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Results for "

20S proteasome

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Proteasome (66) Akt (2) Antibiotic (2) Apoptosis (20) Autophagy (15) Bacterial (7) Biochemical Assay Reagents (2) Caspase (1) Cathepsin (1) Ceramidase (1) Deubiquitinase (1) E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (3) Fungal (2) IAP (1) Interleukin Related (2) Isotope-Labeled Compounds (3) Keap1-Nrf2 (2) Ligands for Target Protein for PROTAC (2) Microtubule/Tubulin (1) Mitophagy (3) MMP (5) NF-κB (9) Nuclear Hormone Receptor 4A/NR4A (1) Oct3/4 (1) Parasite (5) PARP (1) Phosphatase (1) PROTACs (2) Reference Standards (7) SOD (2) TGF-beta/Smad (2) TREM receptor (4) β-catenin (1)
By Research Areas:	Cancer (53) Cardiovascular Disease (2) Infection (13) Inflammation/Immunology (15) Metabolic Disease (3) Neurological Disease (12)

By Targets:

Proteasome (66)

Akt (2)

Antibiotic (2)

Apoptosis (20)

Autophagy (15)

Bacterial (7)

Biochemical Assay Reagents (2)

Caspase (1)

Cathepsin (1)

Ceramidase (1)

Deubiquitinase (1)

E1/E2/E3 Enzyme (1)

E3 Ligase Ligand-Linker Conjugates (1)

Endogenous Metabolite (3)

Fungal (2)

IAP (1)

Interleukin Related (2)

Isotope-Labeled Compounds (3)

Keap1-Nrf2 (2)

Ligands for Target Protein for PROTAC (2)

Microtubule/Tubulin (1)

Mitophagy (3)

MMP (5)

NF-κB (9)

Nuclear Hormone Receptor 4A/NR4A (1)

Oct3/4 (1)

Parasite (5)

PARP (1)

Phosphatase (1)

PROTACs (2)

Reference Standards (7)

SOD (2)

TGF-beta/Smad (2)

TREM receptor (4)

β-catenin (1)

By Research Areas:

Cancer (53)

Cardiovascular Disease (2)

Infection (13)

Inflammation/Immunology (15)

Metabolic Disease (3)

Neurological Disease (12)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

GMP Molecules

Targets Recommended: Proteasome Proteasome Cap Targeting Chimeras

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-10227

Bortezomib Maximum Cited Publications 261 Publications Verification PS-341; LDP-341; NSC 681239	Proteasome NF-κB Apoptosis Autophagy TREM receptor Ligands for Target Protein for PROTAC	Cancer
Bortezomib (PS-341) is a reversible and selective *proteasome* inhibitor, and potently inhibits **20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB*. Bortezomib is the first proteasome* inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .

HY-10453

Ixazomib 20+ Cited Publications MLN2238	Proteasome Autophagy	Cancer
Ixazomib (MLN2238) is a selective, potent, and reversible *proteasome* inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC₅₀ of 3.4 nM (K_i of 0.93 nM).

HY-N2117

Isoginkgetin 15+ Cited Publications	MMP Akt NF-κB Proteasome Apoptosis Autophagy	Inflammation/Immunology Cancer
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the **20S proteasome, induces apoptosis and activates autophagy** .

HY-13067

Celastrol Maximum Cited Publications 61 Publications Verification Tripterine; Tripterin	Proteasome Autophagy Mitophagy Apoptosis Endogenous Metabolite Antibiotic Bacterial Nuclear Hormone Receptor 4A/NR4A	Infection Inflammation/Immunology Cancer
Celastrol (Tripterine;Tripterin) is a *proteasome* inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified **20S proteasome with IC₅₀ of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus** (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .

