κB pathways and downregulates IκBα, upregulates the expressions of neuroglobin and cytoglobin, activates caspase 3/9 to induce tumor cell apoptosis. It also overcomes P-glycoprotein-mediated multidrug resistance through a lysosome-targeting mechanism, and exhibits broad-spectrum synergistic effects when combined with various chemotherapeutic agents. DpC inhibits tumor metastasis and increases TNF-α levels in the tumor microenvironment to enhance endogenous immune responses. DpC is applicable to the research of various malignancies including neuroblastoma, pancreatic cancer, prostate cancer, lung cancer, and breast cancer .
    DpC
  • HY-12833
    AMZ30
    1 Publications Verification

    		 Phosphatase Akt ERK Others
    AMZ30 is selective protein phosphatase methylesterase-1(PME-1) inhibitor with IC50s of 600 nM and 3.5 µM in human cell lysates and in HEK 293T cells, respectively. AMZ30 shows >100-fold selectivity relative to other serine hydrolases. AMZ30 reduces the demethylated form of PP2A in living cells. AMZ30 attenuates muscle cell differentiation. AMZ30 increases the resistance of U87MG and U251MG glioblastoma cells to t-BHP-induced oxidative stress. AMZ30can be used for the study of glioblastoma .
    AMZ30
  • HY-117391
    AZ-Dyrk1B-33
    2 Publications Verification

    		 DYRK Metabolic Disease Cancer
    AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor, with an IC50 of 7 nM .
    AZ-Dyrk1B-33
  • HY-N6911
    Licorice-saponin H2

    (18β,20α)-Glycyrrhizic acid

    		 Others Metabolic Disease
    Liquorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) is a type of triterpenoid oligosaccharide glycoside found in the Glycyrrhiza genus. Liquorice-saponin H2 accumulates more in the roots of licorice plants under salt stress conditions, suggesting that it may play a role in plant stress resistance .
    Licorice-saponin H2
  • HY-122464A
    Jasmonic acid

    (-)-Jasmonic acid

    		 Drug Derivative Others
    Jasmonic acid ((-)-Jasmonic acid) is a plant growth regulator and a derivative of Linolenic acid (HY-N0728). Jasmonic acid enhances plant resistance and is widely used as a stress protectant. Jasmonic acid is an endogenous plant hormone and a plant growth inhibitor .
    Jasmonic acid
  • HY-N6924
    Zingibroside R1
    1 Publications Verification

    		 HIV PIN1 Fungal GLUT Reactive Oxygen Species (ROS) Infection Neurological Disease Metabolic Disease Cancer
    Zingibroside R1 is an orally active triterpene saponin with multiple biological activities including antioxidant, anti-inflammatory, antiviral, and metabolic regulatory properties. Zingibroside R1 reduces the expression of PIN family members, inhibits the expression of PLT1/PLT2, WOX5, SHR, and SCR, disrupts auxin transport and distribution, triggers plant ROS responses, and inhibits root growth. Zingibroside R1 extends the lifespan of Caenorhabditis elegans, enhances its heat stress resistance, and improves its motor ability. Hydrogel derivatives of Zingibroside R1 inhibit the proliferation of Candida albicans by binding to its β-1,3-glucan and exhibit antifungal activity. Zingibroside R1 inhibits GLUT1-mediated uptake and alleviates liver injury. Zingibroside R1 can be used in research related to neurodegenerative diseases, vulvovaginal candidiasis, acute liver injury, Ehrlich ascites tumor and HIV-1 infection .
    Zingibroside R1
  • HY-148062
    RSS0680

    		PROTACs CDK AAK1 Cyclin G-associated Kinase (GAK) Salt-inducible Kinase (SIK) LIM Kinase (LIMK) Wee1 SnRK Others
    RSS0680 is a small noncoding RNA (sRNA) targeting the mRNA ribosome binding site (RBS) and a PROTAC with protein kinase degradation activity (Pink: FLT3-IN-17 (HY-148070); Black: Linker (HY-W041970); Blue: E3 ligase Ligand (HY-112078)). RSS0680 competitively binds to RBS through the conserved CCUCCUCCC anti-Shine-Dalgarno (aSD) sequence and inhibits the translation initiation of target genes. RSS0680 can interact with the DUF1127 protein CcaF1, regulate its own stability and participate in bacterial oxidative stress defense, enhancing the host's resistance to heat shock and oxidative damage by affecting pathways such as C1 metabolism and pyruvate dehydrogenase complex. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used to study diseases or disorders mediated by aberrant kinase activity and regulatory mechanisms of noncoding RNAs in α-proteobacteria[1][2].
    RSS0680
  • HY-W030562
    Bemethyl

