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Results for "

MG degrader3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Anaplastic lymphoma kinase (ALK) (2) Androgen Receptor (1) Apoptosis (4) Atg8/LC3 (1) ATM/ATR (3) AUTACs (1) Autophagy (1) Bcl-2 Family (3) BCL6 (2) Btk (1) c-Met/HGFR (1) Caspase (3) CCR (1) CDK (1) Checkpoint Kinase (Chk) (1) DNA/RNA Synthesis (1) E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (8) EGFR (2) Epigenetic Reader Domain (8) Epoxide Hydrolase (1) Estrogen Receptor/ERR (3) FAK (2) Ferroptosis (1) FKBP (1) FLT3 (1) HDAC (4) Histone Acetyltransferase (1) Histone Methyltransferase (1) HyT (2) IAP (1) IKZF Family (1) Interleukin Related (1) IRAK (1) Ligands for E3 Ligase (5) Ligands for Target Protein for PROTAC (11) LRRK2 (1) MAP4K (1) MDM-2/p53 (2) Mixed Lineage Kinase (2) Molecular Glues (9) Myosin (3) NAMPT (1) NEKs (1) NF-κB (1) NOD-like Receptor (NLR) (1) PARP (1) PD-1/PD-L1 (4) PIN1 (1) Polo-like Kinase (PLK) (2) PROTAC Linkers (9) PROTAC-Linker Conjugates for PAC (2) PROTACs (44) Pyroptosis (1) Ras (3) Reference Standards (1) SARS-CoV (3) SHP2 (1) SNIPERs (2) SOS1 (1) Src (2) STAT (4) STING (1) Target Protein Ligand-Linker Conjugates (3) Transglutaminase (1) Virus Protease (3) YAP (1) α-synuclein (1)
By Research Areas:	Cancer (77) Cardiovascular Disease (1) Endocrinology (1) Infection (5) Inflammation/Immunology (13) Metabolic Disease (1) Neurological Disease (5)
Click Chemistry:	PROTAC Synthesis (1) Azide (3)

104

Inhibitors & Agonists

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-168625

VAV1 degrader-3	Molecular Glues	Inflammation/Immunology
VAV1 degrader-3 (Example 185) is an orally active VAV1 molecular glue degrader (DC₅₀: 7 nM). VAV1 degrader-3 reduces immune cell activation, immune cell proliferation and the production of various cytokines. VAV1 degrader-3 can be used for research of inflammatory or autoimmune disorder. VAV1 degrader-3 inhibits disease progression in experimntal autoimmune encephalomyelitis (EAE) mouse model, Collagen-induced arthritis (CIA) mouse model, etc. .

HY-177456

STAT6 degrader-3	STAT	Inflammation/Immunology
STAT6 degrader-3 (Compound I-1) is a potent and selective STAT6 degrader with a DC₅₀ of <1 nM. STAT6 degrader-3 can be used in the research of Type 2 immune and allergic responses .

HY-164827

*CDK2 degrader* 3**	Molecular Glues CDK	Cancer
CDK2 degrader 3 is a selective CDK2 molecular glue-like degrader. CDK2 degrader 3 induces G1 cell cycle arrest in CCNE1-amplified cancer cells. CDK2 degrader 3 is applicable to breast cancer-related research .

HY-136857

BRD4 degrader-3	Epigenetic Reader Domain	Cancer
BRD4 degrader-3 is a potent bromodomain BRD4 degrader extracted from patent WO2020055976A1, example 1a, has IC₅₀s of 15.5 and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively . PROTAC BRD4 Degrader-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139185

PROTAC ERRα Degrader-3 1 Publications Verification	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERRα Degrader-3 is a potent and selective ERRα degrader based on von Hippel-Lindau ligand. PROTAC ERRα Degrader-3 is capable of specifically degrading ERRα protein by >80% at a concentration of 30 nM. PROTAC ERRα Degrader-3 is inactive against ERRβ and ERRγ proteins .

HY-69260

tert-Butyl 4-formylpiperidine-1-carboxylate	PROTAC Linkers	Others
tert-Butyl 4-formylpiperidine-1-carboxylate is a PROTAC linker and can be used in the synthesis of PROTAC BRM/BRG1 degrader-3 (HY-168251) .

HY-152134

HDAC6 degrader-3	HDAC PROTACs	Cancer
HDAC6 degrader-3 is a potent and selective HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with a DC₅₀ value of 19.4 nM. HDAC6 degrader-3 has IC₅₀s of 4.54 nM and 0.647 μM for HDAC6 and HDAC1, respectively. HDAC6 degrader-3 causes strong hyperacetylation of α-tubulin .

