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Cat. No.: HY-182018

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ATR ligand 2-CO-Ph-COOH

ATR ligand 2-CO-Ph-COOH (Compound 39) is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for ATR (HY-182017) and a PROTAC linker, which recruits E3 ligases. can be used for synthesis of PROTAC ATR degrader-3 (HY-182016).

For research use only. We do not sell to patients.

CAS No.: 3126270-19-4
Formula: C₂₇H₂₅N₅O₄
Molecular Weight:483.52

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Please store the product under the recommended conditions in the Certificate of Analysis.

ATR ligand 2-CO-Ph-COOH Chemical Structure

CAS No.: 3126270-19-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All ATM/ATR Isoforms :

Chemical Information

CAS No. 3126270-19-4
Molecular Weight 483.52
Formula C₂₇H₂₅N₅O₄
SMILES

C[C@@H]1COCCN1C2=C3C(CN(C3)C(C4=CC=C(C=C4)C(O)=O)=O)=NC(C5=CC=CC6=C5C=CN6)=N2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mao N D, et al. Design and Synthesis of Pyrrolo [3, 4-d] pyrimidine-Based ATR Degraders for Effective Treatment of Colorectal Cancer in Mouse Model[J]. Journal of Medicinal Chemistry, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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ATR ligand 2-CO-Ph-COOH

All ATM/ATR Isoforms