    		Others Inflammation/Immunology
    Bemethyl is a synthetic adaptogen that exhibits actoprotector and antihypoxant activities. Bemethyl has the ability to increase the body's resistance to stress and improve physical endurance. Bemethyl regulatory mechanisms include vasodilation and lowering blood sugar and lactate levels. Bemethyl is an analytical reference standard for adaptogen .
    Bemethyl
  • HY-14790
    Esreboxetine

    (S,S)-(+)-Reboxetine

    		 Adrenergic Receptor Neurological Disease
    Esreboxetine ((S,S)-Reboxetine) is a selective norepinephrine reuptake inhibitor with activity in increasing urethral resistance. Esreboxetine has been reported to be effective in patients with stress urinary incontinence in a Phase IIa clinical study, achieving this effect by increasing urethral closure. The mechanism of action of esreboxetine involves inhibition of norepinephrine transporters in the central and peripheral nervous systems. The peripheral selectivity of esreboxetine helps it significantly increase urethral resistance without penetrating the brain .
    Esreboxetine
  • HY-P2825
    Tyrosine decarboxylase, Microorganism

    TDC; TyrDC

    		 Endogenous Metabolite Others
    Tyrosine decarboxylase, Microorganism (TDC) is a tyrosine decarboxylase produced by microorganisms. Tyrosine decarboxylase is a PLP-dependent enzyme that catalyzes the decarboxylation of L-tyrosine, L-phenylalanine, and L-dopa to produce tyramine, 2-phenethylamine, and dopamine, respectively. Tyrosine decarboxylase mediates acid stress resistance, maintains intracellular pH homeostasis, and generates proton motive force .
    Tyrosine decarboxylase, Microorganism
  • HY-135887
    ZX-29

    		Anaplastic lymphoma kinase (ALK) Apoptosis Autophagy Cancer
    ZX-29 is a potent and selective ALK inhibitor with an IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect .
    ZX-29
  • HY-135258
    Galactinol dihydrate

    		Galectin Fungal Others
    Galactinol dihydrate is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol dihydrate not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol dihydrate has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol dihydrate can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot .
    Galactinol dihydrate
  • HY-110067
    VO-OHPic

    		PTEN Apoptosis Autophagy Ferroptosis Reactive Oxygen Species (ROS) Interleukin Related Akt Keap1-Nrf2 Cardiovascular Disease Inflammation/Immunology Cancer
    VO-OHPic is a reversible, noncompetitive PTEN inhibitor with an human IC50 value of 46 nM. VO-OHPic inhibits PTEN signaling, activates Akt-GSK3β and Nrf-2/HO-1 pathways, induces apoptosis resistance and elevates IL-10 levels. VO-OHPic inhibits autophagy, ferroptosis and oxidative stress. VO-OHPic can be used for the research of acute myocardial infarction, intervertebral disc degeneration, cardiomyopathy and cancer .
    VO-OHPic
  • HY-N10405
    (R)-5-Hydroxy-1,7-diphenyl-3-heptanone

    		Keap1-Nrf2 Metabolic Disease
    (R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that can be found in Alpinia officinarum. (R)-5-Hydroxy-1,7-diphenyl-3-heptanone ameliorates oxidative stress and insulin resistance via activation of Nrf2/ARE pathway .
    (R)-5-Hydroxy-1,7-diphenyl-3-heptanone
  • HY-P10670
    CLE25 Peptide

    		ABA Receptor Others
    CLE25 peptide moves from the roots to the leaves and modulates NCED3 expression in leaves in association with the receptor-like kinases BAM1 and BAM3. CLE25 peptide induces stomatal closure by modulating abscisic acid accumulation and thereby enhances resistance to dehydration stress .
    CLE25 Peptide
  • HY-Y0399S
    L-Norvaline-d5