HY-135382A

PROTAC IRAK4 degrader-3	PROTACs IRAK	Inflammation/Immunology
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau .

HY-168054

PROTAC K-Ras Degrader-3	PROTACs Ras	Cancer
PROTAC K-Ras Degrader-3 (compound 40) is a PROTAC degrader of K-Ras with a DC₅₀ of ≤ 1 nM against SW620 KRAS G12D, and a GI₅₀ of ≤ 10 nM against SW620 3D cell growth. PROTAC K-Ras Degrader-3 can be utilized in cancer research, such as non-small-cell lung cancer (NSCLC) .

HY-132997

PROTAC Bcl-xL degrader-3	PROTACs Bcl-2 Family	Cancer
PROTAC Bcl-xL degrader-3 is a potent PROTAC Bcl-xL degrader. PROTAC Bcl-xL degrader-3 forms ternary complexes with the VHL-complex and BCL-XL. PROTAC Bcl-xL degrader-3 can be used in research on acute lymphoblastic leukemia .

HY-173414

PROTAC STING degrader-3	PROTACs STING NF-κB	Inflammation/Immunology
PROTAC STING degrader-3 is a STING PROTAC degrader (DC₅₀: 0.62 μM). PROTAC STING degrader-3 induces STING degradation via the ubiquitin-proteasome pathway. PROTAC STING degrader-3 exerts anti-inflammatory effects by inhibiting STING/TBK1/NF-κB signaling. PROTAC STING degrader-3 has renal protective effects and can be used in the study of acute kidney injury (AKI) .

HY-135345

PROTAC FKBP Degrader-3 1 Publications Verification	PROTACs FKBP	Cancer
PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an von Hippel-Lindau binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader .

HY-176919

PROTAC STAT6 degrader-3	PROTACs STAT	Inflammation/Immunology Cancer
PROTAC STAT6 degrader-3 is a potent STAT6 PROTAC degrader with a DC₅₀ of less than 1 nM. PROTAC STAT6 degrader-3 can be used for research on allergic/inflammatory diseases and cancer .

HY-114229

PROTAC BET degrader-3 1 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BET Degrader-3 is a PROTAC connected by ligands for von Hippel-Lindau and BET.

HY-163502

PROTAC STAT3 degrader-3	PROTACs STAT	Cancer
PROTAC STAT3 degrader-3 (S3D1) is a STAT3 PROTAC degrader with anticancer activity (Structural notes: (Blue: Cereblon ligand (HY-10984), Black: linker; Pink: Pentafluorobenzenesulfonamide(Me)-CH2-CONH-benzamide (HY-163526)) .

HY-128842

PROTAC MDM2 Degrader-3 1 Publications Verification	PROTACs MDM-2/p53	Cancer
PROTAC MDM2 Degrader-3 is a MDM2 self-degrading (dimeric) PROTAC. PROTAC MDM2 Degrader-3 can be used in cancer research .

HY-136001

*PROTAC α-synuclein degrader* 3**	PROTACs α-synuclein	Neurological Disease
PROTAC α-synuclein degrader 3 (Compound 5) is a selective α-synuclein PROTAC degrader. PROTAC α-synuclein degrader 3 can promote the ubiquitination and degradation of α-synuclein. PROTAC α-synuclein degrader 3 can be used for Parkinson's disease research (Pink: target protein ligand (HY-W278021); Black: linker; HY-133302; Blue: E3 ligase VHL ligand (HY-112078)) .

HY-155506

NAMPT degrader-3	NAMPT	Cancer
NAMPT degrader-3 (compound C5) is a NAMPT degrader, depending on VHL- and proteasome manner. NAMPT degrader-3 displays cytotoxicity and inhibits A2780 cells proliferation .

HY-176386

E3 ligase Ligand 68	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 68 is an E3 ligase ligand that can be used in the synthesis of PROTACs, such as PROTAC ER Degrader-3 (HY-128527) .

HY-171140

*PROTAC HDAC6 degrader* 3**	PROTACs HDAC	Cancer
PROTAC HDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader for HDAC6 with an IC₅₀ of 686 nM and a DC₅₀ of 171 nM. PROTAC HDAC6 degrader 3 promotes the acetylation of α-tubulin . (Pink: ligand for target protein (HY-171141); Blue: ligand for E3 ligase VHL (HY-150803))

HY-152145

PROTAC SOS1 degrader-3	SOS1 PROTACs Ras	Cancer
PROTAC SOS1 degrader-3 is a potent PROTAC SOS1 degrader. PROTAC SOS1 degrader-3 effectively targeted SOS1 for degradation through the ubiquitin-proteasome system .

