PROTAC SMARCA2/4 degrader-3
PROTAC SMARCA2/4 degrader-3 is a SMARCA2 and SMARCA4 PROTAC degrader. It is applicable to cancer-related research.
(Pink: SMARCA2 and SMARCA4 ligand (HY-159472); Blue: VHL ligand (HY-125845); Black: linker (HY-159478)).
For research use only. We do not sell to patients.
- CAS No.: 2568507-10-6
- Formula: C56H66N10O5S
- Molecular Weight:991.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SMARCA2 |
SMARCA4 |
PROTAC SMARCA2/4 degrader-3 (I-433) (24 h) potently degrades SMARCA2 in A549 cells with a DC50 < 100 nM and > 90% maximum degradation after 24 hours[1].
PROTAC SMARCA2/4 degrader-3 (24 h) potently degrades SMARCA2 in MV4-11 cells with a DC50 < 100 nM and >90% maximum degradation, and degrades SMARCA4 in MV4-11 cells with a DC50 < 100 nM and 50-70% maximum degradation after 24 hours[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2568507-10-6
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Molecular Weight 991.25
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Formula C56H66N10O5S
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SMILES
O=C([C@H]1N(C[C@H](O)C1)C([C@@H](NC(C2CC3(CC(C4=CC=C(CN5CCC(CC5)CN6N=CC(C7=C(N)N=NC(C8=C(O)C=CC=C8)=C7)=C6)C=C4)C3)C2)=O)C(C)(C)C)=O)NCC9=CC=C(C%10=C(C)N=CS%10)C=C9
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SMARCA2/4 degrader-3 Related Classifications
HY-159454 Related Classifications
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