HY-16594

Lactacystin 5+ Cited Publications	Proteasome Cathepsin Apoptosis	Cardiovascular Disease Infection Neurological Disease Cancer
Lactacystin is a potent, orally active, irreversible, cell-permeable, selective 20S *proteasome* inhibitor (IC₅₀ = 4.8 μM). Lactacystin also inhibits the lysosomal enzyme cathepsin A. Lactacystin inhibits cell growth and induces apoptosisand cell cycle arrest, and has antiviral and antioxidative activity. Lactacystin induces neurite outgrowth and hypertension. Lactacystin has the potential for the research of cancer, Neurological Disease, hypertension and Malaria, and so on ^[2] ^[6] .

HY-N2166

Tomatine 2 Publications Verification α-Tomatine; Lycopersicin; Tomatin	Proteasome Apoptosis	Neurological Disease
Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits **20S proteasome** activity .

HY-153034

LONP1-IN-2 3 Publications Verification	Proteasome Phosphatase	Cancer
LONP1-IN-2 (Compound 9e) is a potent and selective LONP1 inhibitor with an IC₅₀ value of 0.093 μM. LONP1-IN-2 can be used in research of cancer .

HY-10985

Marizomib 15+ Cited Publications Salinosporamide A; NPI-0052	Proteasome	Cancer
Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, *pan-proteasome* inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC₅₀=3.5, 28, and 430 nM, respectively) .

HY-120722

TCH-165 2 Publications Verification	Proteasome	Cancer
TCH-165 is a small molecule modulator of proteasome assembly, which increases *20S* levels and facilitates *20S*-mediated protein degradation .

HY-123053

Z-Leu-Leu-Glu-AMC 3 Publications Verification Z-LLE-AMC	Proteasome	Neurological Disease
Z-Leu-Leu-Glu-AMC (Z-LLE-AMC) is a peptide-AMC linked substrate used to measure the postacidic-like hydrolysing activity of *proteasome*. Z-Leu-Leu-Glu-AMC can be used for the research of parkinson's disease .

HY-150602

20S Proteasome activator 1	Proteasome	Neurological Disease
20S Proteasome activator 1 is a potent **20S proteasome activator with EC₂₀₀** values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20S Proteasome activator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant of α-synuclein. 20S Proteasome activator 1 can be used for researching neurodegenerative diseases .

HY-108552

MG-115 1 Publications Verification	Proteasome Apoptosis	Cancer
MG-115 is a potent and reversible *proteasome* inhibitor, with K_is of 21 nM and 35 nM for *20S* and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis .

HY-W017227

Alloxan hydrate 1 Publications Verification	Proteasome	Metabolic Disease Cancer
Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a *proteasome* inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas .

HY-108549

clasto-Lactacystin β-lactone Omuralide; β-Clastolactacystin	Proteasome	Cancer
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible **20S proteasome** inhibitor.

HY-115391

Boc-LRR-AMC 1 Publications Verification Boc-Leu-Arg-Arg-AMC	Biochemical Assay Reagents	Others
Boc-LRR-AMC (Boc-Leu-Arg-Arg-AMC) is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .

HY-N6013

Aloin (mixture of A&B)	MMP Proteasome Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Bacterial Fungal	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S *proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3* pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .

HY-123051

Ac-WLA-AMC	Proteasome	Inflammation/Immunology
Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate .

HY-10227R

Bortezomib (Standard) PS-341 (Standard); LDP-341 (Standard); NSC 681239 (Standard)	Reference Standards Proteasome NF-κB Apoptosis Autophagy TREM receptor	Cancer
Bortezomib (Standard) is the analytical standard of Bortezomib. This product is intended for research and analytical applications. Bortezomib (PS-341) is a reversible and selective *proteasome* inhibitor, and potently inhibits **20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB*. Bortezomib is the first proteasome* inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .

HY-136528

RA-9	Deubiquitinase Apoptosis	Cancer
RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells .

HY-W001023

5-Amino-8-hydroxyquinoline 5A8HQ; 5AHQ	Proteasome NF-κB	Cancer
5-Amino-8-hydroxyquinoline (5A8HQ; 5AHQ) is an orally active non-competitive **20S proteasome inhibitor. 5-Amino-8-hydroxyquinoline can inhibit NF-κB** activity and induce cancer cells death and shows low cytotoxicity towards normal hematopoietic cells. 5-Amino-8-hydroxyquinoline can be used for the research of cancer, such as leukemia .