HY-178797

PROTAC LRRK2 Degrader-3	PROTACs LRRK2	Neurological Disease Inflammation/Immunology
PROTAC LRRK2 Degrader-3 (compound 6) is a PROTAC LRRK2 degrader with a DC₅₀ of 0.17 nM. PROTAC LRRK2 Degrader-3 can be used for research in Parkinson’s disease and inflammation .

HY-153536

PROTAC BTK Degrader-3	PROTACs Btk	Cancer
PROTAC BTK Degrader-3 is a potent BTK degrader with a DC₅₀ value of 10.9 nM of BTK degradation in Mino cells. PROTAC BTK Degrader-3 has the potential for B-cell malignancies, including chronic lymphoid malignancies research .

HY-145400

PROTAC BRD9 Degrader-3	PROTACs	Cancer
PROTAC BRD9 Degrader-3 is a BRD9 bifunctional degrader for researching cancer.

HY-177728

MG degrader 3	Molecular Glues E1/E2/E3 Enzyme	Cancer
MG degrader 3 (Compound CM-3) is a molecular glucose degrading agent that targets the CRBN protein. MG degrader 3 has certain anti proliferative activity in MM.1S cells (IC₅₀ = 8.7 nM). MG degrader 3 can be used for cancer research .

HY-168131

PROTAC EZH2 Degrader-3	PROTACs Histone Methyltransferase Apoptosis	Cancer
PROTAC EZH2 Degrader-3 (compound ZJ-20) is a EZH2 PROTAC degrader. PROTAC EZH2 Degrader-3 (5 μM, 24 h) not only potently inhibits the expression of EZH2 protein, but also had a strong inhibits effect on the expression levels of other subunits of PRC2 as well as H3k27me3 protein. PROTAC EZH2 Degrader-3 shows anti-proliferative activity and blocks the cell cycle in the G0-G1 phase and induces cell apoptosis((Blue: cereblon ligand Pomalidomide (HY-10984), Black: linker HY-W361751；Pink: EZH2 inhibitor Tazemetostat (HY-13803)) .

HY-163526

STAT3-IN-26	Ligands for Target Protein for PROTAC STAT	Cancer
STAT3-IN-26 is the ligand for the target protein STAT3 in PROTAC STAT3 degrader-3 (HY-163502), which can be used for the synthesis of PROTACs .

HY-139707

PROTAC CBP/P300 Degrader-3 Thalidomide-NH-CBP/p300 ligand 2	PROTACs Molecular Glues Epigenetic Reader Domain	Cancer
PROTAC CBP/P300 Degrader-3 (P-007) is a PROTAC-based CBP and p300 degrader (extracted from patent WO2020173440) .

HY-128527

PROTAC ER Degrader-3	PROTAC-Linker Conjugates for PAC Estrogen Receptor/ERR	Cancer
PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab) .

HY-178938

AR Degrader-3	Molecular Glues Androgen Receptor Caspase Apoptosis	Endocrinology Cancer
AR Degrader-3 is an orally active molecular glue that targets AR/ARV7 and induces the degradation of AR and ARV7 through the ubiquitin-proteasome pathway (UPP). AR Degrader-3 directly interacts with the ligand-binding domain (LBD) and the N-terminal domain (NTD) of AR. AR Degrader-3 effectively suppresses the transcriptional activity of wild-type AR (AR-WT), AR mutants, and ARV7. AR Degrader-3 downregulates the mRNA and protein levels of downstream AR target genes, thereby overcoming antiandrogen resistance mediated by ARV7 and AR point mutations. AR Degrader-3 induces apoptosis in Enzalutamide (HY-70002) (ENZa)-resistant cells and increases cleaved caspase-3 protein levels. AR Degrader-3 can be used for the study of castration-resistant prostate cancer (CRPC) .

HY-162245

PROTAC SMARCA2 degrader-3	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-3 is a PROTAC degrader of the SWI/SNF ATPase subunits, SMARCA2. PROTAC SMARCA2 degrader-3 has anticancer effects (WO2023244764A1; Compound 153) .

