2. Metabolic Enzyme/Protease
  3. Proteasome
  4. Berberine-amide-m-PhBA chloride

Berberine-amide-m-PhBA chloride (Compound 8b) is a selective anti-breast cancer agent. Berberine-amide-m-PhBA chloride may inhibit the proteasome by interacting with the 20S proteasome β5 subunit. Berberine-amide-m-PhBA chloride can be used in the research of breast cancer.

For research use only. We do not sell to patients.

Berberine-amide-m-PhBA chloride

Berberine-amide-m-PhBA chloride Chemical Structure

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Berberine-amide-m-PhBA chloride Related Antibodies

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Description

Berberine-amide-m-PhBA chloride (Compound 8b) is a selective anti-breast cancer agent. Berberine-amide-m-PhBA chloride may inhibit the proteasome by interacting with the 20S proteasome β5 subunit. Berberine-amide-m-PhBA chloride can be used in the research of breast cancer[1].

In Vitro

Berberine-amide-m-PhBA chloride inhibits proliferation of MDA-MB-468 human breast cancer cells with an IC50 of 13.4 ± 6.8 μM, shows no activity against MCF-7 or U251 cells, has low toxicity to HEK-293 normal cells, and exhibits a selectivity index of 1.59 for MDA-MB-468 cells over HEK-293 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Berberine-amide-m-PhBA chloride Related Antibodies
Molecular Weight

504.73

Formula

C26H22BClN2O6
SMILES

COC1=C(NC(C2=CC(B(O)O)=CC=C2)=O)C3=C[N+]4=C(C=C3C=C1)C5=CC6=C(OCO6)C=C5CC4.[Cl-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Berberine-amide-m-PhBA chloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Berberine-amide-m-PhBAProteasomeblood-brain barrierMDA-MB-468 human breast cancer cellsU251 cellsHEK-293 cellsgastrointestinal absorptionLipinski's rule of five20S proteasome β5 subunitMCF-7 cellsbreast cancer cellsnormal human embryonic kidney cellsInhibitorinhibitorinhibit

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Berberine-amide-m-PhBA chloride
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HY-181940
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