HY-123052

Ac-PAL-AMC	Proteasome	Inflammation/Immunology
Ac-PAL-AMC is a fluorogenic substrate specific for 20S proteasome LMP2/β1i activity .

HY-13067R

Celastrol (Standard) Tripterine (Standard); Tripterin (Standard)	Reference Standards Proteasome Autophagy Mitophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Celastrol (Standard) is the analytical standard of Celastrol. This product is intended for research and analytical applications. Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC₅₀ of 2.5 μM.

HY-129867

Z-Leu-Leu-Leu-AMC Z-LLL-AMC	Proteasome	Others
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the **20S proteasome** .

HY-107412

Proteasome inhibitor IX PS-IX; AM114	Proteasome	Cancer
Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC₅₀ value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53 ^+/+ cells growth inhibitory activity with an IC₅₀ value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity .

HY-23020

Boc3Arg	Proteasome	Cancer
Boc3Arg is the tert-butyl carbamate-protected arginine. Boc3Arg is an efficient tag to induce degradation through directly localizing the protein to the 20S proteasome .

HY-10227S

Bortezomib-d8 PS-341-d₈; LDP-341-d₈; NSC 681239-d₈	Isotope-Labeled Compounds Proteasome NF-κB Apoptosis Autophagy TREM receptor	Cancer
Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective *proteasome* inhibitor, and potently inhibits **20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB*. Bortezomib is the first proteasome* inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .

HY-P2483B

Octaarginine acetate	Bacterial Proteasome	Infection Inflammation/Immunology Cancer
Octaarginine acetate is a cell-penetrating peptide and *proteasome* inhibitor. Octaarginine acetate exhibits mixed-type inhibition against **20S proteasome** chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine acetate induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine acetate can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-P2483

Octaarginine	Proteasome Bacterial	Infection Inflammation/Immunology Cancer
Octaarginine is a cell-penetrating peptide and *proteasome* inhibitor. Octaarginine exhibits mixed-type inhibition against **20S proteasome** chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-150226

Enzyme-IN-1	Proteasome	Inflammation/Immunology
Enzyme-IN-1 (compound 1) is a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases. Specifically, Enzyme-IN-1 inhibits the chymotrypsin-like activity (CT-L) of the **20S proteasome**. Enzyme-IN-1 may has potential antiinflammatory properties .

HY-150591

20S Proteasome-IN-3	Proteasome	Cancer
20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC₅₀=1.64 μM) . 20S Proteasome-IN-3 shows anti-tumor proliferation activity .

HY-151195

20S Proteasome-IN-4	Proteasome Parasite	Infection
20S Proteasome-IN-4 (Compound 7) is a brain-penetrant, parasite-selective, orally active **20S proteasome inhibitor with an IC₅₀** of 6.3 nM against T. b. brucei 20S proteasome. 20S Proteasome-IN-4 can be used for the research of human African trypanosomiasis (HAT) .

HY-150590

20S Proteasome-IN-2	Proteasome	Cancer
20S Proteasome-IN-2 is a human **20S proteasome** inhibitor. 20S Proteasome-IN-2 shows high selectivity to its β5 subunit with the IC₅₀ of 0.18 μM. 20S Proteasome-IN-2 displays anti-proliferative effect in vitro and in vivo, and arrests cell cycle at G2/M .

HY-137286

Z-Leu-Leu-Glu-βNA Z-Leu-Leu-Glu-β-naphthylamide	Proteasome	Others
Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) is a substrate for determination of the glutamylpeptidyl-peptide hydrolase activity of the 20S proteasome .

HY-158150

20S Proteasome-IN-5	Proteasome	Cancer
20S Proteasome-IN-5 (Compound 5) is a macrocyclic inhibitor of the **20S Proteasome, with IC₅₀** values of 0.19 and 52.5 μM for ChT-L and PGPH-L activity, respectively .

