1. Cytoskeleton
  2. Myosin
  3. ML-9 Free Base

ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (ML-9) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

ML-9 Free Base Chemical Structure

ML-9 Free Base Chemical Structure

CAS No. : 110448-31-2

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Top Publications Citing Use of Products

2 Publications Citing Use of MCE ML-9 Free Base

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Description

ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3].

In Vitro

ML9 (Free Base) (0-100 μM; 0-24 hours) has no reduction in cardiomyocyte viability, 50-100 μM significantly induces cell death[2].
ML9 (Free Base) (50 μM; 1-4 hours) significantly increases cleaved caspase-3 levels, decreased STIM1 protein levels by about 42%[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Neonatal rat ventricular myocytes (NRVM) cells
Concentration: 0, 10, 50 and 100 μM
Incubation Time: 0, 1, 4, 8 and 24 hours
Result: Decreased cell viability at 50–100 μM concentration.

Apoptosis Analysis[1]

Cell Line: Neonatal rat ventricular myocytes (NRVM) cells
Concentration: 50 μM
Incubation Time: 0, 1, 4, 8 hours
Result: Induced cardiomyocyte death through necrosis and apoptosis.
Molecular Weight

324.83

Formula

C15H17ClN2O2S

CAS No.
SMILES

O=S(N1CCNCCC1)(C2=C3C=CC=C(C3=CC=C2)Cl)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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ML-9 Free Base Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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ML-9 Free Base
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