    		Isotope-Labeled Compounds Amyloid-β TNF Receptor Arginase Neurological Disease Metabolic Disease
    L-Norvaline-d5 is the deuterium labeled L-Norvaline. L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease .
    L-Norvaline-d5
  • HY-Y0399R
    L-Norvaline (Standard)

    		Amyloid-β Reference Standards TNF Receptor Arginase Neurological Disease Metabolic Disease
    L-Norvaline (Standard) is the analytical standard of L-Norvaline (HY-Y0399). This product is intended for research and analytical applications. L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease .
    L-Norvaline (Standard)
  • HY-P2819
    Phosphofructokinase 1

    PFK1

    		 Phosphatase Metabolic Disease
    Phosphofructokinase 1 (PFK1) is a major regulatory enzyme targeting glycolytic pathway. Phosphofructokinase 1 catalyzes the phosphorylation of fructose-6-phosphate (F6P) to fructose-1,6-bisphosphate (F1,6BP) to regulate glycolytic flux. Phosphofructokinase 1 is promising for research of cancer metabolic reprogramming (e.g., hypoxia adaptation, oxidative stress resistance) and metabolic syndromes .
    Phosphofructokinase 1
  • HY-N3021R
    D-chiro-Inositol (Standard)

    		Reference Standards Endogenous Metabolite NF-κB TNF Receptor FOXO Microtubule/Tubulin Metabolic Disease
    D-chiro-Inositol is a stereoisomer of inositol that exhibits activities such as improving glucose metabolism, anti-tumor effects, anti-inflammatory properties, and antioxidant activity. D-chiro-Inositol effectively alleviates cholestasis by enhancing bile acid secretion and reducing oxidative stress. D-chiro-Inositol improves insulin resistance, lowers hyperglycemia and circulating insulin levels, reduces serum androgen levels, and ameliorates some metabolic abnormalities associated with X syndrome by mimicking the action of insulin. Additionally, D-chiro-Inositol can induce a reduction in pro-inflammatory factors (such as Nf-κB) and cytokines (such as TNF-α), thereby exerting anti-inflammatory effects. D-chiro-Inositol may be used in the study of liver cirrhosis, breast cancer, type 2 diabetes, and polycystic ovary syndrome .
    D-chiro-Inositol (Standard)
  • HY-155474
    Me4Phen

    		Apoptosis Cancer
    Me4Phen (compound 3) is an oxygen rhenium (V) complex that depletes mitochondrial membrane potential and upregulates intracellular reactive oxygen species (ROS), leading to endoplasmic reticulum stress-mediated necrosis of cancer cells. Me4Phen is highly lipophilic and effectively overcomes Cisplatin (HY-17394) resistance in a variety of cancer cells .
    Me4Phen
  • HY-N9680
    Coenzyme Q8

    Ubiquinone 8

    		 Endogenous Metabolite Bacterial Infection Inflammation/Immunology
    Coenzyme Q8 (Ubiquinone 8) is an isoprenoid quinone that mediates electron transfer within the aerobic respiratory chain and reduces oxidative stress. Coenzyme Q8 maintains bacterial respiratory function and enhances host resistance to bacterial infection. Coenzyme Q8 stimulates macrophage phagocytosis and increases antibody-producing cells. Coenzyme Q8 can be used in infectious disease research .
    Coenzyme Q8
  • HY-W012722BS
    4-Methyl-2-oxopentanoic acid-d7 sodium

    α-Ketoisocaproic acid-d7 sodium

    		 Endogenous Metabolite Isotope-Labeled Compounds Neurological Disease Metabolic Disease
    4-Methyl-2-oxopentanoic acid-d7 (α-Ketoisocaproic acid-d7) sodium is the deuterium labeled 4-Methyl-2-oxopentanoic acid (HY-W012722).4-Methyl-2-oxopentanoic acid is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways .
    4-Methyl-2-oxopentanoic acid-d7 sodium
  • HY-N2468R
    Xylobiose (Standard)

    1,4-β-D-Xylobiose (Standard); 1,4-D-Xylobiose (Standard)

