56-57-5
56-57-5
Chemical Structure
Nitrochin
Synonym(s): 4-NQO
- CAS No.: 56-57-5
- Formula:C9H6N2O3
- Molecular Weight:190.16
IUPAC Name: 4-nitroquinoline 1-oxide
InChIKey: YHQDZJICGQWFHK-UHFFFAOYSA-N
SMILES: O=[N+](C1=C2C=CC=CC2=[N+]([O-])C=C1)[O-]
Biological Activity: Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nitrochin | 99.92% | Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway. | ||||||||||||||||||||
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Nitrochin (Standard) | ≥98% | Nitrochin (Standard) is the analytical standard of Nitrochin. This product is intended for research and analytical applications. Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway. | ||||||||||||||||||||
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NNMTi | 99.82% | NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2 μM) and selectively binds to the NNMT substrate-binding site residues. NNMTi promotes myoblast differentiation in vitro and enhances fusion and regenerative capacity of muscle stem cells (muSCs) in aged mice. | ||||||||||||||||||||
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6-Nitroquinazoline | 6-Nitroquinazoline is an antimalarial agent. 6-Nitroquinazoline is also a substrate for human liver aldehyde oxidase. | |||||||||||||||||||||
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Quindoxin | Quindoxin is an antibacterial and growth promoter, commonly used in the livestock industry. Quindoxin exhibits clear dose-dependent mutagenic activity against Salmonella typhimurium TA98 and TA100 strains. Quindoxin can cause DNA damage and has potential genotoxicity and carcinogenic risks. | |||||||||||||||||||||
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4-Nitroindole | 99.43% | 4-Nitroindole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Nitroxoline (Standard) | 99.64% | Nitroxoline (Standard) is the analytical standard of Nitroxoline. This product is intended for research and analytical applications. Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research. | ||||||||||||||||||||
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6-Nitroindole | 6-Nitro-1H-indole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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7-Nitroindole | 99.52% | 7-Nitroindole is a cleavable base analog and Antibacterial agent. 7-Nitroindole inhibits the growth of Lactobacillus arabinosus. 7-Nitroindole is used in studies of light-controlled DNA cleavage and Lactobacillus arabinosus infection. | ||||||||||||||||||||
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KAT8-IN-1 | 99.61% | KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases. | ||||||||||||||||||||
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5-Nitroisoquinoline | 98.99% | 5-Nitroisoquinoline (5NIQ) has the molecular formula C9H6N2O2 and can be used as a molecular building block. | ||||||||||||||||||||
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7-Chloro-6-nitroquinoline | 97.0% | 7-Chloro-6-nitroquinoline is a drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
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References
- [1]. Mukherjee A, et al. Carcinogen 4-Nitroquinoline Oxide (4-NQO) Induces Oncostatin-M (OSM) in Esophageal Cells. In Vivo. 2023 Mar-Apr;37(2):506-518. [Content Brief]
- [2]. Han H, et al. 4-NQO induces apoptosis via p53-dependent mitochondrial signaling pathway. Toxicology. 2007 Feb 12;230(2-3):151-63. [Content Brief]
