PROTAC BCL6 Degrader-3

Cat. No.: HY-186067 Purity: 99.76%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

PROTAC BCL6 Degrader-3 (compound 92) is a BCL6 PROTAC degrader. PROTAC BCL6 Degrader-3 can be used for the study of cancer or an autoimmune disease.
(Pink: BCL6 ligand (HY-186068); Blue: Cereblon ligand (HY-W593794); Black: linker (HY-W267161)).

For research use only. We do not sell to patients.

PROTAC BCL6 Degrader-3 Chemical Structure

CAS No. : 3005272-58-9

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Biological Activity
Purity & Documentation
References
Customer Review

Description

PROTAC BCL6 Degrader-3 (compound 92) is a BCL6 PROTAC degrader. PROTAC BCL6 Degrader-3 can be used for the study of cancer or an autoimmune disease^[1]. (Pink: BCL6 ligand (HY-186068); Blue: Cereblon ligand (HY-W593794); Black: linker (HY-W267161)).

Molecular Weight

646.11

Formula

C₃₂H₃₃ClFN₉O₃

CAS No.

3005272-58-9

Appearance

Solid

Color

White to off-white

SMILES

CN1C2=CC(N[C@H]3[C@@H](CN(C4=NC=C(Cl)C(NC5=C(F)C=C(N(C(C6)=O)C)C6=C5)=N4)CC3)C)=CC=C2C(C7C(NC(CC7)=O)=O)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (154.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5477 mL	7.7386 mL	15.4772 mL
5 mM	0.3095 mL	1.5477 mL	3.0954 mL
10 mM	0.1548 mL	0.7739 mL	1.5477 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.76%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (249 KB)

Handling Instructions (2659 KB)

References

[1]. Deborah S. Mortensen, et al. Modulators of bcl6 for use in a method of treating a cancer or an autoimmune disease. WO2025059429A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5477 mL	7.7386 mL	15.4772 mL	38.6931 mL
	5 mM	0.3095 mL	1.5477 mL	3.0954 mL	7.7386 mL
	10 mM	0.1548 mL	0.7739 mL	1.5477 mL	3.8693 mL
	15 mM	0.1032 mL	0.5159 mL	1.0318 mL	2.5795 mL
	20 mM	0.0774 mL	0.3869 mL	0.7739 mL	1.9347 mL
	25 mM	0.0619 mL	0.3095 mL	0.6191 mL	1.5477 mL
	30 mM	0.0516 mL	0.2580 mL	0.5159 mL	1.2898 mL
	40 mM	0.0387 mL	0.1935 mL	0.3869 mL	0.9673 mL
	50 mM	0.0310 mL	0.1548 mL	0.3095 mL	0.7739 mL
	60 mM	0.0258 mL	0.1290 mL	0.2580 mL	0.6449 mL
	80 mM	0.0193 mL	0.0967 mL	0.1935 mL	0.4837 mL
	100 mM	0.0155 mL	0.0774 mL	0.1548 mL	0.3869 mL