5-Amino-8-hydroxyquinoline dihydrochloride
5-Amino-8-hydroxyquinoline (5A8HQ; 5AHQ) dihydrochloride is an orally active non-competitive 20S proteasome inhibitor. 5-Amino-8-hydroxyquinoline dihydrochloride can inhibit NF-κB activity and induce cancer cells death and shows low cytotoxicity towards normal hematopoietic cells. 5-Amino-8-hydroxyquinoline dihydrochloride can be used for the research of cancer, such as leukemia.
For research use only. We do not sell to patients.
- CAS No.: 21302-43-2
- Formula: C9H10Cl2N2O
- Molecular Weight:233.09
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 relative |
1400 nM
Compound: EOS102214
|
Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
|
10.6019/EOS300108 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 21302-43-2
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Molecular Weight 233.09
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Formula C9H10Cl2N2O
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SMILES
NC1=CC=C(O)C2=NC=CC=C21.Cl.Cl
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Synonyms
5A8HQ dihydrochloride; 5AHQ dihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)