688737-89-5
Chemical Structure
Tyropeptin A-4
Synonym(s): TP-101
- CAS No.: 688737-89-5
- Formula:C31H41N3O6
- Molecular Weight:551.67
IUPAC Name: (2S)-2-((S)-2-(2-cyclohexylacetamido)-3-(4-hydroxyphenyl)propanamido)-N-(1-(4-hydroxyphenyl)-3-oxopropan-2-yl)-3-methylbutanamide
InChIKey: PBHZSZHBJWAKIL-TXJYOHDVSA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC(CC2CCCCC2)=O)C(N[C@@H](C(C)C)C(NC(C=O)CC3=CC=C(C=C3)O)=O)=O
Biological Activity: Tyropeptin A-4 (TP-101) is a potent proteasome inhibitor with the ability to inhibit mammalian 20S proteasome activity. Tyropeptin A-4 exerts its inhibitory effect by binding to the site responsible for trypsin-like activity. Tyropeptin A-4 derivative TP-104 has a 20-fold increase in inhibitory activity over Tyropeptin A. TP-110 specifically inhibits trypsin-like activity without affecting PGPH and trypsin-like activity[1].
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Tyropeptin A-4 | Tyropeptin A-4 (TP-101) is a potent proteasome inhibitor with the ability to inhibit mammalian 20S proteasome activity. Tyropeptin A-4 exerts its inhibitory effect by binding to the site responsible for trypsin-like activity. Tyropeptin A-4 derivative TP-104 has a 20-fold increase in inhibitory activity over Tyropeptin A. TP-110 specifically inhibits trypsin-like activity without affecting PGPH and trypsin-like activity. | |||||||||||||||||||||
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