1. Metabolic Enzyme/Protease
    Apoptosis
  2. Proteasome
    Apoptosis
  3. MG-115

MG-115 

Cat. No.: HY-108552
Handling Instructions

MG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis.

For research use only. We do not sell to patients.

MG-115 Chemical Structure

MG-115 Chemical Structure

CAS No. : 133407-86-0

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Description

MG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis[1][2][3].

IC50 & Target

Ki: 21 nM (20S proteasome); 35 nM (26 Sproteasome)[1]

In Vitro

MG-115 (0.1-10 μM; 24 h) dose-dependently decreases the viability of HepG2 cells[3].
MG-115 (0.1-10 μM; 24 h) amplifies the reporter gene expression mediated by CWK18 DNA condensates[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: HepG2 cells
Concentration: 0.1, 1, 2, 5, 10 μM
Incubation Time: 24 hours
Result: Dose-dependently decreased cell viability.
Inhibited the proteasomal activity, with an IC50 of 2 μM.
Molecular Weight

461.59

Formula

C₂₅H₃₉N₃O₅

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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MG-115
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HY-108552
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