Tyropeptin A-4
Tyropeptin A-4 (TP-101) is a potent proteasome inhibitor with the ability to inhibit mammalian 20S proteasome activity. Tyropeptin A-4 exerts its inhibitory effect by binding to the site responsible for trypsin-like activity. Tyropeptin A-4 derivative TP-104 has a 20-fold increase in inhibitory activity over Tyropeptin A. TP-110 specifically inhibits trypsin-like activity without affecting PGPH and trypsin-like activity.
For research use only. We do not sell to patients.
- CAS No.: 688737-89-5
- Formula: C31H41N3O6
- Molecular Weight:551.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
0.33 μM
Compound: TP-101
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Inhibitory concentration to inhibit chymotrypsin-like activity of 20S proteasome prepared from human leukemia HL-60 cells was determined
Inhibitory concentration to inhibit chymotrypsin-like activity of 20S proteasome prepared from human leukemia HL-60 cells was determined
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[PMID: 15780623] |
| HL-60 | IC50 |
17 μM
Compound: TP-101
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Inhibitory concentration to inhibit the PGPH activity of 20S proteasome prepared from human leukemia HL-60 cells was determined
Inhibitory concentration to inhibit the PGPH activity of 20S proteasome prepared from human leukemia HL-60 cells was determined
|
[PMID: 15780623] |
| HL-60 | IC50 |
3 μM
Compound: TP-101
|
Inhibitory concentration to inhibit trypsin-like activity of 20S proteasome from human leukemia HL-60 cells was determined
Inhibitory concentration to inhibit trypsin-like activity of 20S proteasome from human leukemia HL-60 cells was determined
|
[PMID: 15780623] |
Chemical Information
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CAS No. 688737-89-5
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Molecular Weight 551.67
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Formula C31H41N3O6
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SMILES
OC(C=C1)=CC=C1C[C@H](NC(CC2CCCCC2)=O)C(N[C@@H](C(C)C)C(NC(C=O)CC3=CC=C(C=C3)O)=O)=O
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Synonyms
TP-101
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tyropeptin A-4 Related Classifications
HY-126874 Related Classifications
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