Z-LLNle-CHO
Based on 1 Customer Validation
Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia.
For research use only. We do not sell to patients.
- Purity: 97.18%
- CAS No.: 133407-83-7
- Formula: C26H41N3O5
- Molecular Weight:475.62
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Apoptosis Compound Library
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Metabolism/Protease Compound Library
HY-L012
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Neuronal Signaling Compound Library
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Differentiation Inducing Compound Library
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Biological Activity
Z-LLNle-CHO (0-5 μM or 0-3 μM; 72 h) results in a dose-dependent decrease in cell viability/proliferation in six breast cancer cell lines[1].
Z-LLNle-CHO shows proteasome inhibitory activity, which contributes to cytotoxicity to MCF-7 cells[1].
Z-LLNle-CHO blocks Akt-mediated pro-survival pathways and induces caspase- and ROS-dependent cell apoptosis in Nalm6 and 697 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, BT474, T47D, MDA-MB-231, SKBR3, and MDA-MB-468 cells
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Concentration:0-5 µM (for MCF-7); 0-3 µM
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Incubation Time:72 h
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Result:Inhibited MCF-7, BT474, T47D, MDA-MB-231, SKBR3, and MDA-MB-468 cells with ED50 values of 3.25, 2.5, 2.4, 1.8, 1.6, and 1.4 μM, respectively.
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Cell Line:Precursor-B ALL cells
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Concentration:0-2.5 µM
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Incubation Time:18-24 h
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Result:Induced cell apoptosis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female SCID/NOD mice (6-8-week-old; precursor-B ALL xenograft model)[2].
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Dosage:5 mg/kg
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Administration:Subcutaneous injection; single daily for 12 days
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Result:Delayed or prevented engraftment of B-lymphoblasts in 50% of the animals comprising the experimental group.
Chemical Information
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CAS No. 133407-83-7
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Appearance Solid
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Molecular Weight 475.62
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Formula C26H41N3O5
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Color White to off-white
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Synonyms
Z-Leu-Leu-Nle-CHO; GSII
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (210.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Han J, et al. The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition. Breast Cancer Res. 2009;11(4):R57. [Content Brief]
[2]. Meng X, et al. GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia. Leukemia. 2011 Jul;25(7):1135-46. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1025 mL | 10.5126 mL | 21.0252 mL | 52.5630 mL |
| 5 mM | 0.4205 mL | 2.1025 mL | 4.2050 mL | 10.5126 mL | |
| 10 mM | 0.2103 mL | 1.0513 mL | 2.1025 mL | 5.2563 mL | |
| 15 mM | 0.1402 mL | 0.7008 mL | 1.4017 mL | 3.5042 mL | |
| 20 mM | 0.1051 mL | 0.5256 mL | 1.0513 mL | 2.6281 mL | |
| 25 mM | 0.0841 mL | 0.4205 mL | 0.8410 mL | 2.1025 mL | |
| 30 mM | 0.0701 mL | 0.3504 mL | 0.7008 mL | 1.7521 mL | |
| 40 mM | 0.0526 mL | 0.2628 mL | 0.5256 mL | 1.3141 mL | |
| 50 mM | 0.0421 mL | 0.2103 mL | 0.4205 mL | 1.0513 mL | |
| 60 mM | 0.0350 mL | 0.1752 mL | 0.3504 mL | 0.8760 mL | |
| 80 mM | 0.0263 mL | 0.1314 mL | 0.2628 mL | 0.6570 mL | |
| 100 mM | 0.0210 mL | 0.1051 mL | 0.2103 mL | 0.5256 mL |
Z-LLNle-CHO Related Classifications
HY-120234 Related Classifications
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