HY-139331

20S Proteasome-IN-1	Proteasome	Neurological Disease Inflammation/Immunology Cancer
20S Proteasome-IN-1 is a 26S proteasome inhibitor extracted from patent WO2006128196A2 compound 2. 20S Proteasome-IN-1 has the potential for cancer, immune-related disorders, inflammation, ischemic conditions, neurodegenerative disorders and other diseases research .

HY-169135

*PROTAC 20S* proteasome subunit β5 degrader 2**	PROTACs Proteasome	Cancer
PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader for 20S proteasome subunit β5, with a DC₅₀ of 0.16 μM. PROTAC 20S proteasome subunit β5 degrader 2 inhibits the proliferation of cancer cell FaDu with IC₅₀ of 0.23 μM. PROTAC 20S proteasome subunit β5 degrader 2 exhibits antitumor efficacy in mice models .

HY-169134

*PROTAC 20S* proteasome subunit β5 degrader 1**	PROTACs Apoptosis	Cancer
PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) is a targeted degrader of PROTAC for 20S proteasome subunit β5, with a DC₅₀ value of 0.11 μM in FaDu cells. PROTAC 20S proteasome subunit β5 degrader 1 disrupts the cell cycle, promotes apoptosis, and inhibits cell proliferation and migration in both FaDu and KM3/BTZ cells. PROTAC 20S proteasome subunit β5 degrader 1 can be used to study the resistance of pharyngeal cancer and multiple myeloma to Bortezomib (HY-10227) .

HY-W054146

RAMB4 1 Publications Verification	Proteasome	Cancer
RAMB4 is a *ubiquitin-proteasome* system (UPS)-stressor*. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S* proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity .

HY-169144

Bortezomib analog	Proteasome	Cancer
Bortezomib analog (Compound 13), an analog of Bortezomib (HY-10227), is an active control of 20S proteasome subunit β5 ligand.

HY-N2166R

Tomatine (Standard) α-Tomatine (Standard); Lycopersicin (Standard); Tomatin (Standard)	Reference Standards Proteasome Apoptosis	Neurological Disease
Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity .

HY-10227G

Bortezomib PS-341; LDP-341; NSC 681239	Proteasome NF-κB Apoptosis Autophagy TREM receptor	Cancer
Bortezomib (GMP) (PS-341 (GMP)) is Bortezomib (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Bortezomib (PS-341) is a reversible and selective *proteasome* inhibitor, and potently inhibits **20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB*. Bortezomib is the first proteasome* inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .

HY-137897

Bz-VGR-AMC	Proteasome	Others
Bz-VGR-AMC is a substrate for the trypsin-like activity of the **20S proteasome*. Bz-VGR-AMC can be used to measure the trypsin-like (β2) activity of the 20S* proteasome .

HY-W048404

Bortezomib impurity A	Proteasome	Cancer
Bortezomib impurity A is a metabolite of the 20S proteasome inhibitor Bortezomib (HY-10227).

HY-161079

TDI-8304	Parasite	Infection
TDI-8304, a macrocyclic peptide, is a potent, species selective, and noncovalent **Plasmodium falciparum (Pf20S)** inhibitor. TDI-8304 shows highly selective for Pf20S over human proteasomes .

HY-10453R

Ixazomib (Standard) MLN2238 (Standard)	Reference Standards Proteasome Autophagy	Cancer
Ixazomib (Standard) is the analytical standard of Ixazomib. This product is intended for research and analytical applications. Ixazomib (MLN2238) is a selective, potent, and reversible *proteasome* inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC₅₀ of 3.4 nM (K_i of 0.93 nM).

HY-149514

BC-05	Proteasome	Cancer
BC-05 is an orally active and potent inhibitor of CD13 and *proteasome. BC-05 has an IC₅₀* value of 0.13 μM for human CD13 and an IC₅₀ value of 1.39 μM for the 20S proteasome. BC-05 can be used in multiple myeloma research .

