2. Nitrochin

Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway.

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Nitrochin Chemical Structure

Nitrochin Chemical Structure

CAS No. : 56-57-5

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Nitrochin Related Antibodies

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Description

Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway[1][2].

Molecular Weight

190.16

Formula

C9H6N2O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=[N+](C1=C2C=CC=CC2=[N+]([O-])C=C1)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (262.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2587 mL 26.2936 mL 52.5873 mL
5 mM 1.0517 mL 5.2587 mL 10.5175 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.2587 mL 26.2936 mL 52.5873 mL 131.4682 mL
5 mM 1.0517 mL 5.2587 mL 10.5175 mL 26.2936 mL
10 mM 0.5259 mL 2.6294 mL 5.2587 mL 13.1468 mL
15 mM 0.3506 mL 1.7529 mL 3.5058 mL 8.7645 mL
20 mM 0.2629 mL 1.3147 mL 2.6294 mL 6.5734 mL
25 mM 0.2103 mL 1.0517 mL 2.1035 mL 5.2587 mL
30 mM 0.1753 mL 0.8765 mL 1.7529 mL 4.3823 mL
40 mM 0.1315 mL 0.6573 mL 1.3147 mL 3.2867 mL
50 mM 0.1052 mL 0.5259 mL 1.0517 mL 2.6294 mL
60 mM 0.0876 mL 0.4382 mL 0.8765 mL 2.1911 mL
80 mM 0.0657 mL 0.3287 mL 0.6573 mL 1.6434 mL
100 mM 0.0526 mL 0.2629 mL 0.5259 mL 1.3147 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nitrochin56-57-54-NQOInhibitorinhibitorinhibit

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