Berberine-amide-m-PhBA chloride
Berberine-amide-m-PhBA chloride (Compound 8b) is a selective anti-breast cancer agent. Berberine-amide-m-PhBA chloride may inhibit the proteasome by interacting with the 20S proteasome β5 subunit. Berberine-amide-m-PhBA chloride can be used in the research of breast cancer.
For research use only. We do not sell to patients.
- Formula: C26H22BClN2O6
- Molecular Weight:504.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Berberine-amide-m-PhBA chloride inhibits proliferation of MDA-MB-468 human breast cancer cells with an IC50 of 13.4 ± 6.8 μM, shows no activity against MCF-7 or U251 cells, has low toxicity to HEK-293 normal cells, and exhibits a selectivity index of 1.59 for MDA-MB-468 cells over HEK-293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 504.73
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Formula C26H22BClN2O6
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SMILES
COC1=C(NC(C2=CC(B(O)O)=CC=C2)=O)C3=C[N+]4=C(C=C3C=C1)C5=CC6=C(OCO6)C=C5CC4.[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Berberine-amide-m-PhBA chloride Related Classifications
HY-181940 Related Classifications
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