2. Metabolic Enzyme/Protease Apoptosis
  3. Proteasome Apoptosis
  4. MG-115

MG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis.

For research use only. We do not sell to patients.

MG-115 Chemical Structure

MG-115 Chemical Structure

CAS No. : 133407-86-0

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1 mg USD 122 In-stock
5 mg USD 270 In-stock
10 mg USD 430 In-stock
50 mg USD 690 In-stock
100 mg USD 1100 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

MG-115 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE MG-115

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis[1][2][3].

IC50 & Target

Ki: 21 nM (20S proteasome); 35 nM (26 Sproteasome)[1]
In Vitro

MG-115 (0.1-10 μM; 24 h) dose-dependently decreases the viability of HepG2 cells[3].
MG-115 (0.1-10 μM; 24 h) amplifies the reporter gene expression mediated by CWK18 DNA condensates[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MG-115 Related Antibodies

Cell Viability Assay[3]

Cell Line: HepG2 cells
Concentration: 0.1, 1, 2, 5, 10 μM
Incubation Time: 24 hours
Result: Dose-dependently decreased cell viability.
Inhibited the proteasomal activity, with an IC50 of 2 μM.
Molecular Weight

461.59

Formula

C25H39N3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C=O)CCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (216.64 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1664 mL 10.8321 mL 21.6642 mL
5 mM 0.4333 mL 2.1664 mL 4.3328 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.69%

COA (245 KB) HNMR (121 KB) RP-HPLC (141 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1664 mL 10.8321 mL 21.6642 mL 54.1606 mL
5 mM 0.4333 mL 2.1664 mL 4.3328 mL 10.8321 mL
10 mM 0.2166 mL 1.0832 mL 2.1664 mL 5.4161 mL
15 mM 0.1444 mL 0.7221 mL 1.4443 mL 3.6107 mL
20 mM 0.1083 mL 0.5416 mL 1.0832 mL 2.7080 mL
25 mM 0.0867 mL 0.4333 mL 0.8666 mL 2.1664 mL
30 mM 0.0722 mL 0.3611 mL 0.7221 mL 1.8054 mL
40 mM 0.0542 mL 0.2708 mL 0.5416 mL 1.3540 mL
50 mM 0.0433 mL 0.2166 mL 0.4333 mL 1.0832 mL
60 mM 0.0361 mL 0.1805 mL 0.3611 mL 0.9027 mL
80 mM 0.0271 mL 0.1354 mL 0.2708 mL 0.6770 mL
100 mM 0.0217 mL 0.1083 mL 0.2166 mL 0.5416 mL
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MG-115 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MG-115133407-86-0MG115MG 115ProteasomeApoptosis20S26SapoptosisInhibitorinhibitorinhibit

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