2. PROTAC Apoptosis
  3. Ligands for Target Protein for PROTAC Bcl-2 Family
  4. BCL-xL ligand 3

BCL-xL ligand 3 is a BCL-xL PROTAC ligand. BCL-xL ligand 3 can be conjugated with E3 ligase Ligand (HY-112078) and linker to synthesize PROTAC Bcl-xL degrader-3 (HY-132997).

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BCL-xL ligand 3

BCL-xL ligand 3 Chemical Structure

CAS No. : 3053404-37-5

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BCL-xL ligand 3 Related Antibodies

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Description

BCL-xL ligand 3 is a BCL-xL PROTAC ligand. BCL-xL ligand 3 can be conjugated with E3 ligase Ligand (HY-112078) and linker to synthesize PROTAC Bcl-xL degrader-3 (HY-132997)[1].

IC50 & Target[1]

Bcl-xL

 

In Vitro

A PROTAC consists of two distinct ligands linked by a linker: one is a ligand for an E3 ubiquitin ligase, and the other is a ligand for a target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BCL-xL ligand 3 Related Antibodies
Molecular Weight

1058.73

Formula

C51H63ClF3N7O6S3
CAS No.
SMILES

C[C@](CN1CCNCC1)(C2)CCC(C3=CC=C(C=C3)Cl)=C2CN4CCN(C5=CC=C(C=C5)C(NS(=O)(C6=CC(S(C(F)(F)F)(=O)=O)=C(C=C6)N[C@@H](CSC7=CC=CC=C7)CCN8CCOCC8)=O)=O)CC4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BCL-xL ligand 3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCL-xL ligand 33053404-37-5Ligands for Target Protein for PROTACBcl-2 FamilyTarget Protein-binding MoietyMOLT-4 cellsBCL-xLRS4;11 cellsleukemia cellschronic lymphocytic leukemiaInhibitorinhibitorinhibit

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HY-185551
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