133407-86-0
133407-86-0
Chemical Structure
MG-115
- CAS No.: 133407-86-0
- Formula:C25H39N3O5
- Molecular Weight:461.59
IUPAC Name: benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxopentan-2-yl)amino)pentan-2-yl)amino)-1-oxopentan-2-yl)carbamate
InChIKey: QEJRGURBLQWEOU-FKBYEOEOSA-N
SMILES: O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C=O)CCC)=O)=O
Biological Activity: MG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MG-115 | 99.61% | MG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.95
HY-120234Z-LLNle-CHO -
Similarity Score 0.91
HY-13259MG-132 -
Similarity Score 0.91
HY-13259C(R)-MG-132 -
Similarity Score 0.89
HY-187132SIB-1281 -
Similarity Score 0.84
HY-136736β-Secretase Inhibitor II -
Similarity Score 0.82
HY-100223Calpeptin -
Similarity Score 0.81
HY-P5975Z-Leu-Leu-Leu-fluoromethyl ketone -
Similarity Score 0.80
HY-119131AK 275 -
Similarity Score 0.79
HY-123255BSc2118 -
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References
- [1]. Rock KL, et, al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 1994 Sep 9;78(5):761-71. [Content Brief]
- [2]. Lopes UG, et, al. p53-dependent induction of apoptosis by proteasome inhibitors. J Biol Chem. 1997 May 16;272(20):12893-6. [Content Brief]
- [3]. Kim J, et, al. The proteasome metabolizes peptide-mediated nonviral gene delivery systems. Gene Ther. 2005 Nov;12(21):1581-90. [Content Brief]
