1. Anti-infection
    Metabolic Enzyme/Protease
    Membrane Transporter/Ion Channel
  2. HIV
    HIV Protease
    Cytochrome P450
    P-glycoprotein
  3. Atazanavir sulfate

Atazanavir sulfate (Synonyms: BMS-232632 sulfate)

製品番号: HY-17367A 純度: 99.94%
取扱説明書

Atazanavir sulfate (BMS-232632 sulfate) is a highly selective HIV-1 protease inhibitor for the treatment of HIV infection, and is the first protease inhibitor approved for once-daily administration. Atazanavir sulfate (BMS-232632 sulfate) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp).

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Atazanavir sulfate 構造式

Atazanavir sulfate 構造式

CAS 番号 : 229975-97-7

容量 価格(税別) 在庫状況 数量
無料サンプル (0.5-1 mg)   今すぐ申し込む  
10 mM * 1 mL in DMSO USD 79 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 72 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 144 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 240 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

Other Forms of Atazanavir sulfate:

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製品説明

Atazanavir sulfate (BMS-232632 sulfate) is a highly selective HIV-1 protease inhibitor for the treatment of HIV infection, and is the first protease inhibitor approved for once-daily administration[1]. Atazanavir sulfate (BMS-232632 sulfate) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2].

IC50 & Target

HIV-1 protease[1]
CYP3A4, P-gp[2]

臨床実験
分子量

802.93

分子式

C₃₈H₅₄N₆O₁₁S

CAS 番号

229975-97-7

SMILES

O=C(OC)N[[email protected]@H](C(C)(C)C)C(NN(CC1=CC=C(C2=NC=CC=C2)C=C1)C[[email protected]](O)[[email protected]](CC3=CC=CC=C3)NC([[email protected]](C(C)(C)C)NC(OC)=O)=O)=O.O=S(O)(O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 166 mg/mL (206.74 mM; Need ultrasonic and warming)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2454 mL 6.2272 mL 12.4544 mL
5 mM 0.2491 mL 1.2454 mL 2.4909 mL
10 mM 0.1245 mL 0.6227 mL 1.2454 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.11 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
参考文献

純度: 99.94%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AtazanavirBMS-232632BMS232632BMS 232632HIVHIV ProteaseCytochrome P450P-glycoproteinHuman immunodeficiency virusCYPsP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Inhibitorinhibitorinhibit

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製品名:
Atazanavir sulfate
製品番号:
HY-17367A
数量:
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