HY-168910

PROTAC c-Met degrader-3	PROTACs c-Met/HGFR	Cancer
PROTAC c-Met degrader-3 (Compound 22b) is a c-Met PROTAC degrader. PROTAC c-Met degrader-3 promotes ubiquitination and degradation of c-Met (DC₅₀ of 0.59 nM in EBC-1 cells). PROTAC c-Met degrader-3 can be used for the research of lung cancer (Pink: c-Met ligand (HY-14721); Blue: E3 ligase CRBN ligand (HY-W249500); linker + E3 ligase ligand (HY-168911)) .

HY-175204

SHP2 protein degrader-3	AUTACs SHP2 Apoptosis Autophagy Atg8/LC3	Cancer
SHP2 protein degrader-3 is a SHP2 AUTAC degrader. SHP2 protein degrader-3 shows dose-dependent SHP2 degradation ability (DC₅₀ = 3.22 μM) and anti-tumor activity (IC₅₀ = 5.59 μM) in HeLa cells. SHP2 protein degrader-3 induces degradation through the LC3-mediated autophagy pathway, which can be inhibited by lysosome inhibitors. SHP2 protein degrader-3 induces apoptosis in various cancer cells (HeLa cells, HepG2 cells, LoVo cells, Huh-7 cells) (SHP2 Ligand : (HY-100388); LC3 Ligand: (HY-10542); Linker : (HY-128834)) .

HY-163810

BRD9 Degrader-3	Molecular Glues Epigenetic Reader Domain	Cancer
BRD9 Degrader-3 (compound B20) is a BRD9 molecular glue, with a DC₅₀ of <1.25 nM .

HY-111842

PROTAC CRABP-II Degrader-3	SNIPERs PROTACs	Cancer
PROTAC CRABP-II Degrader-3 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on IAP ligand .

HY-168722

PROTAC PARP1 degrader-3	PARP PROTACs	Cancer
PROTAC PARP1 degrader-3 (Compound C6) is a PROTAC degrader for PARP1 with a DC₅₀ of 58.14 nM. PROTAC PARP1 degrader-3 exhibits cytotoxicity in cancer cell SW-620 and LOVO with IC₅₀ of 1.63 μM and 2.84 μM. PROTAC PARP1 degrader-3 exhibits a synergistic effect with SN-38 (HY-13704) in BRCA-mutated colon cancer cell with a combination index (CI) of 0.487. (Blue: Ligand for E3 ligase Cereblon (HY-23095); Pink: Ligand for target protein (HY-10619); Black: Linker (HY-16872))

HY-135558

PROTAC BRD4 Degrader-3	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-3 (compound 1004.1) is an efficacious PROTAC connected by ligands for von Hippel-Lindau and BRD4 .

HY-157426

GSPT1 degrader-3	Epigenetic Reader Domain PROTACs	Cancer
GSPT1 degrader-3 (Pro-2) is a CRBN-based PROTAC degrader for BRD, with a DC₅₀ of 21.1 nM (4h) .

HY-161933

1-Adamantane-amide-C7-NH2	PROTAC Linkers	Cancer
1-Adamantane-amide-C7-NH2 is the linker, which can be used for syntheisis of PROTAC GPX4 degrader-3 (HY-161930) .

HY-144605

*PROTAC EGFR degrader* 3**	EGFR PROTACs	Cancer
PROTAC EGFR degrader 3 is a potent PROTAC EGFR degrader. PROTAC EGFR degrader 3 shows excellent cellular activity against the H1975 and HCC827 cells with high selectively. PROTAC EGFR degrader 3 shows that the lysosome is involved in the degradation process of EGFR mutant degradation .

HY-168076

(S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-CH2-Me-PIP-Boc	PROTAC-Linker Conjugates for PAC	Cancer
(S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-CH2-Me-PIP-Boc consists of E3 ligase ligand and PROTAC linker of PROTAC K-Ras Degrader-3 (HY-168054). (S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-CH2-Me-PIP-Boc is promising for research of cancers .

HY-168056

KRAS ligand 5	Ligands for Target Protein for PROTAC Ras	Others
KRAS ligand 5 is the target protein ligand for PROTAC K-Ras Degrader-3 (HY-168054). PROTAC K-Ras Degrader-3 can specifically degrade KRAS mutated proteins .

HY-178830

Azacyclohexane-O-cyclohexane-C-(OCH3)2	PROTAC Linkers	Neurological Disease
Azacyclohexane-O-cyclohexane-C-(OCH3)2 is a PROTAC linker that can be used to synthesize PROTAC LRRK2 Degrader-3 (HY-178797). PROTAC LRRK2 Degrader-3 is a potent LRRK2 PROTAC degrader with anti-neuroinflammatory activity .

