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Cat. No.: HY-183009

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Pf20S-IN-1

Pf20S-IN-1 is a selective inhibitor of the 20S proteasome β5 subunit of Plasmodium falciparum. Pf20S-IN-1 exhibits antiparasitic activity against Plasmodium falciparum, with an EC₅₀ of 20.1 nM against the Plasmodium falciparum W2 strain. Pf20S-IN-1 shows weak inhibitory effect on human 20S proteasome, has no obvious toxicity to human foreskin fibroblasts (HFF), and has a selectivity index > 25000. Pf20S-IN-1 can be used in malaria research.

For research use only. We do not sell to patients.

Formula: C₃₃H₄₂FN₅O₆
Molecular Weight:623.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pf20S-IN-1 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Plasmodium

All Parasite Isoforms :

In Vitro

Pf20S-IN-1 (compound C-5) (1 nM-10 μM; 72 h) potently inhibits Plasmodium falciparum W2 cell growth with an EC₅₀ of 20.1 nM and exhibits a selectivity index > 25,000 relative to human foreskin fibroblasts^[1].
Pf20S-IN-1 (30 min preincubation, 3 h kinetic assays) potently and selectively inhibits the β5 subunit of purified Plasmodium falciparum 20S proteasome, exhibiting a 45-fold selectivity over the human constitutive 20S proteasome β5 subunit^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 623.71
Formula C₃₃H₄₂FN₅O₆
SMILES

COC([C@H](C(C)C)NC(N[C@@H](C(N[C@H]1CCCCNC(/C=C/[C@@H](NC1=O)CC2=CC=CC(F)=C2)=O)=O)CC3=CC=CC=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gu X, et al. An Optimized Route to the Syringolin Natural Products Enables Combinatorial Synthesis of Selective, Bioactive Inhibitors of the Plasmodium falciparum 20S Proteasome. J Med Chem. 2026;69(8):8897-8914.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Pf20S-IN-1

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Pf20S-IN-1 Related Classifications

HY-183009 Related Classifications