133407-83-7
133407-83-7
Chemical Structure
Z-LLNle-CHO
Synonym(s): Z-Leu-Leu-Nle-CHO; GSII
- CAS No.: 133407-83-7
- Formula:C26H41N3O5
- Molecular Weight:475.62
IUPAC Name: benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxohexan-2-yl)amino)pentan-2-yl)amino)-1-oxopentan-2-yl)carbamate
InChIKey: RNPDUXVFGTULLP-VABKMULXSA-N
SMILES: O=C([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)N[C@@H](CC(C)C)C(N[C@H](C=O)CCCC)=O
Biological Activity: Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Z-LLNle-CHO | 97.18% | Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia. | ||||||||||||||||||||
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References
- [1]. Han J, et al. The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition. Breast Cancer Res. 2009;11(4):R57. [Content Brief]
- [2]. Meng X, et al. GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia. Leukemia. 2011 Jul;25(7):1135-46. [Content Brief]
