1803040-07-4
1803040-07-4
Chemical Structure
20S Proteasome-IN-3
- CAS No.: 1803040-07-4
- Formula:C34H43N3O8
- Molecular Weight:621.72
IUPAC Name: tert-butyl ((S)-1-(((S)-1-(((S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-3-(4-methoxyphenyl)-1-oxopropan-2-yl)carbamate
InChIKey: PIHVFDCGCIKOJQ-KCHLEUMXSA-N
SMILES: OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CC(C)C)C(C2=CC=CO2)=O)=O)NC([C@@H](NC(OC(C)(C)C)=O)CC3=CC=C(C=C3)OC)=O
Biological Activity: 20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC50=1.64 μM)[1][2]. 20S Proteasome-IN-3 shows anti-tumor proliferation activity[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
20S Proteasome-IN-3 | 20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC50=1.64 μM). 20S Proteasome-IN-3 shows anti-tumor proliferation activity. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Qi Sun, et al. Design and synthesis of tripeptidyl furylketones as selective inhibitors against the β5 subunit of human 20S proteasome. Eur J Med Chem. 2020 Apr 15;192:112160. [Content Brief]
- [2]. Qi Sun, et al. Synthesis, bioactivity, docking and molecular dynamics studies of furan-based peptides as 20S proteasome inhibitors. ChemMedChem. 2015 Mar;10(3):498-510. [Content Brief]
Keywords
