PROTAC BET degrader-3
Based on 1 publication(s) in Google Scholar
PROTAC BET Degrader-3 (Example C-55) is a BET PROTAC degrader and can be used in cancer research.
(Pink: BET ligand (HY-112429); Blue: VHL ligand (HY-125845); Black: linker (HY-W006524)).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.11%
- CAS No.: 3031993-61-7
- Formule: C53H64N12O9S
- Masse moléculaire:1045.22
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PROTAC BET degrader-3
MoreVoir tous les produits spécifiques à Isoform PROTACs
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Activité biologique
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BET |
VHL |
BET acts as an "reader" for epigenetics, regulating gene transcription by interacting with acetylated histones. BET is highly expressed in various hematological malignancies (such as acute myeloid leukemia AML, T-cell acute lymphoblastic leukemia T-ALL) and solid tumors, promoting the proliferation, survival, and metastasis of cancer cells. BET PROTAC Degrader demonstrates stronger anti-tumor activity and the potential to overcome drug resistance through protein degradation rather than simple inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3031993-61-7
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Appearance Solid
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Masse moléculaire 1045.22
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Formule C53H64N12O9S
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Color Light yellow to yellow
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SMILES
CCN1N=C(C2CC2)C=C1NC3=NC(C(NCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=NC7=C3C8=CC(OC)=C(C(C(C)=NO9)=C9C)C=C8N7
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Structure
PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network. [Abstract]2024 Dec 5;32(12):2352-2363.e8. PMID: 39389062
Solvant et solubilité
DMSO : 100 mg/mL (95.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9567 mL | 4.7837 mL | 9.5674 mL | 23.9184 mL |
| 5 mM | 0.1913 mL | 0.9567 mL | 1.9135 mL | 4.7837 mL | |
| 10 mM | 0.0957 mL | 0.4784 mL | 0.9567 mL | 2.3918 mL | |
| 15 mM | 0.0638 mL | 0.3189 mL | 0.6378 mL | 1.5946 mL | |
| 20 mM | 0.0478 mL | 0.2392 mL | 0.4784 mL | 1.1959 mL | |
| 25 mM | 0.0383 mL | 0.1913 mL | 0.3827 mL | 0.9567 mL | |
| 30 mM | 0.0319 mL | 0.1595 mL | 0.3189 mL | 0.7973 mL | |
| 40 mM | 0.0239 mL | 0.1196 mL | 0.2392 mL | 0.5980 mL | |
| 50 mM | 0.0191 mL | 0.0957 mL | 0.1913 mL | 0.4784 mL | |
| 60 mM | 0.0159 mL | 0.0797 mL | 0.1595 mL | 0.3986 mL | |
| 80 mM | 0.0120 mL | 0.0598 mL | 0.1196 mL | 0.2990 mL |
PROTAC BET degrader-3 Related Classifications
HY-114229 Related Classifications
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