HY-N15130

Cerpegin	Proteasome	Inflammation/Immunology
Cerpegin, a pyridinone-fused c-lactone, is an inhibitor of 20S proteasome. Cerpegin can be used as a tranquillizer, anti-inflammatory, analgesic and antiulcer .

HY-N2117R

Isoginkgetin (Standard)	Reference Standards MMP Akt NF-κB Proteasome Apoptosis Autophagy	Inflammation/Immunology Cancer
Isoginkgetin (Standard) is the analytical standard of Isoginkgetin. This product is intended for research and analytical applications. Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy .

HY-13067G

Celastrol Tripterine; Tripterin	Endogenous Metabolite Proteasome Antibiotic Apoptosis Bacterial Autophagy Mitophagy	Infection Inflammation/Immunology Cancer
Celastrol (GMP) (Tripterine (GMP)) is Celastrol (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Celastrol (Tripterine;Tripterin) is a *proteasome* inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified **20S proteasome with IC₅₀ of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus** (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .

HY-171956

Carmaphycin-17	Proteasome Parasite	Infection
Carmaphycin-17 (CP-17) is a selective 20S proteasome inhibitor with an EC₅₀ of 217 ?nM. Carmaphycin-17 has potent antimicrobial activity against Trichomonas vaginalis. Carmaphycin-17 overcomes Metronidazole (HY-B0318) resistance and significantly reduces parasite burden upon topical treatment without any apparent adverse effects in vaginal trichomonad infection mice model. Carmaphycin-17 can be used for sexually transmitted disease like trichomoniasis research .

Cat. No.	상품명	Type

HY-123051

Ac-WLA-AMC	Fluorescent Dyes
Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate .

HY-10227G

Bortezomib

PS-341; LDP-341; NSC 681239

Fluorescent Dyes

Bortezomib (GMP) (PS-341 (GMP)) is Bortezomib (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .

HY-13067G

Celastrol

Tripterine; Tripterin

Fluorescent Dyes

Celastrol (GMP) (Tripterine (GMP)) is Celastrol (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC₅₀ of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .

Cat. No.	상품명	Type

HY-10227G

Bortezomib

PS-341; LDP-341; NSC 681239

Biochemical Assay Reagents

HY-13067G

Celastrol

Tripterine; Tripterin

Biochemical Assay Reagents

Cat. No.	상품명	Target	Research Area

HY-123053

Z-Leu-Leu-Glu-AMC 3 Publications Verification Z-LLE-AMC	Proteasome	Neurological Disease
Z-Leu-Leu-Glu-AMC (Z-LLE-AMC) is a peptide-AMC linked substrate used to measure the postacidic-like hydrolysing activity of *proteasome*. Z-Leu-Leu-Glu-AMC can be used for the research of parkinson's disease .

HY-115391

Boc-LRR-AMC 1 Publications Verification Boc-Leu-Arg-Arg-AMC	Biochemical Assay Reagents	Others
Boc-LRR-AMC (Boc-Leu-Arg-Arg-AMC) is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .

HY-123051

Ac-WLA-AMC	Proteasome	Inflammation/Immunology
Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate .

HY-129867

Z-Leu-Leu-Leu-AMC Z-LLL-AMC	Proteasome	Others
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the **20S proteasome** .

HY-P2483B

Octaarginine acetate	Bacterial Proteasome	Infection Inflammation/Immunology Cancer
Octaarginine acetate is a cell-penetrating peptide and *proteasome* inhibitor. Octaarginine acetate exhibits mixed-type inhibition against **20S proteasome** chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine acetate induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine acetate can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-P2483

Octaarginine	Proteasome Bacterial	Infection Inflammation/Immunology Cancer
Octaarginine is a cell-penetrating peptide and *proteasome* inhibitor. Octaarginine exhibits mixed-type inhibition against **20S proteasome** chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-137286

Z-Leu-Leu-Glu-βNA Z-Leu-Leu-Glu-β-naphthylamide	Proteasome	Others
Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) is a substrate for determination of the glutamylpeptidyl-peptide hydrolase activity of the 20S proteasome .

