1. Metabolic Enzyme/Protease
  2. Proteasome
  3. TCH-165

TCH-165 

Cat. No.: HY-120722
Handling Instructions

TCH-165 is a small molecule modulator of proteasome assembly, which increases 20S levels and facilitates 20S-mediated protein degradation.

For research use only. We do not sell to patients.

TCH-165 Chemical Structure

TCH-165 Chemical Structure

CAS No. : 1446350-60-2

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Description

TCH-165 is a small molecule modulator of proteasome assembly, which increases 20S levels and facilitates 20S-mediated protein degradation[1].

IC50 & Target

Proteasome assembly[1]

In Vitro

TCH-165 (0-10 μM; 24 hours; HEK293T cells) treatment enhances ODC degradation is blocked by BTZ indicated that this event is proteasome-mediated. TCH-165 enhances proteolytic degradation in a concentration-dependent manner[1].
TCH-165 enhances the chymotrypsin-like (CT-L), trypsin-like (Tryp-L) and caspase-like (Casp-L) activities with EC50s of 4.2 μM, 3.2 μM and 4.7 μM, respectively[1].
TCH-165 enhances 20S-mediated degradation of IDPs, α-syn, and tau in vitro, and does not induce the degradation of structured proteins such as GAPDH[1].
TCH-165-treated cells display a decrease in the assembled 26S and an increase in the 20S proteasome[1].

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 0 μM, 3 μM, 10 μM
Incubation Time: 24 hours
Result: Enhanced proteolytic degradation in a concentration-dependent manner.
Molecular Weight

595.73

Formula

C₃₉H₃₇N₃O₃

CAS No.

1446350-60-2

SMILES

O=C([[email protected]]1(C2=CC=CC=C2)N=C(C3=CC=C(OC)C=C3)N(CC4=CC=CC=C4)[[email protected]@H]1C5=CC=C(NCC6=CC=CC=C6)C=C5)OCC

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TCH-165TCH165TCH 165ProteasomeIDPsα-syntauproteasomeassemblydegradation20Schymotrypsin-liketrypsin-likecaspase-likeInhibitorinhibitorinhibit

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TCH-165
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HY-120722
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