clasto-Lactacystin β-lactone
Based on 1 Customer Validation
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 154226-60-5
- Formula: C10H15NO4
- Molecular Weight:213.23
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
20S proteasome[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
1600 nM
Compound: 2
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Inhibition of NF-kB activation in HEK293 cells
Inhibition of NF-kB activation in HEK293 cells
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[PMID: 15916417] |
| RPMI-8226 | IC50 |
3300 nM
Compound: 2
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Cytotoxic activity against RPMI 8226 cells
Cytotoxic activity against RPMI 8226 cells
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[PMID: 15916417] |
Clasto-Lactacystin β-lactone is a natural active metabolite of lactacystin, which is a metabolite of Streptomyces. Clasto-Lactacystin β-lactone is the cell cycle progression in an osteosarcoma cell line[1]. Clasto-Lactacystin β-lactone is an irreversible 20S proteasome inhibitor, and also acts as a partial inhibitor of branched amino acid preferring peptidase (BrAAP). β-Lactone inactivates approximately 60% of the BrAAP activity rapidly, and the remaining 40% of the BrAAP activity is inactivated by β-lactone at a 50-fold slower rate[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 154226-60-5
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Appearance Liquid
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Molecular Weight 213.23
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Formula C10H15NO4
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Color Colorless to light yellow
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SMILES
O=C([C@H](C)[C@]1([H])O2)N[C@@]1([C@@H](O)C(C)C)C2=O
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Synonyms
Omuralide; β-Clastolactacystin
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (275 KB)
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SDS (546 KB)
- English - EN (546 KB)
- Français - FR (546 KB)
- Deutsch - DE (546 KB)
- Norwegian - NO (546 KB)
- Español - ES (546 KB)
- Swedish - SV (546 KB)
- Italian - IT (546 KB)
- Korean - KR (546 KB)
- Portuguese - PT (546 KB)
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Handling Instructions (2659 KB)
References
[1]. Fenteany G, et al. A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3358-62. [Content Brief]
[2]. McCormack TA, et al. Kinetic studies of the branched chain amino acid preferring peptidase activity of the 20S proteasome: development of a continuous assay and inhibition by tripeptide aldehydes and clasto-lactacystin beta-lactone. Biochemistry. 1998 May 26;37(21):7792-800. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
clasto-Lactacystin β-lactone Related Classifications
HY-108549 Related Classifications
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