HY-158150

20S Proteasome-IN-5	Proteasome	Cancer
20S Proteasome-IN-5 (Compound 5) is a macrocyclic inhibitor of the **20S Proteasome, with IC₅₀** values of 0.19 and 52.5 μM for ChT-L and PGPH-L activity, respectively .

HY-137897

Bz-VGR-AMC	Proteasome	Others
Bz-VGR-AMC is a substrate for the trypsin-like activity of the **20S proteasome*. Bz-VGR-AMC can be used to measure the trypsin-like (β2) activity of the 20S* proteasome .

HY-W753820A

Boc-LRR-AMC TFA Boc-Leu-Arg-Arg-AMC TFA	Biochemical Assay Reagents	Others
Boc-LRR-AMC TFA (Boc-Leu-Arg-Arg-AMC TFA) is the TFA salt form of Boc-LRR-AMC (HY-115391). Boc-LRR-AMC TFA is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .

HY-P2483A

Octaarginine TFA	Proteasome Bacterial	Infection Neurological Disease Cancer
Octaarginine TFA is a cell-penetrating peptide and *proteasome* inhibitor. Octaarginine TFA exhibits mixed-type inhibition against **20S proteasome** chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine TFA induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine TFA can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-N2117

Isoginkgetin 15+ Cited Publications	Flavonoids Classification of Application Fields Ginkgoaceae Phenols Polyphenols Plants Disease Research Fields Ginkgo biloba Biflavones Source Classification Cancer	MMP Akt NF-κB Proteasome Apoptosis Autophagy
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the **20S proteasome, induces apoptosis and activates autophagy** .

HY-13067

Celastrol Maximum Cited Publications 61 Publications Verification Tripterine; Tripterin	Structural Classification Triterpenes Classification of Application Fields Anti-aging Terpenoids Celastraceae Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology Source Classification Cancer	Proteasome Autophagy Mitophagy Apoptosis Endogenous Metabolite Antibiotic Bacterial Nuclear Hormone Receptor 4A/NR4A
Celastrol (Tripterine;Tripterin) is a *proteasome* inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified **20S proteasome with IC₅₀ of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus** (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .

HY-16594

Lactacystin 5+ Cited Publications	Structural Classification Microorganisms Antibiotics Other Antibiotics Source Classification	Proteasome Cathepsin Apoptosis
Lactacystin is a potent, orally active, irreversible, cell-permeable, selective 20S *proteasome* inhibitor (IC₅₀ = 4.8 μM). Lactacystin also inhibits the lysosomal enzyme cathepsin A. Lactacystin inhibits cell growth and induces apoptosisand cell cycle arrest, and has antiviral and antioxidative activity. Lactacystin induces neurite outgrowth and hypertension. Lactacystin has the potential for the research of cancer, Neurological Disease, hypertension and Malaria, and so on ^[2] ^[6] .

HY-N2166

Tomatine 2 Publications Verification α-Tomatine; Lycopersicin; Tomatin	Solanum lycopersicum L. Plants Solanaceae Source Classification Steroids	Proteasome Apoptosis
Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits **20S proteasome** activity .

HY-10985

Marizomib 15+ Cited Publications Salinosporamide A; NPI-0052	Marine natural products Marine microorganism Source Classification	Proteasome
Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, *pan-proteasome* inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC₅₀=3.5, 28, and 430 nM, respectively) .

HY-108549

clasto-Lactacystin β-lactone Omuralide; β-Clastolactacystin	Classification of Application Fields Disease Research Fields Cancer	Proteasome
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible **20S proteasome** inhibitor.

HY-N6013

Aloin (mixture of A&B)	Infection Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Aloe vera (L.) Burm. f. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Source Classification	MMP Proteasome Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Bacterial Fungal
Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S *proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3* pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .

