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Cat. No.: HY-182087

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ALK degrader 3

ALK degrader 3 is a ALK HyT degrader with an IC₅₀ of 1.2 nM. ALK degrader 3 inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes ALK to form a partially unfolded conformation, and drives ALK degradation via the proteasomal pathway. ALK degrader 3 inhibits the proliferation of tumor cells. ALK degrader 3 can be used for the research of non-small cell lung cancer. (ALK ligand: Brigatinib (HY-12857); hydrophobic tag: Tetraasterane (HY-W1139353)).

For research use only. We do not sell to patients.

Formula: C₄₇H₅₇ClN₇O₉P
Molecular Weight:930.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ALK degrader 3 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

ALK degrader 3 (compound B10) potently inhibits the proliferation of H3122 cells after 7 days, with an IC₅₀ of 97.77 nM^[1].
ALK degrader 3 (0.05-2 μM; 24 h) induces concentration-dependent degradation of ALK protein in H3122 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

H3122 cells
Concentration:

0.05, 0.1, 0.5, 1, 2 μM
Incubation Time:

24 h
Result:

Reduced ALK levels in a concentration-dependent manner.

Chemical Information

Molecular Weight 930.42
Formula C₄₇H₅₇ClN₇O₉P
SMILES

CP(C)(C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCC(N5CCN(C(C67C(CC8C9C7)(C(OC)=O)C%10C6CC9(C(OC)=O)C8(C(OC)=O)C%10)=O)CC5)CC4)C=C3OC)=NC=C2Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chu D, et al. Polyhedral alkanes as hydrophobic tags for dual-functional ALK inhibitor-degrader. Bioorg Chem. 2026;173:109674. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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