SIB-1281
SIB-1281 is a β-secretase inhibitor that inhibits β-site cleavage of amyloid precursor protein (APP) and reduces the production of Aβ peptides. SIB-1281 decreases the generation of Aβ40 and Aβ42, and promotes the secretion of α-sAPP. SIB-1281 can be used in studies related to Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 181139-85-5
- Formula: C26H39N3O5
- Molecular Weight:473.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SIB-1281 inhibits Aβ40 and Aβ42 production with an IC50 of 800 nM, potentiates α-sAPP secretion with an EC50 of 650 nM, and does not alter APP holoprotein levels in human glioblastoma cells transfected with wild-type or mutant APP695 cDNAs[1].
SIB-1281 (16 h) inhibits over 95% of all measured Aβ peptide variant production and increases α-sAPP secretion by ~10-fold in human glioblastoma cells stably expressing Swedish/Indiana mutant APP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 181139-85-5
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Molecular Weight 473.60
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Formula C26H39N3O5
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SMILES
O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C=O)CC(C)=C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SIB-1281 Related Classifications
HY-187132 Related Classifications
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