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Cat. No.: HY-136736

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β-Secretase Inhibitor II

β-Secretase Inhibitor II is a β-Secretase inhibitor. β-Secretase Inhibitor II is a simple tripeptide aldehyde (IC₅₀=700 nM for inhibition of total Aβ and IC₅₀=2.5 μM for Aβ_1–42). β-Secretase Inhibitor II can be used for the research of Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 263563-09-3
Formula: C₂₅H₃₉N₃O₅
Molecular Weight:461.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

β-Secretase Inhibitor II Chemical Structure

CAS No.: 263563-09-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

IC50: 700 nM (Aβ)^[1].
IC50: 2.5 μM (Aβ_1–42)^[1]

All Beta-secretase Isoforms :

BACE1
BACE2

In Vitro

β-Secretase Inhibitor II is a simple tripeptide aldehyde (IC₅₀=700 nM for inhibition of total Aβ and IC₅₀=2.5 μM for Aβ_1–42). β-Secretase Inhibitor II inhibits the formation of both total Aβ and Aβ_1–42 in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 263563-09-3
Molecular Weight 461.59
Formula C₂₅H₃₉N₃O₅
SMILES

O=C(N[C@H](C=O)CC(C)C)[C@H](CC(C)C)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Abbenante, G., et al. Inhibitors of β-Amyloid Formation Based on the β-Secretase Cleavage Site. Biochemical and Biophysical Research Communications. 2000; 268(1), 133–135.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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β-Secretase Inhibitor II

BCA

Tenuifolin

Eslicarbazepine

β-Secretase Inhibitor IV

Verubecestat TFA

(1α,1'S,4β)-Lanabecestat

Eslicarbazepine (Standard)

Tenuifolin (Standard)

β-Secretase Inhibitor IV (Standard)

LY2886721 hydrochloride

Deoxyneocryptotanshinone

(1α,1'S,4β)-Lanabecestat (Standard)

All Beta-secretase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

β-Secretase Inhibitor II

BCA

Tenuifolin

Eslicarbazepine

β-Secretase Inhibitor IV

Verubecestat TFA

(1α,1'S,4β)-Lanabecestat

Eslicarbazepine (Standard)

Tenuifolin (Standard)

β-Secretase Inhibitor IV (Standard)

LY2886721 hydrochloride

Deoxyneocryptotanshinone

(1α,1'S,4β)-Lanabecestat (Standard)

All Beta-secretase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

β-Secretase Inhibitor II Related Classifications

HY-136736 Related Classifications

Bioz