1. Cell Cycle/DNA Damage
  2. Deubiquitinase
  3. IU1

IU1 

Cat. No.: HY-13817 Purity: >98.0%
Handling Instructions

IU1 is a special Usp14 inhibitor with IC50 of 4-5 μM.

For research use only. We do not sell to patients.

IU1 Chemical Structure

IU1 Chemical Structure

CAS No. : 314245-33-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
50 mg USD 276 In-stock
Estimated Time of Arrival: December 31
100 mg USD 492 In-stock
Estimated Time of Arrival: December 31
200 mg USD 864 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

* Please select Quantity before adding items.

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Description

IU1 is a special Usp14 inhibitor with IC50 of 4-5 μM.

IC50 & Target

IC50: 4-5 μM (Usp14)[1]

In Vitro

Usp14, a proteasome-associated deubiquitinating enzyme, can inhibit the degradation of ubiquitin-protein conjugates, in vivo and in vitro. IU1inhibits the catalytic activity of proteasome associated Usp14 in vitro. The IC50 of IU1 for Usp14 is 4-5 μM. IU1 binds specifically to the activated form of Usp14. IU1 can potentially inhibit Usp14 by preventing its docking on the proteasome, but direct tests of this scenario proved negative. Usp14 inhibition is rapidly established upon addition of IU1 and rapidly reversed upon its removal. IU1 also promotes degradation of Sic1, a CDK inhibitor from S. cerevisiae[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 60 mg/mL (199.75 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3292 mL 16.6461 mL 33.2923 mL
5 mM 0.6658 mL 3.3292 mL 6.6585 mL
10 mM 0.3329 mL 1.6646 mL 3.3292 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

300.37

Formula

C₁₈H₂₁FN₂O

CAS No.

314245-33-5

SMILES

CC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
IU1
Cat. No.:
HY-13817
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IU1

Cat. No.: HY-13817