PSMB7 (Proteasome 20S beta 7 ) Antibody (YA8077)
(Synonyms: Z)PSMB7 (Proteasome 20S beta 7 ) Antibody (YA8077) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PSMB7 (Proteasome 20S beta 7 ).
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF
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Reactivity :
Human, Dog, Rat, Monkey, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|
| Dilution Ratio | 1:100-250 |
Product Details
PSMB7 (Proteasome 20S beta 7 ) Antibody (YA8077) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PSMB7 (Proteasome 20S beta 7 ).
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Dog, Rat, Monkey, Mouse
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Calculated Molecular Weight Predicted band size: 29.8 kDa
Human recombinant protein fragment corresponding to amino acids 58-277 of human PSMB7 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PSMB7 component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity
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Subcellular Localization
Cytoplasm,Nucleus
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Expression
Tissue_Specificity: Expressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues -
Isoforms & Post-Translational Modification
Q99436 has two isomers: Q99436-1: 29965 Da (predicted); Q99436-2: 15323 Da (predicted).
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Subunit
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits
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SwissProt ID
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Synonyms
Z
Documentation
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