PROTAC BET degrader-3
Based on 1 publication(s) in Google Scholar
PROTAC BET Degrader-3 is a PROTAC connected by ligands for von Hippel-Lindau and BET.
(Pink: BET ligand (HY-112429); Blue: VHL ligand (HY-125845); Black: linker (HY-W006524)).
For research use only. We do not sell to patients.
- Purity: 99.11%
- CAS No.: 3031993-61-7
- Formula: C53H64N12O9S
- Molecular Weight:1045.22
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PROTAC BET degrader-3
MoreAll PROTACs Isoforms
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Biological Activity
BET[1]
Chemical Information
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CAS No. 3031993-61-7
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Appearance Solid
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Molecular Weight 1045.22
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Formula C53H64N12O9S
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Color Light yellow to yellow
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SMILES
CCN1N=C(C2CC2)C=C1NC3=NC(C(NCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=NC7=C3C8=CC(OC)=C(C(C(C)=NO9)=C9C)C=C8N7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Structure
PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network. [Abstract]2024 Dec 5;32(12):2352-2363.e8. PMID: 39389062
Solvent & Solubility
DMSO : 100 mg/mL (95.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (244 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9567 mL | 4.7837 mL | 9.5674 mL | 23.9184 mL |
| 5 mM | 0.1913 mL | 0.9567 mL | 1.9135 mL | 4.7837 mL | |
| 10 mM | 0.0957 mL | 0.4784 mL | 0.9567 mL | 2.3918 mL | |
| 15 mM | 0.0638 mL | 0.3189 mL | 0.6378 mL | 1.5946 mL | |
| 20 mM | 0.0478 mL | 0.2392 mL | 0.4784 mL | 1.1959 mL | |
| 25 mM | 0.0383 mL | 0.1913 mL | 0.3827 mL | 0.9567 mL | |
| 30 mM | 0.0319 mL | 0.1595 mL | 0.3189 mL | 0.7973 mL | |
| 40 mM | 0.0239 mL | 0.1196 mL | 0.2392 mL | 0.5980 mL | |
| 50 mM | 0.0191 mL | 0.0957 mL | 0.1913 mL | 0.4784 mL | |
| 60 mM | 0.0159 mL | 0.0797 mL | 0.1595 mL | 0.3986 mL | |
| 80 mM | 0.0120 mL | 0.0598 mL | 0.1196 mL | 0.2990 mL |
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