1. Neuronal Signaling Stem Cell/Wnt Metabolic Enzyme/Protease Apoptosis
  2. γ-secretase Proteasome Apoptosis
  3. Z-LLNle-CHO

Z-LLNle-CHO  (Synonyms: Z-Leu-Leu-Nle-CHO; GSII)

Cat. No.: HY-120234
Handling Instructions

Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Z-LLNle-CHO Chemical Structure

Z-LLNle-CHO Chemical Structure

CAS No. : 133407-83-7

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Description

Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia[1][2].

In Vitro

Z-LLNle-CHO (0-5 µM or 0-3 µM; 72 h) results in a dose-dependent decrease in cell viability/proliferation in six breast cancer cell lines[1].
Z-LLNle-CHO shows proteasome inhibitory activity, which contributes to cytotoxicity to MCF-7 cells[1].
Z-LLNle-CHO blocks Akt-mediated pro-survival pathways and induces caspase- and ROS-dependent cell apoptosis in Nalm6 and 697 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MCF-7, BT474, T47D, MDA-MB-231, SKBR3, and MDA-MB-468 cells
Concentration: 0-5 µM (for MCF-7); 0-3 µM
Incubation Time: 72 h
Result: Inhibited MCF-7, BT474, T47D, MDA-MB-231, SKBR3, and MDA-MB-468 cells with ED50 values of 3.25, 2.5, 2.4, 1.8, 1.6, and 1.4 μM, respectively.

Apoptosis Analysis[2]

Cell Line: Precursor-B ALL cells
Concentration: 0-2.5 µM
Incubation Time: 18-24 h
Result: Induced cell apoptosis.
In Vivo

Z-LLNle-CHO (5 mg/kg; s.c.; single daily for 12 days) inhibits engraftment of B-lymphoblasts in precursor-B ALL xenograft model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female SCID/NOD mice (6-8-week-old; precursor-B ALL xenograft model)[2].
Dosage: 5 mg/kg
Administration: Subcutaneous injection; single daily for 12 days
Result: Delayed or prevented engraftment of B-lymphoblasts in 50% of the animals comprising the experimental group.
Molecular Weight

475.62

Formula

C26H41N3O5

CAS No.
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Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Z-LLNle-CHO
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