    		 Reference Standards TNF Receptor Claudin HSP Metabolic Disease Inflammation/Immunology
    Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .
    Xylobiose (Standard)
  • HY-W207699
    MAO-B-IN-46

    		Monoamine Oxidase Amylases Neurological Disease Metabolic Disease Inflammation/Immunology
    MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC50: 26.8 nM), with weak activity against hMAO-A (IC50: 7.2054 μM). MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC50: 19.46 μM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC50 values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance .
    MAO-B-IN-46
  • HY-161521
    PLK1-IN-10

    		Polo-like Kinase (PLK) Cancer
    PLK1-IN-10 (Compound 4Bb) is an orally active PLK1 PBD (polo-box domain) inhibitor. PLK1-IN-10 blocks the interaction of PLK1 with the cell division regulator protein 1 (PRC1) and decreases the protein expression of the CDK1-Cyclin B1 complex. PLK1-IN-10 reacts with glutathione (GSH) to increase cellular oxidative stress, ultimately leading to cell death .
    PLK1-IN-10
  • HY-N6911B
    Licorice-saponin H2 ammonium

    (18β,20α)-Glycyrrhizic acid ammonium

    		 Others Metabolic Disease
    Liquorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) ammonium is a type of triterpenoid oligosaccharide glycoside found in the Glycyrrhiza genus. Liquorice-saponin H2 ammonium accumulates more in the roots of licorice plants under salt stress conditions, suggesting that it may play a role in plant stress resistance .
    Licorice-saponin H2 ammonium
  • HY-N12526
    Isolappaol A

    		Others Others
    Isolappaol A is a natural product that can be isolated from the Arctium lappa. Isolappaol A upregulates the expression of jnk-1, which may promote longevity and stress resistance of C. elegans through the JNK-1-DAF-16 cascade .
    Isolappaol A
  • HY-174411
    Tubulin polymerization-IN-82

    		Microtubule/Tubulin MMP Bcl-2 Family Reactive Oxygen Species (ROS) Caspase Cancer
    Tubulin polymerization-IN-82 is a tubulin inhibitor. Tubulin polymerization-IN-82 inhibits cell migration and invasion, and triggers cell apoptosis through the mitochondria and ER stress mediated pathway. Tubulin polymerization-IN-82 exhibits antitumor activity against drug resistance cancer cells, and inhibits tumor growth, can be used for liver cancer research .
    Tubulin polymerization-IN-82
  • HY-16637B
    Folcysteine

    		Amino Acid Derivatives Others
    Folcysteine ​​is an amino acid derivative containing sulfur. As a biostimulant, folcysteine ​​can promote plant growth and improve plant resistance to adversity. Folcysteine ​​can be used in agricultural research .
    Folcysteine
  • HY-179217
    GSTP1/M2-IN-1

    		JNK Apoptosis Cancer
    GSTP1/M2-IN-1 is a GSTP1/GSTM2 inhibitor(IC50 = 1.56 μM/0.09 μM). GSTP1/M2-IN-1 can activate the JNK pathway and induce cell apoptosis. GSTP1/M2-IN-1 can be used for the study of breast cancer and pancreatic cancer .
    GSTP1/M2-IN-1
  • HY-161647
    Antitumor agent-156

    		Reactive Oxygen Species (ROS) Apoptosis Autophagy Ferroptosis Cancer
    Antitumor agent-156 (Compound 20) causes DNA damage and mitochondrial dysfunction, promotes reactive oxygen species generation, activates endoplasmic reticulum stress, and induce apoptosis, autophagy and ferroptosis. Antitumor agent-156 shows superior antitumor activity against cancer cells including Cisplatin (HY-17394) resistance cells. Antitumor agent-156 displayS good liver-targeting ability .
    Antitumor agent-156
  • HY-159577
    Nic-15