HY-13067R

Celastrol (Standard) Tripterine (Standard); Tripterin (Standard)	Structural Classification Triterpenes Terpenoids Celastraceae Plants Tripterygium wilfordii Hook. f. Source Classification	Reference Standards Proteasome Autophagy Mitophagy Apoptosis Endogenous Metabolite
Celastrol (Standard) is the analytical standard of Celastrol. This product is intended for research and analytical applications. Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC₅₀ of 2.5 μM.

HY-N2166R

Tomatine (Standard) α-Tomatine (Standard); Lycopersicin (Standard); Tomatin (Standard)	Structural Classification Solanum lycopersicum L. Plants Solanaceae Source Classification Steroids	Reference Standards Proteasome Apoptosis
Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity .

HY-N15130

Cerpegin	Apocynaceae Ceropegia junceaRoxb. Alkaloids Pyridine Alkaloids Plants Source Classification	Proteasome
Cerpegin, a pyridinone-fused c-lactone, is an inhibitor of 20S proteasome. Cerpegin can be used as a tranquillizer, anti-inflammatory, analgesic and antiulcer .

HY-N2117R

Isoginkgetin (Standard)	Structural Classification Flavonoids Ginkgoaceae Phenols Polyphenols Plants Ginkgo biloba Biflavones Source Classification	Reference Standards MMP Akt NF-κB Proteasome Apoptosis Autophagy
Isoginkgetin (Standard) is the analytical standard of Isoginkgetin. This product is intended for research and analytical applications. Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy .

HY-N6013R

Aloin (mixture of A&B) (Standard)	Structural Classification Liliaceae Ketones, Aldehydes, Acids Aloe vera (L.) Burm. f. Phenols Polyphenols Plants Source Classification	Reference Standards Proteasome MMP Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Fungal Bacterial
Aloin (mixture of A&B) (Standard) is the analytical standard of Aloin (mixture of A&B) (HY-N6013). This product is intended for research and analytical applications. Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S *proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3* pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .

Cat. No.	상품명	Chemical Structure

HY-10227S

Bortezomib-d8

Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .

HY-W748328

Ixazomib-13C2,15N
Ixazomib- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Ixazomib. Ixazomib (MLN2238) is a selective, potent, and reversible *proteasome* inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC₅₀ of 3.4 nM (K_i of 0.93 nM) .

HY-10453S

Ixazomib-d7
Ixazomib-d₇ is the deuterium labeled Ixazomib (HY-10453). Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC₅₀ of 3.4 nM (K_i of 0.93 nM) .

Host:	Mouse (5) Rabbit (8)
Reactivity:	Human (12) Rat (12) Mouse (10) Monkey (2) Dog (2) human (1)
Application:	IHC-P (8) ICC/IF (12) IF-Tissue (1) IP (2) IHC-F (5) WB (11) FC (4)
Isotype:	IgG (9) IgG1 (4)
Conjugation:	Non-conjugated (13)
Clonality:	Monoclonal (8) Recombinant (6)
Modification:	Unmodified (9)

Cat. No.	Compare	상품명	Application	Reactivity	Image

HY-P80437

	Proteasome 20S LMP7 Antibody (YA121)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Proteasome 20S LMP7 Antibody (YA121) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Proteasome 20S LMP7.

HY-P82556

	Proteasome 20S C2/HC2 Antibody (YA2301) NU; HC2; PROS30; psmA1; PSC2; proteasome 20S C2	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	Proteasome 20S C2/HC2 Antibody (YA2301) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Proteasome 20S C2/HC2.

HY-P88393

	*PSMB7 (Proteasome* 20S beta 7 ) Antibody (YA8077)** Z	ICC/IF	Human, Dog, Rat, Monkey, Mouse
	PSMB7 (Proteasome 20S beta 7 ) Antibody (YA8077) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PSMB7 (Proteasome 20S beta 7 ).

HY-P88393A

	*PSMB7 (Proteasome* 20S beta 7 ) Antibody (YA8077)(PBS only)** Z	ICC/IF	Human, Dog, Rat, Monkey, Mouse
	PSMB7 (Proteasome 20S beta 7 ) Antibody (YA8077) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PSMB7 (Proteasome 20S beta 7 ).