HY-168055

(S)-Deoxy-thalidomide	Ligands for E3 Ligase	Cancer
(S)-Deoxy-thalidomide is an E3 ubiquitin ligase ligand. (S)-Deoxy-thalidomide can be linked to the target protein ligand through a linker to form PROTAC K-Ras Degrader-3 (HY-168054). PROTAC K-Ras Degrader-3 can target KRAS mutant proteins for degradation .

HY-178828

E3 ligase Ligand 29-azacyclohexane-O-cyclohexane-CO	E3 Ligase Ligand-Linker Conjugates	Neurological Disease
E3 ligase Ligand 29-azacyclohexane-O-cyclohexane-CO is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC LRRK2 Degrader-3 (HY-178797). PROTAC LRRK2 Degrader-3 is a potent LRRK2 PROTAC degrader with anti-neuroinflammatory activity .

HY-168253

E3 ligase Ligand 37	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 37 is a ligand for E3 ubiquitin ligase of PROTAC BRM/BRG1 degrader-3 (HY-168251) .

HY-168551

PROTAC ALK degrader-3	PROTACs Anaplastic lymphoma kinase (ALK)	Cancer
PROTAC ALK degrader-3 (4B) is an orally active ALK degrader based on PROTACs, which can effectively induce persistent degradation of ALK fusion protein in Karpas 299 cells and strong inhibition of downstream pathways,IC₅₀ is 119.33 nM. PROTAC ALK degrader-3 exhibits antitumor activity. (Structure Note: PINK, ALK Inhibitor (HY-15656); Blue, E3 (HY-W023573); Black, linker (HY-168552)) .

HY-168252

BRM/BRG1 ligand 3	Ligands for Target Protein for PROTAC	Cancer
BRM/BRG1 ligand 3 is a target protein ligand that can be used to synthesize PROTAC BRM/BRG1 degrader-3 (HY-168251) .

HY-161791

Mpro ligand 2	Ligands for Target Protein for PROTAC SARS-CoV Virus Protease	Infection
Mpro ligand 2 (Compound 8) is the ligand for target protein, which can be used for synthesis of PROTAC SARS-CoV-2 Mpro degrader-3 (HY-161789) .

HY-162816

PROTAC HPK1 Degrader-3	PROTACs MAP4K	Cancer
PROTAC HPK1 Degrader-3 (compound C3) is an orally effective PROTAC targeting HPK1 (DC₅₀=21.26 nM). HPK1 is a negative regulator of T cell receptors, which can lead to T cell dysfunction after abnormal activation. PROTAC HPK1 Degrader-3 can inhibit SLP76 and NF-κB signaling pathways and inhibit MAPK signal transduction, and has anticancer activity and immune activation. PROTAC HPK1 Degrader-3 has a certain oral bioavailability and can be combined with PD-L1 antibody therapy to achieve a tumor growth inhibition rate of 65.58%. PROTAC HPK1 Degrader-3 is composed of E3 ligase ligand Thalidomide (HY-14658; blue part), PROTAC linker tert-Butyl 3-oxoazetidine-1-carboxylate (HY-40146; black part), and target protein ligand HPK1-IN-51 (HY-162842; red part); the activity control of the target protein ligand can be HPK1 ligand 1 (HY-162841) ^{[1] ^.}

Cat. No.	Product Name		Classification

HY-136857

BRD4 degrader-3		PROTAC Synthesis
BRD4 degrader-3 is a potent bromodomain BRD4 degrader extracted from patent WO2020055976A1, example 1a, has IC₅₀s of 15.5 and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively . PROTAC BRD4 Degrader-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-161792

N3-C5-O-C-Boc		Azide
N3-C5-O-C-Boc is a linker, which can be utilized for the synthesis of PROTAC SARS-CoV-2 Mpro degrader-3 (HY-161789) .

HY-159454

*PROTAC SMARCA2/4-degrader-3*		Azide
SMARCA2/4-degrader-3 (compound I-433) is a PROTAC *SMARCA2/4*-degrader based on VH032-NH2, with a degradation potency (DC₅₀) <100 nM in MV4-11 cells .

HY-161793

(S,R,S)-AHPC-NHCO-C-O-C5-N3		Azide
(S,R,S)-AHPC-NHCO-C-O-C5-N3 is a conjugate of ligand for E3 ligase (HY-125845) and linker (HY-161792). (S,R,S)-AHPC-NHCO-C-O-C5-N3 can be utilized for synthesis of PROTAC SARS-CoV-2 Mpro degrader-3 (HY-161789) .

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