Pf20S-IN-1
Pf20S-IN-1 is a selective inhibitor of the 20S proteasome β5 subunit of Plasmodium falciparum. Pf20S-IN-1 exhibits antiparasitic activity against Plasmodium falciparum, with an EC50 of 20.1 nM against the Plasmodium falciparum W2 strain. Pf20S-IN-1 shows weak inhibitory effect on human 20S proteasome, has no obvious toxicity to human foreskin fibroblasts (HFF), and has a selectivity index > 25000. Pf20S-IN-1 can be used in malaria research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C33H42FN5O6
- 分子量:623.71
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[1]|
Plasmodium |
体外実験
Pf20S-IN-1 (compound C-5) (1 nM-10 μM; 72 h) potently inhibits Plasmodium falciparum W2 cell growth with an EC50 of 20.1 nM and exhibits a selectivity index > 25,000 relative to human foreskin fibroblasts[1].
Pf20S-IN-1 (30 min preincubation, 3 h kinetic assays) potently and selectively inhibits the β5 subunit of purified Plasmodium falciparum 20S proteasome, exhibiting a 45-fold selectivity over the human constitutive 20S proteasome β5 subunit[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 623.71
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分子式 C33H42FN5O6
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SMILES
COC([C@H](C(C)C)NC(N[C@@H](C(N[C@H]1CCCCNC(/C=C/[C@@H](NC1=O)CC2=CC=CC(F)=C2)=O)=O)CC3=CC=CC=C3)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Pf20S-IN-1 関連分類
HY-183009 関連分類
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