HY-P81999

	Proteasome 20S alpha 2/HC3 Antibody (YA1744) HC3; PMSA2; proteasome component C3; PSC2; PSC3; psmA2	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Proteasome 20S alpha 2/HC3 Antibody (YA1744) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Proteasome 20S alpha 2/HC3.

HY-P82639

	Proteasome 20S alpha 2/HC3 Antibody (YA2384) HC3; PMSA2; proteasome component C3; PSC2; PSC3; psmA2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Proteasome 20S alpha 2/HC3 Antibody (YA2384) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Proteasome 20S alpha 2/HC3.

HY-P81999A

	Proteasome 20S alpha 2/HC3 Antibody (YA1744)(PBS only) HC3; PMSA2; proteasome component C3; PSC2; PSC3; psmA2	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Proteasome 20S alpha 2/HC3 Antibody (YA1744) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Proteasome 20S alpha 2/HC3.

HY-P89742

	20S Proteasome α8 Antibody (YA9086) Alpha4s, proteasome alpha 4 subunit, proteasome subunit alpha-type 7-like, proteasome subunit alpha-type 8, PSMA7L	WB, IP	human
	20S Proteasome α8 Antibody (YA9086) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to 20S Proteasome α8.

HY-P82002

	Proteasome 20S LMP2 Antibody (YA1747) Beta1i; LMP2; PSMB 9; PSMB6i; PSMB9; RING12	WB, ICC/IF	Human, Mouse, Rat
	Proteasome 20S LMP2 Antibody (YA1747) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Proteasome 20S LMP2.

HY-P82002A

	Proteasome 20S LMP2 Antibody (YA1747)(PBS only) Beta1i; LMP2; PSMB 9; PSMB6i; PSMB9; RING12	WB, ICC/IF	Human, Mouse, Rat
	Proteasome 20S LMP2 Antibody (YA1747) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Proteasome 20S LMP2.

HY-P80876

	Proteasome 20S LMP7 Antibody (YA684) PSMB8; LMP7; PSMB5i; RING10; Y2; proteasome subunit beta type-8; Low molecular mass protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; proteasome component C13; proteasome subunit beta-5i; Really interesting	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	Proteasome 20S LMP7 Antibody (YA684) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Proteasome 20S LMP7.

HY-P85261

	Proteasome 20S LMP7 Antibody (YA4953) PSMB8; LMP7; PSMB5i; RING10; Y2; proteasome subunit beta type-8; Low molecular mass protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; proteasome component C13; proteasome subunit beta-5i; Really interesting	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, FC	Human, Mouse, Rat
	Proteasome 20S LMP7 Antibody (YA4953) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Proteasome 20S LMP7.

HY-P80876A

	Proteasome 20S LMP7 Antibody (YA684)(PBS only) PSMB8; LMP7; PSMB5i; RING10; Y2; proteasome subunit beta type-8; Low molecular mass protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; proteasome component C13; proteasome subunit beta-5i; Really interesting	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	Proteasome 20S LMP7 Antibody (YA684) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Proteasome 20S LMP7.

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Targets Recommended: Proteasome Proteasome Cap Targeting Chimeras

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-13067G

Celastrol Tripterine; Tripterin	Endogenous Metabolite Proteasome Antibiotic Apoptosis Bacterial Autophagy Mitophagy	Infection Inflammation/Immunology Cancer
Celastrol (GMP) (Tripterine (GMP)) is Celastrol (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Celastrol (Tripterine;Tripterin) is a *proteasome* inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified **20S proteasome with IC₅₀ of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus** (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .

HY-10227G

Bortezomib PS-341; LDP-341; NSC 681239	Proteasome NF-κB Apoptosis Autophagy TREM receptor	Cancer
Bortezomib (GMP) (PS-341 (GMP)) is Bortezomib (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Bortezomib (PS-341) is a reversible and selective *proteasome* inhibitor, and potently inhibits **20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB*. Bortezomib is the first proteasome* inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .

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