1. Metabolic Enzyme/Protease
  2. Proteasome
  3. Tomatine

Tomatine (Synonyms: α-Tomatine; Lycopersicin; Tomatin)

Cat. No.: HY-N2166
Handling Instructions

Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity.

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Tomatine Chemical Structure

Tomatine Chemical Structure

CAS No. : 17406-45-0

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Description

Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity[1].

In Vitro

Tomatine inhibits gastric carcinoma cell line (AGS), neuroblastoma cell line (SH-SY5Y) and non-small cell lung cancer cell line (A549) with IC50s of 2 µM, 1.6 µM and 1.1 µM, respectively[1].

Molecular Weight

1034.19

Formula

C₅₀H₈₃NO₂₁

CAS No.

17406-45-0

SMILES

C[[email protected]@]12[[email protected]]([[email protected]@H]3C)([H])[[email protected]](O[[email protected]@]34CC[[email protected]](C)CN4)([H])C[[email protected]@]1([H])[[email protected]@](CC[[email protected]]5([H])[[email protected]@]6(CC[[email protected]](O[[email protected]]([[email protected]@H]([[email protected]@H](O)[[email protected]]7O[[email protected]@](O[[email protected]](CO)[[email protected]@H](O)[[email protected]@H]8O[[email protected]@](OC[[email protected]@H](O)[[email protected]@H]9O)([H])[[email protected]@H]9O)([H])[[email protected]@H]8O[[email protected]]([[email protected]@H]([[email protected]@H](O)[[email protected]@H]%10O)O)([H])O[[email protected]@H]%10CO)O)([H])O[[email protected]@H]7CO)C5)C)([H])[[email protected]]6([H])CC2

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Tomatine
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