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Art. -Nr.: HY-159454

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PROTAC SMARCA2/4 degrader-3

PROTAC SMARCA2/4 degrader-3 is a SMARCA2 and SMARCA4 PROTAC degrader. It is applicable to cancer-related research.
(Pink: ligand (HY-159472); Blue: ligand (HY-125845); Black: linker (HY-159478)).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2568507-10-6
Formel: C₅₆H₆₆N₁₀O₅S
Molecular Weight:991.25

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PROTAC SMARCA2/4 degrader-3 Chemical Structure

CAS. Nr.: 2568507-10-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PROTAC SMARCA2/4 degrader-3 is a SMARCA2 and SMARCA4 PROTAC degrader. It is applicable to cancer-related research^[1]. (Pink: ligand (HY-159472); Blue: ligand (HY-125845); Black: linker (HY-159478)).

IC₅₀ & Target

^[1]

SMARCA2

SMARCA4

Alle PROTACs Isoform-spezifische Produkte anzeigen :

Alle SWI/SNF Complex Isoform-spezifische Produkte anzeigen :

In Vitro

PROTAC SMARCA2/4 degrader-3 (I-433) (24 h) potently degrades SMARCA2 in A549 cells with a DC₅₀ < 100 nM and > 90% maximum degradation after 24 hours^[1].
PROTAC SMARCA2/4 degrader-3 (24 h) potently degrades SMARCA2 in MV4-11 cells with a DC₅₀ < 100 nM and >90% maximum degradation, and degrades SMARCA4 in MV4-11 cells with a DC₅₀ < 100 nM and 50-70% maximum degradation after 24 hours^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2568507-10-6
Molecular Weight 991.25
Formel C₅₆H₆₆N₁₀O₅S
SMILES

O=C([C@H]1N(C[C@H](O)C1)C([C@@H](NC(C2CC3(CC(C4=CC=C(CN5CCC(CC5)CN6N=CC(C7=C(N)N=NC(C8=C(O)C=CC=C8)=C7)=C6)C=C4)C3)C2)=O)C(C)(C)C)=O)NCC9=CC=C(C%10=C(C)N=CS%10)C=C9
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ji N, et al. Smarca degraders and uses thereof. US20230072658A1. USPTO. 2023.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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