    		PI3K mTOR Akt Cancer
    Nic-15 (compound 4n) is an anti-constrictive agent used to antagonize the hypovascularity of pancreatic tumors. The hypovascularity allows cancer cells to adapt to the nutrient-deficient tumor microenvironment and develop drug resistance. Nic-15 can regulate the PI3K/Akt/mTOR pathway and alleviate ER stress induced by Gemcitabine (HY-17026). Nic-15 can significantly inhibit the migration and colony formation of MIA PaCa-2 and PANC-1 pancreatic cancer cells. The combination of Nic-15 and Gemcitabine can effectively solve the problem of pancreatic tumor resistance. In an in vivo xenograft model, Nic-15 can significantly enhance the efficacy of Gemcitabine .
    Nic-15
  • HY-182751
    ACLY-IN-4

    		ATP Citrate Lyase Inflammation/Immunology
    ACLY-IN-4 is an ATP-citrate lyase (ACLY) inhibitor with an IC50 of 0.022 μM and a Kd of 0.19 μM. ACLY-IN-4 binds to the allosteric binding site of ACLY. ACLY-IN-4 exhibits hypolipidemic, anti-steatotic, insulin sensitivity-improving, anti-oxidative stress, anti-inflammatory and anti-fibrotic activities. ACLY-IN-4 alleviates hepatic steatosis, systemic insulin resistance, oxidative stress, hepatic inflammation and fibrosis. ACLY-IN-4 can be used for the research of metabolic dysfunction-associated steatohepatitis .
    ACLY-IN-4
  • HY-W753416
    14-Hydroxylated brassinosteroid

    		Phytohormone Inflammation/Immunology
    14-Hydroxylated brassinosteroid is a plant growth regulator. 14-Hydroxylated brassinosteroid enhances winter wheat resistance to heat stress, delays heat-induced leaf senescence, maintains leaf water content, promotes grain filling, and mitigates yield loss. 14-Hydroxylated brassinosteroid shows antioxidant activity. 14-Hydroxylated brassinosteroid can be used for the research of plant growth .
    14-Hydroxylated brassinosteroid
  • HY-182750
    ACLY-IN-3

    		ATP Citrate Lyase Inflammation/Immunology
    ACLY-IN-3 is an ATP-citrate lyase (ACLY) inhibitor with an IC50 of 0.036 μM and a target Kd of 0.54 μM. ACLY-IN-3 interacts with the allosteric binding site of ACLY to inhibit its activity. ACLY-IN-3 exhibits excellent lipid-lowering effects and alleviates hepatic inflammation and liver fibrosis. ACLY-IN-3 can be used for the research of metabolic dysfunction-associated steatohepatitis .
    ACLY-IN-3
  • HY-105111
    P-536

    		Parasite Angiotensin-converting Enzyme (ACE) HSV DNA/RNA Synthesis Cardiovascular Disease Metabolic Disease
    P-536 is a ACE inhibitor that also inhibits herpes simplex virus HSV-1 thymidine kinase and Trypanosoma cruzi RNA polymerase. By inhibiting the renin-angiotensin system, downregulating the expression of AT1R and NOX4, and reducing oxidative stress (decreasing plasma hydrogen peroxide (H2O2) and 8-isoprostaglandin levels), P-536 effectively reduces systolic blood pressure and improves vascular reactivity. P-536 also inhibits the replication of DNA/RNA viruses such as HSV-1 by blocking nucleotide metabolism and nucleic acid synthesis, competitively inhibits RNA synthesis in Trypanosoma cruzi, and inhibits amastigote replication, thereby impeding its growth. P-536 is suitable for research on hypertension, insulin resistance, and Chagas disease .
    P-536
  • HY-P11580
    Pap12-6-10

    		Toll-like Receptor (TLR) Bacterial Infection
    Pap12-6-10 is an MD-2 ligand that binds to the hydrophobic pocket of MD-2 to inhibit the dimerization of the TLR4/MD-2 complex and downstream inflammatory signal transduction. Pap12-6-10 also binds to LPS to permeabilize bacterial cell membranes and induce oxidative stress, leading to bacterial death. Pap12-6-10 regulates LPS-induced inflammatory responses through the TLR4 signaling pathway and exhibits antibacterial activity against multidrug-resistant Gram-negative bacteria. Pap12-6-10 shows low tendency to induce drug resistance and low preclinical cytotoxicity, and it prevents organ damage in a mouse model of sepsis. Pap12-6-10 can be used for research related to Gram-negative sepsis and carbapenem-resistant Acinetobacter baumannii infections .
    Pap12-6-10

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