Pf20S-IN-1 

Pf20S-IN-1 is a selective inhibitor of the 20S proteasome β5 subunit of Plasmodium falciparum. Pf20S-IN-1 exhibits antiparasitic activity against Plasmodium falciparum, with an EC₅₀ of 20.1 nM against the Plasmodium falciparum W2 strain. Pf20S-IN-1 shows weak inhibitory effect on human 20S proteasome, has no obvious toxicity to human foreskin fibroblasts (HFF), and has a selectivity index > 25000. Pf20S-IN-1 can be used in malaria research^[1].

Pf20S-IN-1 (compound C-5) (1 nM-10 μM; 72 h) potently inhibits Plasmodium falciparum W2 cell growth with an EC₅₀ of 20.1 nM and exhibits a selectivity index > 25,000 relative to human foreskin fibroblasts^[1].
Pf20S-IN-1 (30 min preincubation, 3 h kinetic assays) potently and selectively inhibits the β5 subunit of purified Plasmodium falciparum 20S proteasome, exhibiting a 45-fold selectivity over the human constitutive 20S proteasome β5 subunit^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

623.71

C₃₃H₄₂FN₅O₆

COC([C@H](C(C)C)NC(N[C@@H](C(N[C@H]1CCCCNC(/C=C/[C@@H](NC1=O)CC2=CC=CC(F)=C2)=O)=O)CC3=CC=CC=C3)=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gu X, et al. An Optimized Route to the Syringolin Natural Products Enables Combinatorial Synthesis of Selective, Bioactive Inhibitors of the Plasmodium falciparum 20S Proteasome. J Med Chem. 2026;69(8):8897-8914.