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  3. ML-9 Free Base

ML-9 Free Base 

Cat. No.: HY-100932A
Handling Instructions

ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation.

For research use only. We do not sell to patients.

ML-9 Free Base Chemical Structure

ML-9 Free Base Chemical Structure

CAS No. : 110448-31-2

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Description

ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3].

In Vitro

ML9 (Free Base) (0-100 μM; 0-24 hours) has no reduction in cardiomyocyte viability, 50-100 μM significantly induces cell death[2].
ML9 (Free Base) (50 μM; 1-4 hours) significantly increases cleaved caspase-3 levels, decreased STIM1 protein levels by about 42%[2].

Cell Viability Assay[1]

Cell Line: Neonatal rat ventricular myocytes (NRVM) cells
Concentration: 0, 10, 50 and 100 μM
Incubation Time: 0, 1, 4, 8 and 24 hours
Result: Decreased cell viability at 50–100 μM concentration.

Apoptosis Analysis[1]

Cell Line: Neonatal rat ventricular myocytes (NRVM) cells
Concentration: 50 μM
Incubation Time: 0, 1, 4, 8 hours
Result: Induced cardiomyocyte death through necrosis and apoptosis.
Molecular Weight

324.83

Formula

C₁₅H₁₇ClN₂O₂S

CAS No.

110448-31-2

SMILES

O=S(N1CCNCCC1)(C2=C3C=CC=C(C3=CC=C2)Cl)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ML-9ML9ML 9MyosinMLCKSTIM1cardiomyocyteviabilitycaspaseInhibitorinhibitorinhibit

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ML-9 Free Base
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