20S Proteasome-IN-3
20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC50=1.64 μM). 20S Proteasome-IN-3 shows anti-tumor proliferation activity.
For research use only. We do not sell to patients.
- CAS No.: 1803040-07-4
- Formula: C34H43N3O8
- Molecular Weight:621.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.64 μM (20S proteasome β5 subunit)[1]
20S Proteasome-IN-3 (Compound 10b) (5.34-9.69 μM, 18-24 h) exhibits significant inhibition against A375, SW480, DU145, and HeLa cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A375, SW480, DU145, and HeLa cell lines
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Concentration:5.34-9.69 μM
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Incubation Time:18-24 hours
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Result:Inhibited the proliferation of SW480, DU145, A375 and HeLa cells with the IC50s of 5.34, 9.69, 5.66 and 7.03 μM, respectively.
Chemical Information
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CAS No. 1803040-07-4
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Molecular Weight 621.72
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Formula C34H43N3O8
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SMILES
OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CC(C)C)C(C2=CC=CO2)=O)=O)NC([C@@H](NC(OC(C)(C)C)=O)CC3=CC=C(C=C3)OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Qi Sun, et al. Design and synthesis of tripeptidyl furylketones as selective inhibitors against the β5 subunit of human 20S proteasome. Eur J Med Chem. 2020 Apr 15;192:112160. [Content Brief]
[2]. Qi Sun, et al. Synthesis, bioactivity, docking and molecular dynamics studies of furan-based peptides as 20S proteasome inhibitors. ChemMedChem. 2015 Mar;10(3):498-510. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
20S Proteasome-IN-3 Related Classifications
HY-150591 Related Classifications
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